Antioxidant Properties of Orange Peel and Their Implications for Health: A Comprehensive Review DOI Open Access

Vishwakarma Shrinath,

Supriya Singh Gaur, Kamaldeep Kaur

et al.

Journal of Food Chemistry and Nanotechnology, Journal Year: 2023, Volume and Issue: 9

Published: Nov. 15, 2023

Despite being historically relegated as a by-product, orange peel (OP) has gained prominence source of beneficial phytochemicals, such flavonoids, phenolic acids, carotenoids, and limonoids.These compounds collectively confer potent free radical scavenging capabilities, offering robust protection against oxidative stress-induced cellular damage.For instance, OP been considered tale cultural significance for its outstanding properties.Besides, contains great variety antioxidants nutrients that contribute to health-promoting benefits.The present study addresses various methodologies employed in the evaluation antioxidant capability, while also addressing factors influencing bioavailability absorption.Additionally, we underscore diverse health implications associated with consumption OP-derived antioxidants, encompassing their potential mitigate stress-related disorders.Moreover, this work presents methods assessing capacity OP.Specifically, review brings together several essential aspects from perspective.This mainly includes OP, cardiovascular dermatological well-being, bolstering immune system, protecting neurological functions, potentially contributing prevention cancer maintenance gastrointestinal health.Finally, practical dietary suggestions integrating due attention safety considerations.In nutshell highlights incorporation derived OPs into contemporary healthcare approaches promote improved overall health.

Language: Английский

Promising strategies for improving oral bioavailability of poor water-soluble drugs DOI
Bruna Rocha,

Letícia Aparecida de Morais,

Mateus Costa Viana

et al.

Expert Opinion on Drug Discovery, Journal Year: 2023, Volume and Issue: 18(6), P. 615 - 627

Published: May 9, 2023

Oral administration of poorly water-soluble drugs (PWSDs) is generally related to low bioavailability, leading high drug doses, multiple side effects, and patient compliance. Thus, different strategies have been developed increase solubility dissolution in the gastrointestinal tract, opening new venues for these drugs.This review outlines current challenges PWSD formulation development overcome oral barriers their bioavailability. Conventional include altering crystalline molecular structures modifying solid dosage forms. In contrast, novel comprise micro- nanostructured systems. Recent representative studies involving how improved bioavailability PWSDs were also reviewed reported.New approaches enhance sought improve water rates, protection by overcoming biological barriers, increased absorption. Still, only a handful focused on quantifying Improving remains an exciting unexplored field research has become important issue successfully developing pharmaceutical products.

Language: Английский

Citations

35
Chitosan: modification and biodegradability of by-products DOI
Great Iruoghene Edo, Emad͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏͏ Yousif, Mohammed H. Al-Mashhadani

et al.

Polymer Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

Citations

12
Olive oil nanoemulsion containing curcumin: antimicrobial agent against multidrug-resistant bacteria DOI Creative Commons
Maine Virgínia Alves Confessor, Maria Anndressa Alves Agreles, Luís André de Almeida Campos

et al.

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Feb. 27, 2024

Abstract The present work aimed to develop, characterize, and evaluate the antibacterial antibiofilm activity of two nanoemulsions (NEs) containing 500 µg/mL curcumin from Curcuma longa (CUR). These NEs, produced with heating, contain olive oil (5%) surfactants tween 80 span (2.5%), water q.s. 100 mL, were stable for 120 days. NE-2-CUR presented Ø 165.40 ± 2.56 nm, PDI 0.254, ζ − 33.20 1.35 mV, pH 6.49, Entrapment Drug Efficiency ( EE ) 99%. NE-4-CUR showed a 105.70 4.13 0.459, 32.10 1.45 6.40 99.29%. Structural characterization was performed using DRX FTIR, thermal DSC TG, morphological SEM, suggesting that there is no significant change in CUR NEs they remain stable. MIC by broth microdilution method nine gram-positive gram-negative bacteria, as well Klebsiella pneumoniae clinical isolates resistant antibiotics biofilm efflux pump producers. mostly bacteriostatic profile. varied between 125 250 µg/mL. most sensitive bacteria Staphylococcus aureus Enterococcus faecalis , which ceftazidime (CAZ) interaction also evaluated against K. Checkerboard method. synergistic or additive profile; reduction CAZ MICs 256 times (K26-A2) 2 (K29-A2). Furthermore, inhibited these biofilms formation. MBIC ranging 15.625 Thus, physicochemical characteristics suitable future trials, enhancing activity, thus becoming promising strategy treatment bacterial infections caused multidrug-resistant . Key points • trials. synergistic/additive profile, when associated ceftazidime. formation isolates.

Language: Английский

Citations

9
Albumin–Rutin Nanoparticles: Design, Characterization, and Biophysical Evaluation DOI Open Access
Claudia G. Chilom, Adriana Bălan, Teodor Adrian Enache

et al.

Coatings, Journal Year: 2024, Volume and Issue: 14(2), P. 220 - 220

Published: Feb. 10, 2024

The bioavailability of the administered drugs that reach systemic circulation is first point in resolving pathology patients. Albumin-based nanoparticles represent an increasingly used strategy to deliver cancer into cells otherwise cannot overcome biological barriers. In this work, rutin (Ru), a flavonoid with anticancer and antioxidant potential, was incorporated bovine serum albumin (BSA-Ru NPs), developed using desolvation method, entire system characterized evaluated by scanning electron microscopy (SEM), atomic force (AFM), UV–Vis absorption spectroscopy. results showed BSA BSA–Ru NPs are uniformly distributed, have relatively large sizes, time stability more than 60%. Furthermore, effect these nanohybrids on thermal liposomal membranes surface plasmon resonance (SPR), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS). viability evaluation assessed tetrazolium salt (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) protocol fibroblast L929 line high level biocompatibility, confirmed SEM results, found.

