Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 18, 2024

Impaired spermatogenesis and male infertility are common consequences of chemotherapy drugs used in patients with testicular cancer. The present study investigated the effects sodium alginate (NaAL) on toxicity caused by bleomycin, etoposide, cisplatin (BEP). Rats group 1 received normal saline, while groups 2 3 were treated 25 50 mg/kg NaAL, respectively. Group 4 was a 21-day cycle BEP (0.5 5 cisplatin), 6 regimen plus Then, sperm parameters, testosterone levels, histopathology stereological levels malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC), expression apoptosis-associated genes including Bcl2, Bax, Caspase3, p53, TNF-α evaluated. Our findings revealed that NaAL improved histopathology, stereology parameters BEP-administrated rats. also testis status enhancing TAC ameliorating MDA NO. Further, modifications to suggested alleviated BEP-induced apoptosis inflammation. Collectively, protects rats' testes against BEP-evoked damage through modulation nitro-oxidative stress, apoptosis,

Language: Английский

---

Effect of olive, flaxseed, and grape seed nano-emulsion essential oils on semen buffalo freezability

Theriogenology, Journal Year: 2023, Volume and Issue: 212, P. 9 - 18

Published: Aug. 30, 2023

Language: Английский

---

Effect of an extender enriched with algerian date palm pollen on chilled semen characteristics of rabbit bucks at different ages

World Rabbit Science, Journal Year: 2023, Volume and Issue: 31(2), P. 133 - 145

Published: June 30, 2023

In the present study, we evaluated effect of various concentrations date palm pollen (DPP) aqueous extract on rabbit sperm during storage at 4°C for 48 h. Semen was collected from old and young bucks using an artificial vagina initially quality. The were diluted in Tris buffer supplemented with (20, 40, 80 mg/mL) DPP extract. extended samples stored Sperm motility motion kinetics assessed after 2, 4, 24 h storage. At each time, aliquot frozen analytical evaluation thiobarbituric acid reactive substances (TBARS) (lipid peroxidation) tocols (vitamin E). Proximate composition, antioxidant sugar content DPP. results showed that characterised by a high proportion protein (27.10%) ash (18.43%), whereas lipid fraction very low (0.51%) total also (16.25 g/100 g fresh matter, f.m.). Regarding antioxidants content, sum value 26.48 mg/g f.m. polyphenols 5.01 mg gallic equivalents/g f.m, polyunsaturated fatty acids around 30%. Date had dose-dependent parameters (curvilinear velocity [VCL] mainly) rabbit, although null or negative recorded doses >DPP40. Conversely, optimal conditions (i.e. semen), addition no traits (motility VCL). progressive increase DPP, despite providing additional amount tocols, caused higher tocol consumption oxidation. particular, DPP80 increased TBARS level both ages. better trend found DPP20, where figures 10.46 % 15.28 %, respectively, bucks, oxidation lower compared to conclusion, findings this study demonstrated supplementation extender enhanced chilled semen only if administered concentration than 40 mg/mL.

Language: Английский

---

Diagnostic value of oxidation-reduction potential for male infertility: a systematic review and meta-analysis

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(7), P. 1228 - 1238

Published: July 1, 2024

Background: In the last few years, studies have initially confirmed diagnostic significance of oxidation-reduction potential (ORP) in male infertility patients. this article, we used meta-analysis to clarify role ORP diagnosis infertility. Methods: PubMed, Embase, Web Science, and Cochrane Library were searched by computer for relevant published literature. Quality assessment included literature was performed Assessment Diagnostic Accuracy Studies (QUADAS) scale. Heterogeneity analysis conducted using Metadisc 1.4 Stata 12.0, effective models quantitative synthesis selected based on heterogeneity results; sensitivity specificity obtained software, order reduce effects thresholds, information integrated. We subject receiver operating characteristic (SROC) curve, area under curve (AUC) Q* index comprehensive evaluation. Results: Seven papers eventually study, results showed that had a 0.81 [95% confidence interval (CI): 0.80–0.82] 0.66 (95% CI: 0.63–0.69), an AUC 0.8 0.74 Conclusions: has high diagnosing

Language: Английский

---

Case Report: Abnormalities of sperm motility and morphology in a patient with Leber hereditary optic neuropathy: Improvement after idebenone therapy

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 4, 2023

We report the sperm characteristics of a male patient who developed, when he was 18 years old, Leber hereditary optic neuropathy, neuropathy due to mtDNA mutation as well variants in nuclear DNA. At age 30 years-old, complained infertility lasting for 2 years. Semen analyses showed low motility spermatozoa and high percentage morphological or ultrastructural abnormalities. Levels epididymal markers were strongly atypical. Idebenone prescribed treatment his order improve visual acuity. After 5 months this treatment, increased, their vitality improved. A natural conception occurred.This case is first description an anomaly spermatozoas epididymis epithelium with neuropathy. It draws attention pathologies patients mitochondrial disorders. The role mutations must be suspected since it plays important development spermatozoa. In addition, idebenone can by-pass complex I transfer electrons III. has been have favorable effect on spermatogenesis.This confirms possibility dysfunction interest human.

Language: Английский

---