Lambertianic Acid from Platycladus orientalis Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells DOI Creative Commons

Chan Hee Cho,

Si Hyeon Chae,

Ngoc Han Le Thi

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(9), P. 1357 - 1357

Published: April 30, 2025

Platycladus orientalis, an evergreen tree belonging to the Cupressaceae family, has been traditionally used treat various ailments, including fever, cough, diarrhea, diuresis, cold symptoms, and gastrointestinal disorders in folk medicine. As part of our ongoing investigation aimed at discovering bioactive natural products elucidating their mechanisms action from sources, we investigated a methanol (MeOH) extract P. orientalis leaves. This led isolation identification labdane-type diterpene, lambertianic acid (LA), via column chromatography HPLC purification. The structure LA was elucidated using LC/MS NMR spectroscopic analyses, HR-ESIMS, while its absolute configuration confirmed through electronic circular dichroism (ECD) calculations. Recent studies have reported that diterpenes exhibit diverse pharmacological activities, such as anticancer, anti-inflammatory, anti-obesity, hypolipidemic effects. Notably, shown modulate adipocyte metabolism AMPK signaling; however, role skeletal muscle atrophy remains unexplored. Therefore, this study, effects on dexamethasone (Dex)-induced C2C12 myotubes. Treatment with concentrations 25 µM 50 significantly rescued myotube diameter reduced expression atrophy-related proteins, MuRF-1 atrogin-1/MAFbx, without compromising cell viability these moderate concentrations. These findings suggest derived exerts protective against atrophy, highlighting potential promising therapeutic candidate for muscle-wasting disorders.

Language: Английский

Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms DOI
Yuntian Shen, Chen Zhang,

Chaolun Dai

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(10)

Published: May 1, 2024

Abstract Skeletal muscle can undergo detrimental changes in various diseases, leading to dysfunction and atrophy, thus severely affecting people's lives. Along with exercise, there is a growing interest the potential of nutritional support against atrophy. This review provides brief overview molecular mechanisms driving skeletal atrophy summarizes recent advances interventions for preventing treating The supplements include amino acids their derivatives (such as leucine, β‐hydroxy, β‐methylbutyrate, creatine), antioxidant (like Coenzyme Q10 mitoquinone, resveratrol, curcumin, quercetin, Omega 3 fatty acids), minerals magnesium selenium), vitamins vitamin B, C, D, E), well probiotics prebiotics Lactobacillus, Bifidobacterium, 1‐kestose). Furthermore, study discusses impact combined approach involving physical therapy prevent suggests appropriate multi‐nutritional multi‐modal based on individual conditions optimize treatment outcomes, enhances recovery function patients. By understanding behind implementing interventions, it possible enhance improve patients' quality life.

Language: Английский

Citations

7
Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging DOI Creative Commons
Jae Gyu Kim, Ashish Ranjan Sharma, Yeon‐Hee Lee

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Quercetin (QC), a naturally occurring bioflavonoid found in various fruits and vegetables, possesses many potential health benefits, primarily attributed to its robust antioxidant properties. The generation of oxidative stress bone cells is key modulator their physiological behavior. Moreover, status influences the pathophysiology mineralized tissues. Increasing scientific evidence demonstrates that manipulating redox balance might be an effective technique for developing disease therapies. QC abilities skeletal muscle significantly enhance regeneration reduce atrophy. In addition, has been shown have protective effects against stress, inflammation, apoptosis, matrix degradation tendons, helping maintain structural integrity functionality tendons. Thus, properties crucial addressing age-related musculoskeletal disorders like osteoporosis, sarcopenia, tendon-related inflammatory conditions. Understanding how signaling pathways involved disorders, including effect on bone, muscle, tendon differentiation, provide insights into diverse advantages promoting tissue preventing cellular damage. Therefore, this study reviewed intricate relationship among repair, affected by antioxidative QC, tissues improve overall bones, muscles, tendons system. Also, reviewing ongoing clinical trials systems encouraging. Given positive health, further investigations controlled human intervention studies are necessary explore therapeutic optimum strength.

Language: Английский

Citations

7
Skeletal muscle as a pro- and anti-inflammatory tissue: insights from children to adults and ultrasound findings DOI Creative Commons
Armando Di Ludovico, Saverio La Bella,

Francesca Ciarelli

et al.

