Cannabinoids in the Modulation of Oxidative Signaling

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2513 - 2513

Published: Jan. 28, 2023

Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), components of the endocannabinoids system, N-arachidonoylethanolamide (anandamide, AEA) 2-arachidonoylglycerol (2-AG), are extensively studied to investigate their numerous biological effects, including powerful antioxidant effects. Indeed, a series recent studies have indicated that many disorders characterized by alterations in intracellular which lead macromolecule damage. These pathological conditions an unbalanced, most often increased, reactive oxygen species (ROS) production. For this study, it was interest recapitulate properties these natural for part CBD THC, on production ROS modulation redox state, with emphasis use various reduction can be clinically useful, neurodegenerative disorders, inflammatory conditions, autoimmunity, cancers. The further development ROS-based fundamental research focused cannabis compounds could beneficial future clinical applications.

Language: Английский

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Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 8007 - 8032

Published: Jan. 1, 2024

Inflammatory skin diseases, such as psoriasis and atopic dermatitis, pose significant health challenges due to their long-lasting nature, potential for serious complications, risks, which requires treatments that are both effective exhibit minimal side effects. Hydrogels offer an innovative solution biocompatibility, tunability, controlled drug delivery capabilities, enhanced treatment adherence minimized effects risk. This review explores the mechanisms guide design of hydrogel therapeutic platforms from multiple perspectives, focusing on components hydrogels, adjustable physical chemical properties, interactions with cells drugs underscore clinical potential. We also examine various agents dermatitis can be integrated into including traditional drugs, novel compounds targeting oxidative stress, small molecule biologics, emerging therapies, offering insights advantages. Additionally, we trial data evaluate effectiveness safety hydrogel-based in managing under complex disease conditions. Lastly, discuss current future opportunities therapeutics treating improving barrier penetration developing multifunctional highlight enhance long-term stability.

Language: Английский

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Alleviative effects of combined topical melatonin and rutin on imiquimod-induced psoriasis mouse model

Pharmacia, Journal Year: 2024, Volume and Issue: 71, P. 1 - 13

Published: Sept. 3, 2024

Background : Psoriasis is a longstanding autoimmune dermatosis with thickened, reddish-brown, and flaking skin lesions. Melatonin an indolamine hormone exhibiting antioxidant, anti-inflammatory, anti-proliferative actions. Rutin nutritional flavonoid possessing antioxidative, immunomodulatory properties. Aim To explore the potential anti-psoriatic activity of combined topical melatonin rutin. Methods 70 albino mice were divided into 7 groups 10 each. The impacts clinical observation, histopathological examination, biomarker analysis estimated. Results Combined rutin effectively diminished imiquimod-induced elevated PASI Baker’s scores corrected aberrations. Diminished inflammatory indicators like TNF-α IL-17A, angiogenic elements VEGF, oxidative MDA, proliferative Ki-67 also noted. Conclusion have profound effects.

Language: Английский

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A bibliometrics study on the status quo and hot topics of pathogenesis of psoriasis based on Web of Science

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Jan. 1, 2024

Abstract Background Psoriasis is an immune‐mediated chronic inflammatory skin disease. Great progress has been made in the pathogenesis of psoriasis recent years, but there no bibliometric study on psoriasis. The purpose this was to use bibliometrics method analyze research overview and hot spots 10 so as further understand development trend frontier field. Methods core literatures were searched Web Science database, analyzed by VOSviewer, CiteSpace, Bibliometrix terms annual publication volume, country, institution, author, journal, keywords, on. Results A total 3570 included. China United States main countries field, Rockefeller University institution. Krueger JG, had highest number publications greatest influence, Boehncke (2015) most cited local literature. J INVEST DERMATOL takes top spot Dermatol articles citation frequency. hotspots are follows: (1) interaction between innate adaptive immunity related loop dominated Th17 cells IL‐23/IL‐17 axis still key mechanisms psoriasis; (2) molecular genetic studies represented Long Non‐Coding RNA (LncRNA); (3) integrated multi‐omics techniques gut microbiota; (4) Exploring comorbidity mechanism Metabolic Syndrome (MetS). Conclusion This a summary current status psoriasis, which will provide some reference for scholars studying

Language: Английский

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Etiopathogenesis of Psoriasis: Integration of Proposed Theories

Immunological Investigations, Journal Year: 2024, Volume and Issue: 53(3), P. 348 - 415

Published: Jan. 19, 2024

Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin involvement of immune system. Global prevalence for psoriasis has been reported around 1–3% with higher incidence in adults similar proportions between men women. The risk factors associated are both extrinsic intrinsic, out which polygenic predisposition highlight latter. etiology not yet fully described, but several hypothesis have proposed: 1) autoimmunity based over-expression antimicrobial peptides such as LL-37, proteins ADAMTSL5, K17, hsp27, or lipids synthesized PLA2G4D enzyme, all may serve autoantigens to promote differentiation autoreactive lymphocytes T unleash response; 2) dysbiosis microbiota gained relevance due observations loss diversity participation pathogenic bacteria Streptococcus spp. Staphylococcus fungi Malassezia Candida virus HPV, HCV, HIV psoriatic plaques; 3) oxidative stress hypothesis, most recent one, describes that cell injury release proinflammatory mediators leads activate Th1/Th17 axis observed caused reactive oxygen species imbalance oxidant antioxidant mechanisms. This review aims describe mechanisms involved three hypotheses etiopathogeneses psoriasis.

Language: Английский

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Twin defect-rich Pt ultrathin nanowire nanozymes alleviate inflammatory skin diseases by scavenging reactive oxygen species

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103055 - 103055

Published: Jan. 23, 2024

Nanozymes with superior antioxidant properties offer new hope for treating oxidative stress-related inflammatory skin diseases. However, lacking sufficient catalytic activity or having complex material designs limit the application of current metallic nanozymes in Here, we report a simple and effective twin-defect platinum nanowires (Pt NWs) enzyme multiple mimetic enzymes broad-spectrum ROS scavenging capability treatment diseases mice (including psoriasis rosacea). Pt NWs simultaneous superoxide dismutase, glutathione peroxidase catalase exhibit cytoprotective effects against ROS-mediated damage at extremely low doses significantly improve outcomes psoriasis- rosacea-like mice. Meanwhile, these ultrasmall sizes allow nanomaterials to effectively penetrate do not produce significant biotoxicity. Therefore, have potential applications related stress inflammation.

Language: Английский

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Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Oxidative stress and free radicals in disease pathogenesis: a review

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 14, 2025

Language: Английский

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Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

Biomolecules, Journal Year: 2022, Volume and Issue: 12(12), P. 1904 - 1904

Published: Dec. 19, 2022

Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays pivotal role pathogenesis and persistence lesions. Phototherapy represents one most used therapeutic options, with benefits clinical picture. Studies have demonstrated immunomodulatory effect phototherapy its reducing molecule hallmarks oxidative stress. In this review, we report data present literature dealing main signaling molecular pathways involved stress after to target atopic dermatitis-affected cells. Since flare-up, new research lines could be opened study drugs that act on mechanism, perhaps concert phototherapy.

Language: Английский

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Kaempferol modulates IFN-γ induced JAK-STAT signaling pathway and ameliorates imiquimod-induced psoriasis-like skin lesions

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 114, P. 109585 - 109585

Published: Dec. 15, 2022

Language: Английский

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