Small Ruminant Research, Journal Year: 2023, Volume and Issue: 226, P. 107036 - 107036
Published: July 6, 2023
Language: Английский
Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1141 - 1141
Published: May 23, 2023
As the world’s population grows, so does need for more and animal feed. In 2006, EU banned use of antibiotics other chemicals in order to reduce chemical residues food consumed by humans. It is well known that oxidative stress inflammatory processes must be combated achieve higher productivity. The adverse effects pharmaceuticals synthetic compounds on health product quality safety have increased interest phytocompounds. With plant polyphenols nutrition, they are gaining attention as a supplement Livestock feeding based sustainable, environmentally friendly approach (clean, safe, green agriculture) would also win–win farmers society. There an increasing producing healthier products origin with ratio polyunsaturated fatty acids (PUFAs) saturated modulating nutrition. Secondary metabolites (polyphenols) essential physiology involved various functions such growth, pigmentation, resistance pathogenic organisms. Polyphenols exogenous antioxidants act one first lines cell defense. Therefore, discoveries intracellular antioxidant activity contributed significantly improvement activity, prevent damage eliminate excessively produced free radicals. To welfare, medicines, increase origin, addition research breeding can practised part free-choice
Language: Английский
Citations
100
Advances in Redox Research, Journal Year: 2024, Volume and Issue: 11, P. 100099 - 100099
Published: April 9, 2024
Cellular metabolic activities are controlled by pathways catalyzed enzymes, closely regulated signal transduction through induction or inhibition processes. Metabolic disorders and cellular dysregulation often linked to redox-dependent signaling in a complex relationship. Glutathione (GSH) polyphenols which known regulators of redox homeostasis have been studied immensely. However, no study has considered their potential interactions synergies as novel mechanisms control disorders. GSH does not only act an antioxidant, but ligand that binds inactivate enzymes toxins. Also, depending on environment, structure, pH, concentration availability transition metals high charge density, may possess either anti-oxidant pro-oxidant properties. Owing remarkable influence individual compounds, this the between disease management. Generally, both reduce oxidative stress normal cells under exacerbating conditions low GSH/GSSG ratio, induce apoptotic abnormal cells. Investigating effects polyphenol concentrations, metals, caloric restriction structure apoptosis proliferation cancer future be basis for synergistic exploitation
Language: Английский
Citations
21
Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2888 - 2888
Published: Oct. 25, 2023
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Unhealthy dietary habits have clearly been shown to contribute development CVDs. Beyond primary nutrients, a healthy diet is also rich in plant-derived compounds. Natural polyphenols, found fruits, vegetables, red wine, clear role improving cardiovascular health. In this review, we strive summarize results relevant pre-clinical clinical trials that focused on some most important natural such as resveratrol flavonoids. addition, aim identify their common sources, biosynthesis, describe mechanism action including regulatory effect signal transduction pathways. Finally, provide scientific evidence regarding benefits moderate, long-term wine consumption.
Language: Английский
Citations
20
Animals, Journal Year: 2024, Volume and Issue: 14(3), P. 415 - 415
Published: Jan. 27, 2024
The aim of the study was to examine differences in chemical composition, polyphenol compounds, antioxidant activity, and vitro rumen fermentation among six varieties sorghum stalks. results show that maoliangnuo 1 (M1) contained a higher (p < 0.05) level dry matter, jinzhong 405 (J4) crude protein content. concentrations neutral detergent fiber, acid cellulose were significantly stalk jinliangnuo (JN). levels chlorogenic acid, homoorientin, isovitexin, vitexin, rhoifolin, genistin, quercetin, apigenin, aloe emodin, total polyphenols all maohongnuo 6 (M6) than other Moreover, M6 capacity (TAC), glutathione peroxidase (GPX), catalase (CAT), 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging capacity. There significant positive correlations between TAC, superoxide dismutase, GPX, CAT, DPPH gas production influenced by variety incubation time. Stalk J4 displayed values for immediately soluble fraction potential extent production, while exhibited lower insoluble level. Furthermore, ruminal fluid propionic but its butyric ratio acetic both 0.05). Taken together, reported this paper indicate vary greatly different
Language: Английский
Citations
7
Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4131 - 4131
Published: Dec. 20, 2024
Though ubiquitous in nature, polyphenols gained scientific prominence only after the pioneering work of researchers like E. Fischer and K. Freudenberg, who demonstrated their potential beyond traditional applications, such as leather industry. Today, these bioactive compounds are recognized for diverse therapeutic roles, including use adjuvants cancer treatment, prevention, anti-inflammatory antioxidant properties. Additionally, have benefits managing obesity, cardiovascular diseases, neuromodulation. Their synthesis is influenced by environmental genetic factors, with concentrations varying based on intensity variables, well stage ripening. This review provides a comprehensive overview polyphenols, covering classification, chemical structures, bioavailability. The mechanisms influencing bioavailability, bioaccessibility, bioactivity explored detail, alongside an introduction to effects associated metabolic pathways. Specific examples, bioavailability coffee various types onions, analyzed. Despite promising biological activities, significant limitation lies inherently low oral However, systemic circulation by-products formed during digestion present exciting opportunities further research application.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2328 - 2328
Published: March 5, 2025
Feed additives are crucial in livestock production, enhancing performance, health, and reproductive efficiency. Recently, there has been a shift toward natural biomolecules as feed additives, specifically targeting improved outcomes sperm quality. This transition arises from concerns about antibiotic misuse, antimicrobial resistance, consumer preferences for eco-friendly products, along with the superior bioavailability, lower toxicity, reduced environmental impact of compared to synthetic alternatives. Collaboration among researchers, veterinarians, nutritionists, regulators is essential ensure safe effective management. The review explores advancements using vital processes, including plant-derived bioactives such phytochemicals antioxidants. It investigates not only mechanisms but also intricate interactions these compounds animals' hormonal physiological systems. Additionally, critically assesses challenges prospects related incorporating into practices. potential benefits include enhanced efficiency However, successful implementation requires understanding factors like precise dosing, interactions, long-term health impacts. Overall, this comprehensive highlights recent research, technological strides, future integrating animal diets.