Journal of Ultrasound, Journal Year: 2024, Volume and Issue: 27(4), P. 769 - 779

Published: June 21, 2024

Abstract Previously regarded as a movement and posture control agent, the skeletal muscle is now recognized an endocrine organ that may affect systemic inflammation metabolic health. The discovery of myokines such IL-6, released from in response to physical exercise, one most recent insights. Myokines are mediators balance between pro-inflammatory anti-inflammatory responses. This underscores function determinant good health prevention diseases. Advances ultrasound technology improved evaluation thickness, composition, determining fat distribution. Combining imaging with molecular biology, researchers discovered complicated interplay function, cytokine production general effects.The exercise showcasing adaptability muscles high-stress conditions contributing metabolism regulation. These findings have significant implications order provide improvement inflammatory

Language: Английский

Citations

6
Impact of Chinese herbal medicine on sarcopenia in enhancing muscle mass, strength, and function: A systematic review and meta‐analysis of randomized controlled trials DOI Creative Commons
Yujie Zhang,

Kaoqiang Liu,

Yunfan Zhan

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2303 - 2322

Published: Feb. 29, 2024

Abstract Sarcopenia has become important to the public health with increase in aging population society. However, therapeutic effects of conventional approaches, including pharmacotherapy, exercise, and nutritional intervention, are far from satisfactory. Chinese herbal medicine is a new treatment format interesting possibilities sarcopenia been widely practiced. The study aims explore effectiveness sarcopenia. We comprehensively searched following electronic databases: Medline, EMBASE, APA PsycInfo, Cochrane Library, Web Science, PubMed, database establishment December 2022 (no language restrictions). Randomized controlled clinical studies on use were selected compliance PRISMA guidelines. Review Manager Stata used for statistical analysis mean difference standardized adopted. Of 277 identified studies, 17 eligible included our ( N = 1440 participants). results showed that can improve total efficiency (RR 1.29, 95% CI [1.21, 1.36], p < 0.00001) enhance muscle mass (SMD 1.02, [0.55, 1.50], 0.0001), strength measured by grip 0.66, [0.36, 0.96], 60°/s knee extension peak TQ (MD 5.63, [−0.30, 11.57], 0.06) function 6‐meter walking speed 1.34, [0.60, 2.08], 0.0004), short physical performance battery 1.50%, (1.05, 1.95), EuroQoL 5‐dimension 0.27, [−0.10, 0.65], 0.16), suggesting alone or combined ameliorating effect potential strategy funnel plot Egger's test indicated publication bias. To confirm conclusions, further high‐quality should be conducted.

Language: Английский

Citations

5
The effects of β-hydroxy-β-methylbutyrate or HMB-rich nutritional supplements on sarcopenia patients: a systematic review and meta-analysis DOI Creative Commons
Hai Su, Haojing Zhou, Yichen Gong

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 12, 2024

Background Sarcopenia is a progressive, systemic skeletal muscle disorder. Resistance exercise and physical activity have been proven effective in its treatment, but consensus on pharmacological interventions has not yet reached clinical practice. β-Hydroxy-β-methylbutyrate (HMB) nutritional supplement that demonstrated favorable effects protein turnover, potentially contributing to beneficial impacts sarcopenia. Aim To assess the potential positive of HMB or HMB-containing supplements individuals with sarcopenia, systematic review meta-analysis was conducted. Methods A were conducted randomized controlled trials (RCTs) examining treatment sarcopenia HMB. Two assessors independently screening, data extraction, bias risk assessment. Outcome synthesized through random-effects model meta-analysis, using mean difference (MD) as effect measure. Results six studies. HMB-rich showed statistically significant Hand Grip Strength (HGS) for patients [MD = 1.26, 95%CI (0.41, 2.21), p 0.004], while there no Gait Speed (GS) 0.04, (−0.01, 0.08), 0.09], Fat Mass (FM) −0.18, (−0.38, 0.01), 0.07], Fat-Free (FFM) 0.09, (−0.23, 0.42), 0.58], Skeletal Muscle Index (SMI) 0.01, (−0.00, 0.13]. Conclusion are strength patients. However, limited evidence demonstrating both performance individuals. may be considered option Systematic registration CRD42024512119.

Language: Английский

Citations

5
Does photobiomodulation alter mitochondrial dynamics? DOI Open Access
Larissa Alexsandra da Silva Neto Trajano, Priscyanne Barreto Siqueira, Mariana Moreno de Sousa Rodrigues

et al.

