96th National Congress of the Italian Society for Experimental Biology | L’Aquila, Italy, 25-28 April 2024

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, Journal Year: 2024, Volume and Issue: 97(s1)

Published: April 12, 2024

96th National Congress of the Italian Society for Experimental Biology | L’Aquila, Italy, 25-28 April 2024

Language: Английский

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Pancreatic and hepatic histopathology of high-fat diet fed streptozotocin-induced Wistar rat model of type 2 diabetes mellitus

Ceylon Journal of Science, Journal Year: 2024, Volume and Issue: 53(2), P. 235 - 242

Published: May 7, 2024

In search of new fangled therapeutic agents against type 2 diabetes mellitus (T2DM), an appropriate preclinical disease model is important to ensure the success subsequent clinical trials. There increasing trend in use high-fat diet (HFD) fed streptozotocin (STZ)-induced rodent models investigating novel T2DM. Though several studies have been conducted on development aforementioned they were mainly focused biochemical characteristics. Only limited histopathological changes which gold standard treatment-related agents. Therefore, present study aimed at assessing pancreas and liver, two main organs involved glucose homeostasis, a newly developed HFD-fed STZ-induced Wistar rat model. For this study, rats induced with T2DM by intraperitoneal injection STZ (30, 40, 50 mg/kg) was given after feeding HFD consisting 60% calories from fat for four weeks duration. Diabetic sacrificed maintaining further weeks. The liver excised hematoxylin eosin-stained sections observed using light microscope. major diabetic loss pancreatic islets, islet hypertrophy, mild fatty change exocrine pancreas. contrast, did not show any degree change, but majority showed prominent hydropic degeneration hepatocytes. conclusion, alterations well noted tissues HFD, followed (50 mg/kg), established could be useful elucidating antidiabetic mechanisms pharmaceutical

Language: Английский

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Metabolic syndrome and neuroprotection

SCT Proceedings in Interdisciplinary Insights and Innovations., Journal Year: 2024, Volume and Issue: 2, P. 341 - 341

Published: June 26, 2024

Introduction: cardiovascular diseases represent one of the main causes death and disability in women, turn, multicausal hypertensive disorders pregnancy include chronic hypertension, gestational preeclampsia/eclampsia, hypertension with overlapping preeclampsia/eclampsia. The objective was to describe importance intervention studies about pregnancy. Methods: a bibliographic review 28 articles Spanish English, related subject, from databases such as SciELO, Pubmed, Scopus, Springer, where more than 60% are last 6 years, carried out.Results: epidemiological data show high negative impact on obstetric neonatal health these entities, emerging problem that has continued affect good results sector. Added neglect prenatal care, lack preparation/skills for detection treatment pathologies personnel, knowledge by patients negatively influences diagnosis. Education is an important means address reproductive problems; proper understanding disorder contributes its prevention, control management.Conclusions: constitute diverse group cause maternal fetal death. Health education through population-based interventions care early

Language: Английский

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Probiotic‐rich bean sprouts alleviate oxidative stress and inflammation induced by a diet with an increased fat‐to‐carbohydrate energy ratio

International Journal of Food Science & Technology, Journal Year: 2024, Volume and Issue: 59(10), P. 7263 - 7275

Published: Aug. 19, 2024

Summary The rat's model evaluated the function of sprouted beans enriched with probiotic Lactiplantibacillus plantarum 299v in alleviating dyslipidaemia, inflammation and disturbed redox homeostasis caused by a high‐lard diet. Sprouted improved total antioxidant capacity serum liver, regardless whether feeds had higher content low‐molecular antioxidants or were additionally probiotics. reduction (lowered level C‐reactive protein) restoration triglycerides cholesterol to levels recorded control group (AIN‐93M) especially observed supplemented adzuki bean. Introducing legumes (both probiotic‐rich) microbiota activity affected highest, desirable urease (by 80%) tryptophanase 78%) was found groups fed probiotic‐rich mung bean sprouts respectively. improve metabolism individuals subjected diet an increased fat‐to‐carbohydrate energy ratio, concerning oxidative stress injury activity.

Language: Английский

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Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1324 - 1324

Published: Oct. 30, 2024

Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT's antioxidant properties positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, oxidative stress. This study investigates for first time derivative from GT, i.e., juice (GTJ), which could be candidate development as functional food. We GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, known peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, using High-Performance Liquid Chromatography (HPLC)-mass spectrometry. Then, high-fat-diet (HFD) rat model, we assessed impact daily supplementation in addressing MetS. outlined that GTJ improved body weight leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic stress, steatosis HFD rats. Furthermore, enhances transcription PPAR-α, thus putatively promoting acid oxidation metabolism. These findings suggest mitigates lipidic accumulation halters species level through PPAR-α activation. Our underscores protective against MetS, highlighting future nutraceutical improving dysmetabolism associated alterations.

