Circadian rhythm disruption: a potential trigger in Parkinson’s disease pathogenesis

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 30, 2024

Parkinson's disease (PD) is a neurodegenerative characterized by the gradual loss of dopaminergic neurons in substantia nigra pars compacta (SNpc), abnormal accumulation α-synuclein (α-syn), and activation microglia leading to neuroinflammation. Disturbances circadian rhythm play significant role PD, with most non-motor symptoms associated disruptions rhythm. These disturbances can be observed years before motor appear are marked emergence related such as rapid eye movement sleep behavior disorder (RBD), restless leg syndrome (RLS), excessive daytime sleepiness (EDS), depression anxiety, changes blood pressure, gastrointestinal dysfunction, urinary problems. Circadian disruption precedes onset contributes progression PD. In brief, this article outlines triggering PD at cellular molecular levels, well its clinical manifestations. It also explores how research contribute preventing from current future perspectives.

Language: Английский

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The Park Sleep subtype in Parkinson’s disease: from concept to clinic

Expert Opinion on Pharmacotherapy, Journal Year: 2023, Volume and Issue: 24(15), P. 1725 - 1736

Published: Aug. 10, 2023

Introduction The heterogeneity of Parkinson's disease (PD) is evident from descriptions non-motor (NMS) subtypes and Park Sleep, originally identified by Sauerbier et al. 2016, one such clinical subtype associated with the predominant presentation sleep dysfunctions including excessive daytime sleepiness (EDS), along insomnia.Areas covered A literature search was conducted using PubMed, Medline, Embase, Web Science databases, accessed between 1 February 2023 28 March 2023. In this review, we describe Sleep related 'tests' ranging polysomnography to investigational neuromelanin MRI brain scans some tissue-based biological markers.Expert Opinion Cholinergic, noradrenergic, serotonergic systems are dominantly affected in PD. hypothesized be primarily deficit, clinically manifesting as somnolence narcoleptic events (sleep attacks), or without rapid eye movement behavior disorder (RBD). clinic, recognition may drive lifestyle changes (e.g. driving) therapy adjustments patients sensitive dopamine D3 active agonists, ropinirole pramipexole. Specific dashboard scores based personalized management options need implemented include pharmacological, non-pharmacological, linked advice.

Language: Английский

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The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

Aging and Disease, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Intrinsic biological clocks drive the circadian rhythm, which coordinates physiological and pathophysiological processes in body. Recently, a bidirectional relationship between rhythms several neurological diseases has been reported. Neurological can lead to disruption of homeostasis, thereby increasing disease severity. Therefore, optimizing current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, targeted interventions, offer promising opportunity for better clinical outcomes precision medicine. In this review, we provide detailed implications rhythm bench-to-bedside approaches. Furthermore, based on unsatisfactory outcomes, critically discuss potential may encourage more studies discipline, with hope improving treatment efficacy diseases.

Language: Английский

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Effects of melatonin against acute kidney injury: A systematic review and meta-analysis

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 120, P. 110372 - 110372

Published: June 6, 2023

Language: Английский

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Changes in Melatonin Concentration in a Clinical Observation Study under the Influence of Low-Frequency Magnetic Fields (Magnetic Stimulation in Men with Low Back Pain)—Results of Changes in an Eight-Point Circadian Profile

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15860 - 15860

Published: Nov. 1, 2023

The aim of this study was to assess the changes in melatonin concentration under influence magnetic stimulation men with low back pain. A total 15 were used study, divided into two groups. In Group 1, consisting seven men, M1P1 Viofor JPS program twice a day for 8 min, at 08:00 and 13:00. 2, eight M2P2 once 12 min 10:00. application subjected whole body patients. treatments both groups lasted 3 weeks, 5 days each week, breaks on weekends. diurnal profile determined before exposure after last treatment, as well one-month follow-up. Blood samples collected times day. programs, did not reduce nocturnal peak concentration. After exposure, prolonged secretion observed until morning hours. impact field maintained 1 month end application. effect from application, which confirms thesis about occurrence phenomenon biological hysteresis. parameters fields, system, time length may affect melatonin.

Language: Английский

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Changes in the Secretion of Melatonin and Selected Adipokines during the Progression of Parkinson’s Disease—Preliminary Studies

Metabolites, Journal Year: 2023, Volume and Issue: 13(5), P. 668 - 668

Published: May 18, 2023

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases affecting elderly people. Considering gap in literature on melatonin and adipokine levels PD patients at various stages disease, we conducted a study to investigate selected parameters disease’s early (ES) advanced (AS) stages. Melatonin, leptin, adiponectin, resistin concentrations were measured blood serum 20 without dyskinesia (ES), 24 with (AS), healthy volunteers as control group (CG). The data analyzed using ANOVA. Melatonin was significantly lower ES (p < 0.05) higher AS compared CG. level leptin increased both 0.001) versus CG, while only 0.05). Higher found ES. main findings include changes inflammatory markers’ during surprising increase patients. Further research necessary, which will be aimed modulating secretion adipokines treatment target for PD.