Language: Английский
Citations
0
Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12
Published: March 12, 2025
Bioactive plants provide therapeutic and prophylactic effects to ruminants. We determined the effect of grazing on natural meadow grassland enriched with experimentally sown chicory ( Cichorium intybus ) parasitological status, pasture larval infectivity, antioxidant parameters, histology abomasal tissue in lambs infected parasitic gastrointestinal nematode (GIN) Haemonchus contortus. also qualitatively identified main polyphenols phenolic metabolites feces lambs. Sixteen were orally approximately 5,000 infective larvae (L3) H. contortus . The divided into two groups: a plot consisting exclusively which serves as control group where 25% was reclaimed chicory. experimental period 144 days. number eggs per gram (EPG) quantified D21, D34, D48, D62, D76, D89, D103, D118, D131, D144 post-infection. Pasture contamination L3 examined. EPG both groups highest at D34. Egg shedding significantly lower from D48 onwards, reduction >95% D103 onwards. D41 but then groups. total capacity, activity glutathione peroxidase concentration malondialdehyde serum changed during experiment p < 0.003, 0.001, 0.016, respectively). At least 54 species plots; plant bioactive compounds mainly acids, flavonoids, glucosides. Phenolic (e.g., coumaric acid, salvigenin, esters gallic acid) In some lambs, morphological observation small histopathological changes tissues typical hemonchosis. Both slowed dynamics GIN infection by mobilizing defensive system gradually increasing resistance probably due beneficial substances.
Language: Английский
Citations
0
Animals, Journal Year: 2025, Volume and Issue: 15(7), P. 930 - 930
Published: March 24, 2025
Grape pomace, a winemaking byproduct, is nutrient- and polyphenol-rich, but research on its use in beef cattle limited. This study explored the impact of grape pomace-based complete pellet feed growth, serum biochemistry, fatty acid profile, rumen microbiota cattle. Fifteen healthy Simmental were randomly divided into three groups (G0, G15, G20) fed pelleted ration containing 0%, 15%, 20% respectively, for 60 days. The results showed that addition pomace to markedly increased average daily intake weight gain In terms levels total protein (TP) albumin (ALB) G20 group higher than G0 (p > 0.05). oleic acid, linoleic behenic group. had no significant effect fungal diversity volatile acids (TVFAs) pH ammonia nitrogen content G15 significantly indicates can be used as raw material
Language: Английский
Citations
0
Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(3)
Published: March 29, 2025
ABSTRACT The increasing demand for sustainable agricultural practices prompts a reevaluation of feeding strategies in ruminant nutrition. Agricultural waste, often viewed as by‐product (BP), presents promising opportunity to enhance the sustainability livestock production systems. This review explores potential incorporating various BPs into diets. Utilizing these reduces environmental impact farming and contributes circular economy by recycling nutrients back food system. nutritional composition wastes varies widely, their inclusion diets improves feed efficiency, animal performance overall health. Research indicates that specific treatments, such fermentation ensiling, digestibility nutrient availability materials. Moreover, waste nutrition leads financial benefits farmers reducing reliance on conventional sources. However, key challenges remain, particularly need further research optimize rates address anti‐nutritional factors found some wastes. Notably, adding materials results 10%–30% reductions costs improvements 5%–20% metrics, weight gain milk production. These findings highlight economic utilizing practices. emphasizes necessity developing innovative leverage calling interdisciplinary approaches combine nutrition, agronomy science. By adopting practices, sector security while minimizing its ecological footprint. Future focuses processing techniques, effective management factors, assessing long‐term impacts health productivity. Additionally, examining aspects commonly used BPs, pomegranate, grape, pistachio, saffron, raisin, olive tomato, is essential fully understanding guiding development targeted strategies.
Language: Английский
Citations
0
Molecules, Journal Year: 2023, Volume and Issue: 28(21), P. 7436 - 7436
Published: Nov. 5, 2023
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. considered phytoestrogen. As such, genistein can bind estrogen receptors (ERα ERβ), although with lower affinity than that of estradiol. Despite considerable work, the effects are not well established yet. This review aims clarify role on female male reproductive functions in mammals. In females, at high dose, diminishes ovarian activity regulating several pathway molecules, such as topoisomerase isoform I II, protein tyrosine kinases (v-src, Mek-4, ABL, PKC, Syk, EGFR, FGFR), ABC, CFTR, Glut1, Glut4, 5α-reductase, PPAR-γ, mitogen-activated kinase A, histidine kinase, recently circulating RNA-miRNA. The effect pregnancy still controversial. males, exerts an estrogenic by inducing testosterone biosynthesis. interaction both synthetic endocrine disruptors has negative testis function. positive sperm quality debate. conclusion, potentially beneficial mechanisms reproduction females males. However, this dependent species, route, time administration.
Language: Английский
Citations
9