Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(5), P. 1919 - 1955
Published: Feb. 11, 2023
Chronic
heart
failure
(CHF)
is
a
severe
public
health
problem
with
increasing
morbidity
and
mortality,
any
treatment
targeting
single
session
insufficient
to
tackle
this.
CHF
characterized
by
reduced
cardiac
output
resulting
from
neurohumoral
dysregulation
remodeling,
which
might
be
related
oxidative
stress,
inflammation,
endoplasmic
reticulum
apoptosis,
autophagy,
mitochondrial
function,
angiogenesis.
These
molecular
mechanisms
interact
each
other
through
crosstalk.
Historically,
Chinese
medicinal
herbs
have
been
widely
applied
in
the
of
CHF,
therapeutic
effects
their
ingredients
scientifically
confirmed
over
past
decades.
Traditional
medicine
(TCM)
multiple
components
can
confront
different
pathogenesis
targets.
This
review
analyzes
commonly
used
TCM
patent
drugs
decoctions
that
are
applicable
stages
based
on
clinical
trials.
Diverse
bioactive
found
treat
via
mechanisms.
comprehensively
covers
key
works
underlying
TCM,
herbal
synergistic
constituent
compatibility
treating
providing
additional
ideas
address
this
threat.
Antioxidants and Redox Signaling,
Journal Year:
2024,
Volume and Issue:
40(7-9), P. 369 - 432
Published: Feb. 1, 2024
Physiological
levels
of
reactive
oxygen
and
nitrogen
species
(ROS/RNS)
function
as
fundamental
messengers
for
many
cellular
developmental
processes
in
the
cardiovascular
system.
ROS/RNS
involved
cardiac
redox-signaling
originate
from
diverse
sources,
their
are
tightly
controlled
by
key
endogenous
antioxidant
systems
that
counteract
accumulation.
However,
dysregulated
redox-stress
resulting
inefficient
removal
leads
to
inflammation,
mitochondrial
dysfunction,
cell
death,
contributing
development
progression
disease
(CVD).
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4321 - 4321
Published: Feb. 21, 2023
Heart
failure
is
a
complex
medical
syndrome
that
attributed
to
number
of
risk
factors;
nevertheless,
its
clinical
presentation
quite
similar
among
the
different
etiologies.
displays
rapidly
increasing
prevalence
due
aging
population
and
success
treatment
devices.
The
pathophysiology
heart
comprises
several
mechanisms,
such
as
activation
neurohormonal
systems,
oxidative
stress,
dysfunctional
calcium
handling,
impaired
energy
utilization,
mitochondrial
dysfunction,
inflammation,
which
are
also
implicated
in
development
endothelial
dysfunction.
with
reduced
ejection
fraction
usually
result
myocardial
loss,
progressively
ends
remodeling.
On
other
hand,
preserved
common
patients
comorbidities
diabetes
mellitus,
obesity,
hypertension,
trigger
creation
micro-environment
chronic,
ongoing
inflammation.
Interestingly,
dysfunction
both
peripheral
vessels
coronary
epicardial
microcirculation
characteristic
categories
has
been
associated
worse
cardiovascular
outcomes.
Indeed,
exercise
training
drug
display
favorable
effects
against
apart
from
their
established
direct
benefit.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 17, 2025
In
the
vascular
system,
angiotensin
II
(Ang
II)
mediated
vasoconstriction
by
inducing
production
of
20-hydroxyeicosatetraenoic
acid
(20-HETE).
However,
role
20-HETE
in
Ang
II-induced
cardiac
dysfunction
had
yet
to
be
fully
elucidated.
This
study
investigated
effects
on
CYP4A
expression
and
H9c2
cells
using
RT-qPCR,
Western
blot,
ELISA.
The
hypertrophy
was
examined
DHE,
MitoSOX,
JC-1
staining
evaluate
reactive
oxygen
species
(ROS)
generation
mitochondrial
membrane
potential
changes.
ERK/Akt
CaN/NFAT3
signaling
pathways
were
analyzed
through
blot.
found
promote
via
an
AT1
receptor-dependent
mechanism.
Additionally,
upregulation
receptor
further
confirms
its
facilitatory
effect
pathway.
Inhibition
synthesis
or
blockade
receptor,
G-protein-coupled
75
(GPR75),
significantly
reversed
hypertrophy.
reversal
closely
associated
with
20-HETE-induced
ROS
production,
oxidative
stress,
activation
Ca2+/CaN/NFAT3
demonstrated
that
and,
for
first
time,
highlighted
significant
GPR75
this
process.
These
findings
suggested
targeting
reduction
blocking
action
could
offer
a
novel
therapeutic
approach
cardiovascular
diseases
II.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(11), P. 4491 - 4491
Published: June 1, 2023
Insulin
resistance
(IR)
and
the
associated
hyperinsulinemia
are
early
pathophysiological
changes
which,
if
not
well
treated,
can
lead
to
type
2
diabetes,
endothelial
dysfunction
cardiovascular
disease.