Language: Английский

Citations

7
Effectiveness of ammonium-based deep eutectic solvents in extracting polyphenol from Chlorella vulgaris DOI
Mohamad Hamdi Zainal-Abidin,

Jia Jia Eng,

Khairunnisa’ Khairuzi

et al.

Algal Research, Journal Year: 2024, Volume and Issue: 79, P. 103436 - 103436

Published: Feb. 23, 2024

Language: Английский

Citations

5
Preparation and characterization of agarose-sodium alginate hydrogel beads for the co-encapsulation of lycopene and resveratrol nanoemulsion DOI
Mingyuan Li, Xinyi Li,

Hongmeng Ren

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133753 - 133753

Published: July 31, 2024

Language: Английский

Citations

3
Characterization of Alpha Mangostin Loaded-Mesoporous Silica Nanoparticle and the Impact on Dissolution and Physical Stability DOI Creative Commons
Diah Lia Aulifa,

Adam Saepudin,

Paul Margaretha

et al.

Nanotechnology Science and Applications, Journal Year: 2025, Volume and Issue: Volume 18, P. 1 - 13

Published: Jan. 1, 2025

Purpose: Improving drug solubility is crucial in formulating poorly water-soluble drugs, especially for oral administration. The incorporation of drugs into mesoporous silica nanoparticles (MSN) widely used the pharmaceutical industry to improve physical stability and solubility. Therefore, this study aimed elucidate mechanism within MSN, as well evaluate impact on dissolution stability. Methods: Alpha mangostin (AM) was adopted a model drug, while MSN with pore size 45 Å (MSN45) 120 (MSN120) were Mesoporous materials. AM-loaded (AM/MSN45 AM/MSN120) prepared by solvent evaporation method. Results: amorphization AM/MSN45 AM/MSN120 confirmed halo pattern observed powder X-ray diffraction absence melting peak glass transition AM DSC curves. This signified successful MSN. FT-IR measurements suggested formation hydrogen bond interaction between carbonyl group surface In test, presence improved rate generated supersaturation AM. However, difference pores could affect profile Additionally, it retained patterns after 30 d storage at 25 o C 0% RH. Conclusion: conclusion, significantly Keywords: silica, alpha mangostin, amorphization, dissolution,

Language: Английский

Citations

0
Binding of the commonly used antioxidants (quercetin, resveratrol, and dihydrolipoic acid) to major circulating proteins – spectroscopic and in silico docking and molecular dynamic simulation studies DOI
Miloš Šunderić, Vladimir Šukalović, Ana Penezić

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 3, 2025

Poor bioavailability and reduced stability are the main drawbacks to efficiently utilizing many naturally occurring antioxidants, so their binding circulatory proteins is essential. This work investigated whether major human proteins, besides albumin, including transferrin, alpha-2-macroglobulin, fibrinogen, bind widely consumed antioxidants food supplements, quercetin, trans-resveratrol, dihydrolipoic acid, thus filling gap of detailed pharmacokinetic properties these supplements. Detailed examination protein structural functional changes that occur upon ligand was analyzed by spectroscopic methods in silico docking molecular dynamic simulation studies on model consists protein/antioxidant pair with highest affinity constant. It found alpha-2-macroglobulin binds trans-resveratrol (Ka 4.5 x 104 M-1). In results revealed four potential sites between hydrogen bonds being crucial for binding, while other observed interactions (primarily aromatic interactions) secondary importance. The leads mutual protection both molecules from oxidative stress significantly increased hidrosolubility resveratrol, which could serve increase bioactivity resveratrol circulation.

Language: Английский

Citations

0
Assembly of phenylaminopyrrolo[1,2-a]pyrazinium salts from N-allenylpyrrole-2-carbaldehydes and phenylhydrazine in the presence of acids DOI
Elena A. Gyrgenova,

S. V. Martynovskaya,

Igor Ushakov

et al.

Russian Chemical Bulletin, Journal Year: 2025, Volume and Issue: 74(1), P. 143 - 150

Published: Jan. 1, 2025

Language: Английский

Citations

0
Spermacoce alata Aubl. Essential Oil: Chemical Composition, In Vitro Antioxidant Activity, and Inhibitory Effects of Acetylcholinesterase, α-Glucosidase and β-Lactamase DOI Creative Commons
Xinyu Zhu, Jiadong Zhu, Ziyue Xu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2869 - 2869

Published: June 16, 2024

Spermacoce alata Aubl. is widely available in the market as traditional Chinese medicine and animal feed, due to its properties of clearing heat treating malaria high-protein crude fiber content. In this study, essential oil S. was obtained through hydrodistillation. GC–MS GC–FID methods were used identify chemical components their relative abundance. Furthermore, antioxidant capacity measured using DPPH, ABTS, FRAP assays, inhibitory effects acetylcholinesterase, α-glucosidase, β-lactamase also evaluated. A total 67 compounds identified, with major constituents being palmitic acid (30.74%), linoleic (16.13%), phenylheptatriyne (8.07%). The exhibited moderate activity against DPPH (IC50 > 10 mg/mL), while IC50 value for ABTS assay 3.84 ± 2.12 mg/mL 87.22 12.22 µM/g. Additionally, showed anti-acetylcholinesterase = 286.0 79.04 μg/mL), significant anti-α-glucosidase 174.7 13.12 potent anti-β-lactamase 37.56 3.48 μg/mL). results suggest that has potential application pharmacology, warranting further exploration investigation.

Language: Английский

Citations

3