Language: Английский

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Maternal Dietary Improvement or Leptin Supplementation During Suckling Mitigates the Long-Term Impact of Maternal Obesogenic Conditions on Inflammatory and Oxidative Stress Biomarkers in the Offspring of Diet-Induced Obese Rats

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11876 - 11876

Published: Nov. 5, 2024

This study investigates the impact of maternal nutrition during lactation on inflammation and oxidative stress in offspring diet-induced obese rats, along with potential benefits leptin supplementation suckling. Dams were fed either a standard diet (SD), western (WD) before gestation (WD-dams), or WD switched to an SD (Rev-dams). Offspring supplemented vehicle suckling then until four months. Rev-dams exhibited improved metabolic indicators, including lower body weight, reduced plasma levels TNF-alpha, higher adiponectin/leptin (A/L) ratio, enhanced liver antioxidant defenses, decreased markers white adipose tissue (WAT) compared WD-dams, sex differences. Leptin further modulated these markers, reducing WAT (e.g., hepatic

Language: Английский

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Cinnamon (Cinnamomum zeylanicum) Aqueous Extract Regulates the Parameters of Metabolic Syndrome in a Model of Wistar Rats with a Diet High in Fat and Fructose

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

To identify the effect of

Language: Английский

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Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression

Published: May 10, 2023

Abstract: Nonalcoholic fatty liver disease, characterized by the lipid accumulation within hepatocytes exceeding 5% of weight, is strictly related to metabolic disorders and obesity diabetes represents a health emergency worldwide. Being not available any standard therapy for NAFLD, key role ascribed lifestyle intervention including phytonutrient intake prevent NAFLD development progression. We have used rat model evaluate effect dietary supplementation with red tomato golden tomato, patented mix fruit different degrees ripeness, particularly rich in naringenin chlorogenic acid, after steatosis development. assessed ef-fects on body profile, hepatic correlation between amelioration all parameters gene expression was evidenced. found that genes mainly up regulated tomatoes administration were HNF4, Lepr GK, able condition homeostasis. Our results suggest there tomatoes, as nutraceutical approach prevention therapy.

Language: Английский

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Estado del arte: Nuevos biomarcadores en el diagnóstico del Síndrome Metabólico

LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades, Journal Year: 2023, Volume and Issue: 4(2)

Published: Aug. 31, 2023

El síndrome metabólico es una entidad clínica compleja que conlleva un alto riesgo de enfermedades cardiovasculares y diabetes tipo 2. En este artículo revisión sistemática, se analiza la investigación nuevos biomarcadores para el diagnóstico temprano preciso del metabólico. Se realizó búsqueda exhaustiva en bases datos científicas seleccionaron estudios relevantes sobre emergentes. La creciente prevalencia ha impulsado más sensibles específicos detección temprana manejo eficaz. adiponectina surgido como biomarcador potencialmente valioso, ya han mostrado su relación con cardiovascular. Marcadores inflamación proteína C reactiva (PCR) interleucina-6 (IL-6) también investigan por asociación crónica ácido úrico otro emergente, relacionado resistencia a insulina transportadora ésteres colesterol (CETP) considera indicador dislipidemia Además, los microARNs (miR-33a miR-122) pueden ser homeostasis lipídica glucídica, sugiriendo uso biomarcadores. identificación promete Sin embargo, subraya necesidad validen establezcan utilidad clínica. Este enfoque tiene potencial mejorar pronóstico esta afección.

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Association between comprehensive dietary antioxidant index and metabolic syndrome and its components: findings from the 2003–2018 NHANES data (Preprint)

Published: Nov. 24, 2023

The relationship between Composite Dietary Antioxidant Index (CDAI) and metabolic syndrome (MetS) remains unclear. This study used data from the NHANES database on 5,493 participants aged 60 years or above 2003 to 2018 assess CDAI MetS. MetS are defined based criteria proposed by third report of National Cholesterol Education Program Adult Group. scoring method established Wright was adjusted calculate CDAI. We divided scores into 4 quantiles analyzed using multiple logistic regression restricted cubic spline. Our findings showed that inversely associated with significantly affected waist circumference, blood pressure, triglyceride levels. highest quartile multi-factor OR values 95% confidence interval (CI) MetS, pressure triglycerides were 0.97 (0.94-0.99), 0.96 (0.93-1.00), (0.95-0.99), 0.95 (0.93-0.98), respectively. In addition, subgroup analyses female high less prone develop obesity, hypertension than male. cross-sectional highlighted dietary antioxidant intake is strongly Further research needs be conducted confirm this consequence.

Language: Английский

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