Antihyperglycemic Potential of Quercetin-3-glucoside Isolated from Leucaena leucocephala Seedpods via the SIRT1/AMPK/GLUT4 Signaling Cascade

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

(Lam.) de Wit, a traditional medicinal plant, has been reported among the ethnic communities of Mexico, Indonesia, China, and India for treatment diabetes, obesity, related complications. This study investigates antihyperglycemic activity plant its isolated active compound quercetin-3-glucoside. Further, bioactivity guided marker assisted development an enriched bioactive fraction toward enhancing insulin sensitization was carried out. The also found to contain 397.96 mg/g quercetin-3-glucoside along with three other compounds, which were identified. Quercetin-3-glucoside, out four compounds from showed most significant when tested in palmitate-induced insulin-resistant C2C12 myotubes. upregulation sirtuin1 (SIRT1) followed by enhancement insulin-dependent signaling molecules SIRT1/AMPK/PGC1-α GLUT4 translocation. Molecular dynamics studies having stable interactions SIRT1 protein. associated enhanced sensitivity skeletal muscle, increasing glucose uptake muscle cells. prepared modulated SIRT1/AMPK/GLUT4 pathway. findings present may find future application botanical or phytopharmaceutical drugs traditionally important

Language: Английский

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A ‘‘Turn-on’’ Al(III)-Mediated Fluorescent Micro-Probe for Quercetin Sensing

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 420, P. 136497 - 136497

Published: Aug. 23, 2024

Language: Английский

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Multimodal applications of green carbon dots derived from Potentilla indica (mock strawberry): Antioxidant, antimicrobial, and quenching based quercetin sensor

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 114216 - 114216

Published: Sept. 1, 2024

Language: Английский

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Senna alata: Phytochemistry, Antioxidant, Thrombolytic, Anti-inflammatory, Cytotoxicity, Antibacterial activity, and GC-MS analysis

Jordan Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 17(3), P. 549 - 566

Published: Sept. 24, 2024

Objective: Nepal's medicinal herbs are rich in cultural importance and have several uses. Senna alata, a plant belonging to the Leguminosae family, is prized for its aesthetic therapeutic qualities. The goal of study was extract alata leaves using solvent macerations. Methods: aims evaluate phytochemistry, total phenolic flavonoid levels, antioxidant qualities vitro, anti-inflammatory effects, cytotoxicity, anti-thrombolytic potential, antibacterial activity, variety methodologies were employed. Results: extractive values determined as 1.58%, 0.78%, 5.92% hexane, ethyl acetate, methanol, respectively. GC-MS analysis revealed major compounds such 3-Methylmannoside, Neophytadiene, Campesterol, Vitamin E leaf extract. Qualitative phytochemical screening confirmed presence tannins, carbohydrates, flavonoids, cardiac glycosides, saponins methanol contents 46.36±4.5 mg GAE/g 480.4±3.055 QE/g dried extract, exhibited significant activities, with IC50 29.81 9.93, Additionally, it demonstrated cytotoxic activity an LC50 value 767.85 brine shrimp bioassay. In terms thrombolytic showed clot lysis percentages 7.89% 10.13% at concentrations 10 mg/ml 25 mg/ml, Conclusion: methanolic displayed including antioxidant, anti-inflammatory, cytotoxic, thrombolytic, effects. bioactive compounds, by analysis, further supports plant's potential use.

Language: Английский

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Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress accelerate ageing.

Language: Английский

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