Photochemistry and Photobiology, Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Mitochondrial dysfunction is one of the leading causes disease development. Dysfunctional mitochondria limit energy production, increase reactive oxygen species generation, and trigger apoptotic signals. Photobiomodulation a noninvasive, nonthermal technique involving application monochromatic light with low density, inducing non-thermal photochemical effects at cellular level, it has been used due to its therapeutic potential. This review focuses on mitochondrial dynamic's role in various diseases, evaluating possible low-power lasers (LPL) light-emitting diodes (LED). Studies increasingly support that correlated severe neurodegenerative diseases such as Parkinson's, Huntington's, Alzheimer's, Charcot-Marie-Tooth diseases. Furthermore, disturbance mitofusin activity also associated metabolic disorders, including obesity type 2 diabetes. The PBM dynamics have observed cells using human fibroblast cell line vivo models brain injury, diabetes, spinal cord Alzheimer's disease, skin injury. Thus, new therapies aiming improve are clinically relevant. Several studies demonstrated LPL LED can be important health conditions when there dynamics.

Language: Английский

Citations

4
Muscle preservation in proximal nerve injuries: a current update DOI
A.S. Lysak, Simon Farnebo, Stefano Geuna

et al.

Journal of Hand Surgery (European Volume), Journal Year: 2024, Volume and Issue: 49(6), P. 773 - 782

Published: May 31, 2024

Optimal recovery of muscle function after proximal nerve injuries remains a complex and challenging problem. After injury, alterations in the affected muscles lead to atrophy, later degeneration replacement by fat-fibrous tissues. At present, several different strategies for preservation skeletal have been reported, including various sets physical exercises, massage, methods (e.g. electrical stimulation, magnetic field laser low-intensity pulsed ultrasound), medicines nutrients, natural chemical agents, anti-inflammatory antioxidants, hormones, enzymes enzyme inhibitors), regenerative medicine growth factors, stem cells microbiota) surgical procedures supercharge end-to-side neurotization). The present review will focus on that aimed minimize damage denervation based our knowledge.

Language: Английский

Citations

4
Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy DOI
Yingjie Wang, Zehao Chen, Yuntian Shen

et al.

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 24, 2025

Skeletal muscle atrophy results from disruptions in the growth and metabolism of striated muscle, leading to a reduction or loss fibers. This condition not only significantly impacts patients' quality life but also imposes substantial socioeconomic burdens. The complex molecular mechanisms driving skeletal contribute absence effective treatment options. Recent advances stem cell therapy have positioned it as promising approach for addressing this condition. article reviews outlines current therapeutic strategies, focusing on mesenchymal cells, induced pluripotent their derivatives. Additionally, challenges these cells face clinical applications are discussed. A deeper understanding regenerative potential various could pave way breakthroughs prevention atrophy.

Language: Английский

Citations

0
Effect of transcutaneous electrical acupoint stimulation on postoperative muscle atrophy in patients with foot and ankle fracture: A randomized controlled pilot study DOI Creative Commons
Ying Xue,

Xiaoqian Dai,

Xueming Chen

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Puerarin Ameliorates Sarcopenia in Aged Mice via Modulation of Inflammation and Oxidative Stress: Insights from Proteomics and Transcriptomics DOI Creative Commons

Shangjin Lin,

Ying Cheng, Tao Cui

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Sarcopenia, a chronic degenerative condition associated with aging, is characterized by significant decline in muscle mass and strength. Puerarin, major active isoflavone extracted from Pueraria lobata, exhibits potent anti-inflammatory antioxidant properties. However, its therapeutic effects on sarcopenia remain unclear. Thus, the purpose of this study was to evaluate underlying molecular mechanisms puerarin ameliorating naturally aged mice. Twenty-month-old male C57BL/6 J mice were randomly divided into two groups based body weight: group (puerarin dissolved double-distilled water, 150 mg/kg/day) control (equal volume water). After an 8-week intervention, changes function between compared. Techniques such as HE staining, immunofluorescence ELISA, transmission electron microscopy, Western blot, qRT-PCR employed positive Furthermore, serum proteomics transcriptomics used analyze anti-muscle atrophy puerarin. The results demonstrated that significantly improved composition, enhanced function, exerted modulating inflammatory cytokines, reducing oxidative stress, inhibiting expression apoptosis proteins skeletal muscle. Additionally, integrated analyses suggested might be related TNF-α/NF-κB signaling pathway. These findings highlight puerarin's potential agent for sarcopenia, providing foundation further research clinical application.

Language: Английский

Citations

0