Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases DOI Creative Commons

Nikhil Raj Selvaraj,

Durga Nandan,

B J Bipin Nair

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

Insights Into the Therapeutic Potential of SIRT1-modifying Compounds for Alzheimer’s Disease: A Focus on Molecular Mechanisms DOI

Dhyauldeen Aftan Al-Hayani,

Aziz Kubaev,

Subasini Uthirapathy

et al.

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(1)

Published: Feb. 25, 2025

Language: Английский

Citations

0
The Peripheral Amyloid-β Nexus: Connecting Alzheimer’s Disease with Atherosclerosis through Shared Pathophysiological Mechanisms DOI Creative Commons
Manal M. Khowdiary, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 3, 2025

Abstract Alzheimer’s disease (AD) and atherosclerosis (AS) are two chronic diseases with seemingly distinct pathologies. However, emerging research points to a bidirectional relationship driven by common mechanisms, such as inflammation, oxidative stress, dysregulation of Amyloid-Beta (Aβ). This review focuses on the role Aβ critical molecular link between AD AS, emphasizing its contribution neuronal impairment vascular damage. Specifically, peripheral produced in pancreas skeletal muscle tissues exacerbates AS promoting endothelial dysfunction insulin resistance (IR). Furthermore, accelerates progression impairing cerebral blood flow inducing hypoxia, causing accumulation. critically evaluates recent findings, highlighting inconsistencies clinical studies suggesting future directions. Understanding influence could pave way for novel therapeutic approaches targeting shared pathways, particularly clearance inflammation.

Language: Английский

Citations

0
Molecular Mechanisms of Neuroprotection: The Interplay of Klotho, SIRT-1, Nrf2, and HO-1 in Neurological Health DOI

R.S. Rana,

R Mukherjee,

Sidharth Mehan

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115545 - 115545

Published: March 1, 2025

Language: Английский

Citations

0
GSK-3β dysregulation in aging: Implications for tau pathology and Alzheimer's disease progression DOI
Arcot Rekha, Muhammad Afzal, M. Arockia Babu

et al.

Molecular and Cellular Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 104005 - 104005

Published: March 1, 2025

Language: Английский

Citations

0
Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases DOI Creative Commons

Nikhil Raj Selvaraj,

Durga Nandan,

B J Bipin Nair

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

Citations

0