The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3258 - 3258

Published: July 23, 2023

The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention treatment strategies for disorders. Several gut microbiota, especially Firmicutes Bacteroidetes, are demonstrated affect health through microbiota-gut-brain axis, the microbiota dysbiosis can be related disorders, such as anxiety, depression, other On hand, dietary components, including probiotics Lactobacillus Bifidobacterium), prebiotics fiber alpha-lactalbumin), synbiotics, postbiotics short-chain fatty acids), dairy products, spices Zanthoxylum bungeanum, curcumin, capsaicin), fruits, vegetables, medicinal herbs, so on, could exert protective effects against by enhancing beneficial while suppressing harmful ones. In this paper, disorder-associated summarized. addition, components on targeting discussed. This paper helpful develop some natural products into pharmaceuticals functional foods prevent treat

Language: Английский

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Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1462 - 1487

Published: Jan. 31, 2023

Abstract Curcumin is extracted from the rhizomes Curcuma longa L. It known for its anti‐inflammatory and anti‐oxidant activities. Despite safety potential use against various diseases, curcumin's utility restricted due to low oral bioavailability. Co‐administration of curcumin along with piperine could potentially improve bioavailability curcumin. The present review aimed provide an overview efficacy curcumin‐piperine co‐supplementation in human health. findings this comprehensive show beneficial effects improving glycemic indices, lipid profile antioxidant status diabetes, inflammatory caused by obesity metabolic syndrome, reducing oxidative stress depression chronic neurological disorders, also respiratory asthma COVID‐19. Further high‐quality clinical trial studies are needed firmly establish supplement.

Language: Английский

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Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8874 - 8874

Published: May 17, 2023

Curcumin is the principal curcuminoid found in rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely medicine since ancient times. low solubility, human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation microemulsion nanoemulsion systems, are currently being improve bioavailability. This review discusses different methods available for curcumin from plant material, identification resulting extracts, beneficial effects on health, techniques into small colloidal systems that have over past decade deliver this compound.

Language: Английский

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Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3954 - 3972

Published: June 4, 2024

Driven by iron-dependent lipid peroxidation, ferroptosis is regulated p53 and solute carrier family 7 member 11 (SLC7A11)/glutathione/glutathione peroxidase 4 (GPX4) axis in colorectal cancer (CRC). This study aimed to investigate the influence of curcumin (CUR) on CRC. The efficacies CUR malignant phenotype CRC cells were determined 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, wound healing, clonogenic assays. effects evaluated transmission electron microscopy, lactate dehydrogenase release assay, Fe

Language: Английский

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Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(1)

Published: Jan. 1, 2024

Abstract Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness limited due to poor absorption rapid elimination the body. Various curcumin derivatives have also shown anticancer potential in‐vitro in‐vivo models. multiple signaling pathways development/progression or induce cell death through apoptosis. In addition, could enhance of conventional chemotherapy, radiation therapy reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored overcome challenges with curcumin's delivery, increasing overall efficacy. The use an imaging system track these formulations give beneficial information about bioavailability distribution nano‐curcumin complex. conclusion, holds significant promise fight against cancer, especially nanoform, provide precise cells without affecting normal healthy cells.

Language: Английский

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Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

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The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1680 - 1680

Published: Jan. 14, 2023

Various literature data show how a diet rich in vegetables could reduce the incidence of several cancers due to contribution natural polyphenols contained them. Polyphenols are attributed multiple pharmacological actions such as anti-inflammatory, anti-oxidant, antibiotic, antiseptic, anti-allergic, cardioprotective and even anti-tumor properties. The mechanisms involved their action include signaling pathways modulation associated with cell proliferation, differentiation, migration, angiogenesis, metastasis death. Since dysregulation death processes is cancer etiopathology, compounds able kill cells be used new anticancer agents. Apoptosis, programmed form death, most potent defense against main mechanism by both chemotherapy agents polyphenols. aim this review provide an update on apoptotic molecular induced some representative polyphenol family members cells. This aspect particularly important because it may useful design therapeutic strategies involving adjuvants.

Language: Английский

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Liposomes and phytosomes: Nanocarrier systems and their applications for the delivery of phytoconstituents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215251 - 215251

Published: May 29, 2023

Language: Английский

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The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 16, 2023

Abstract Resveratrol, curcumin, and quercetin are the secondary metabolites from medicinal food homology plants, that have been proven their potency in cancer treatment. However, antitumor effect of a single component is weak. So, herein, we designed an compound named RCQ composed resveratrol, quercetin. This study examined on tumorigenesis development 4T1 breast cancer-bearing mice following administering by intragastric administration. increased recruitment T cells reduced accumulation neutrophils macrophages tumor microenvironment. Meanwhile, suppressed tumor-infiltrating lymphocytes into immunosuppressive cell subpopulations, including CD4 + to helper Type 2 type (Th2), tumor-associated (TANs) N2 TANs, (TAMs) M2 TAMs. reversed predominance infiltrating microenvironment tipped immune balance toward activation state. In vitro showed significantly reactive oxygen species (ROS), reduce mitochondrial membrane potentials cells, modulate pro-apoptotic Bcl-2 family members. conclusion, can promote ROS apoptosis mechanism alleviate immunosuppression enhance anti-tumor effect.

Language: Английский

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Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 261 - 261

Published: Jan. 17, 2023

Plant-derived bioactive compounds are gaining wide attention for their multiple health-promoting activities and in particular anti-cancer properties. Several studies have highlighted how they can prevent cancer initiation progression, improve the effectiveness of chemotherapy, and, some cases, limit side effects chemotherapy agents. In this paper, we provide an update literature on three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, curcumin, with a special focus molecular mechanisms inducing apoptosis major types cancers globally.

Language: Английский

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