While
diabetes
care
is
fairly
standardized,
prevention
treatment
of
IR
lacks
a
single
pharmaceutical
approach
many
lifestyle
dietary
interventions
have
been
proposed,
including
wide
range
food
supplements.
Among
most
interesting
well-known
natural
remedies,
alkaloid
berberine
flavonol
quercetin
particular
relevance
in
literature,
while
silymarin—the
active
principle
Silybum
marianum
thistle—was
traditionally
used
for
lipid
metabolism
disorders
sustain
liver
function.
This
review
describes
major
defects
insulin
signaling
leading
main
properties
three
mentioned
substances,
their
molecular
targets
synergistic
action
mechanisms.
The
actions
berberine,
silymarin
partially
superimposable
as
remedies
against
reactive
oxygen
intermediates
generated
by
high-lipid
diet
NADPH
oxidase,
which
triggered
phagocyte
activation.
Furthermore,
these
compounds
inhibit
secretion
battery
pro-inflammatory
cytokines,
modulate
intestinal
microbiota
especially
able
control
various
receptor
post-receptor
systems.
Although
evidence
on
effects
modulating
preventing
disease
derive
from
experimental
studies
animals,
amount
pre-clinical
knowledge
strongly
suggests
need
investigate
therapeutic
potential
substances
human
pathology.
Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
26(9), P. 3684 - 3695
Published: June 14, 2024
Abstract
Aim
To
analyse
the
association
between
serum
bile
acid
(BA)
profile
and
heart
failure
(HF)
with
preserved
ejection
fraction
(HFpEF)
in
patients
metabolic
dysfunction‐associated
fatty
liver
disease
(MAFLD).
Methods
We
enrolled
163
individuals
biopsy‐proven
MAFLD
undergoing
transthoracic
echocardiography
for
any
indication.
HFpEF
was
defined
as
left
ventricular
>50%
at
least
one
echocardiographic
feature
of
HF
(left
diastolic
dysfunction,
abnormal
atrial
size)
sign
or
symptom.
Serum
levels
38
BAs
were
analysed
using
ultra‐performance
liquid
chromatography
coupled
tandem
mass
spectrometry.
Results
Among
(mean
age
47.0
±
12.8
years,
39.3%
female),
52
(31.9%)
43
(26.4%)
met
pre‐HFpEF
criteria,
detected.
ursodeoxycholic
(UDCA)
hyocholic
(HCA)
species
lower
achieved
statistical
significance
after
correction
multiple
comparisons.
Furthermore,
decreases
glycoursodeoxycholic
tauroursodeoxycholic
associated
status.
Conclusions
In
this
exploratory
study,
specific
UDCA
HCA
status
adults
biopsy‐confirmed
MAFLD.
Biochemical Society Transactions,
Journal Year:
2024,
Volume and Issue:
52(1), P. 41 - 53
Published: Feb. 22, 2024
Despite
the
well-established
functions
of
protein
palmitoylation
in
fundamental
cellular
processes,
roles
this
reversible
post-translational
lipid
modification
cardiomyocyte
biology
remain
poorly
studied.
Palmitoylation
is
catalyzed
by
a
family
23
zinc
finger
and
Asp-His-His-Cys
domain-containing
S-acyltransferases
(zDHHC
enzymes)
removed
select
thioesterases
lysophospholipase
α/β-hydroxylase
domain
(ABHD)-containing
families
serine
hydrolases.
Recently,
studies
utilizing
genetic
manipulation
zDHHC
enzymes
cardiomyocytes
have
begun
to
unveil
essential
for
these
regulating
cardiac
development,
homeostasis,
pathogenesis.
co-ordinates
electrophysiology
through
direct
modulation
ion
channels
transporters
impact
their
trafficking
or
gating
properties
as
well
indirectly
regulators
channels,
transporters,
calcium
handling
machinery.
Not
surprisingly,
has
orchestrating
intracellular
proteins
cardiomyocytes,
but
also
dynamically
fine-tunes
exocytosis
natriuretic
peptide
secretion.
emerged
potent
regulator
signaling
with
recent
uncovering
palmitoylation-dependent
regulation
small
GTPases
sarcolemmal
targeting
themselves
GTPase
cycle.
In
addition
dynamic
control
G
signaling,
cytosolic
DNA
sensed
transduced
into
an
inflammatory
transcriptional
output
activation
cGAS-STING
pathway,
which
been
targeted
pharmacologically
preclinical
models
heart
disease.
Further
research
needed
fully
understand
complex
regulatory
mechanisms
governed
potential
emerging
therapeutic
targets.