Language: Английский

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Smart Sleep Monitoring: IoMT and GRU for Effective Sleep Disorders Management

2020 4th International Conference on Electronics, Communication and Aerospace Technology (ICECA), Journal Year: 2023, Volume and Issue: unknown, P. 1767 - 1773

Published: Nov. 22, 2023

Sleep disorders management is paramount for maintaining overall well-being. In response to the limitations of traditional approaches, we present an innovative solution that leverages synergy Internet Medical Things (IoMT) and Gated Recurrent Unit (GRU)-based data analytics, leading smart sleep monitoring effectively addresses disorders. The conventional methods often fall short due their inability provide continuous personalized insights tailored individual needs.Our proposed work offers a comprehensive these challenges by introducing IoMT-enabled system. This system integrates wearable devices sensors continuously gather transmit sleep-related in real-time. uniqueness our approach lies integration GRU, sophisticated deep learning algorithm, which excels at capturing analyzing sequential patterns. GRU enables us comprehensively analyze collected data, accurately classifying stages, detecting anomalies, predicting potential disruptions. To validate effectiveness IoMT GRU-based approach, We carried out trials with individuals who had been diagnosed range disorders, encompassing conditions such as insomnia, obstructive apnea, idiopathic narcolepsy. results demonstrate impressive average efficiency improvement 18%. enhancement achieved through generation interventions stem from derived analysis. Our thus not only improves but also solutions address specific faced individuals. real-time nature IoMT, combined advanced pattern recognition capabilities equips actionable insights, recommendations, effective solutions, significantly enhancing quality

Language: Английский

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The Non-Motor Prodromal Symptoms of Parkinson's Disease: A Review

Scientific Journal of King Faisal University Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 25 - 29

Published: Jan. 23, 2024

Parkinson's disease is a common progressive neurodegenerative disorder with both motor and non-motor symptoms. There no clear etiology, it has cure. The features often precede the symptoms by many years, so they are considered prodromal of disease. These include olfactory dysfunction, constipation, sleep problems, depression. purpose this study to review literature on their role from early stages throughout disease's development. discusses several aspects related disease: prevalence in patients, pathophysiology, treatment, if possible, symptoms' effect diagnosis, prognosis, management disease, addition impact patients' quality life. More studies required precisely pinpoint timing onset modify diagnostic criteria for accordingly. KEYWORDS depression, gastrointestinal dysfunctions, hyposmia, disturbances

Language: Английский

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Ameliorative role of diets fortified with Artocarpus altilis in a Drosophila melanogaster model of aluminum chloride-induced neurotoxicity

Clinical Phytoscience, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 4, 2024

Abstract Backgrounds: Artocarpus altilis (breadfruit) belongs to the family Moraceae. possesses antioxidative, anti-inflammatory, and anti-proliferative properties. Aluminum (Al) is extensively utilized for consumer products, cooking utensils, pharmaceuticals, industries. Indication neurotoxicity of Al investigated in various studies, notwithstanding precise mechanisms toxicity are yet be fully elucidated, and, which requires novel therapy. In this study, we determined ameliorative role on aluminum chloride-induced Drosophila melanogaster . Methods Varying concentration extract were used formulate diets 6 groups flies. Group 1 contained basal diet, group 2 diet aluminium chloride (AlCl 3 ), + 0.1% unseeded breadfruit (UBF), 4 1% breadfruit, 5 AlCl3 breadfruit. Assays such as acetylcholinesterase activity, malondialdehyde (MDA) level, catalase superoxide dismutase (SOD) activity carried out after 7 days exposure respectively. Results The results showed low MDA level high SOD pretreated post-treated flies with compared normal negative control Conclusions Taken together, a promising prophylactic, antiacetylcholinesterase, antioxidant plant prevention, management treatment neurodegenerative diseases. Graphical

Language: Английский

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Sleep-promotion of probiotics-fermented Gastrodia elata Bl.: Chemical variation and omics exploration.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Fermentation of Chinese herbal medicines (CHM) could enhance its bioactivities. We hypothesized probiotic-fermented GE with better potential to alleviate insomnia than thatof unfermented, thus the changes in chemical composition and insomnia-alleviating effects mechanisms fermented on PTZ-induced zebrafish were explored via HPLC LCMS, phenotypic, transcriptomic, metabolomics analysis. The results demonstrated that probiotic performed unfermented increasing content composition, reducing displacement, average speed, number apoptotic cells insomnia. Metabolomic investigation showed anti-insomnia effect was related regulating pathways actin cytoskeleton neuroactive ligand-receptor interactions. Transcriptomic RT-qPCR analysis revealed SFL significantly modulated expression levels neurod1, msh2, msh3, recql4, ercc5, rad5lc, rev3l, which are mainly involved neuron differentiation DNA repair. Collectively, as a functional food, Fermented possessed for alleviation.

Language: Английский

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