Identification of novel key markers that are induced during traumatic brain injury in mice DOI Creative Commons
Yucheng Li,

N. Li,

Changjiao Luan

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e15981 - e15981

Published: Aug. 25, 2023

Traumatic brain injury (TBI) has emerged as an increasing public health problem but not been well studied, particularly the mechanisms of cellular behaviors during TBI. In this study, we established ischemia/reperfusion (I/R) mice model using transient middle cerebral artery occlusion (tMCAO) strategy. After then, RNA-sequencing frontal lobes was performed to screen key inducers To further verify selected genes, collected peripheral blood mononuclear cells (PBMCs) from TBI patients within 24 h who attended intensive care unit (ICU) in Affiliated Hospital Yangzhou University and analyzed genes expression RT-qPCR. Finally, receiver operator characteristic (ROC) curves co-expression with senescence markers were applied evaluate predictive value genes. A total six screened out based on their novelty implications apoptosis signaling. RT-qPCR analysis PBMCs showed all up-regulated after comparing healthy volunteers hospital for physical examination. The area under ROC (AUC) >0.7, scores significantly positive. We thus identified TGM1, TGM2, ATF3, RCN3, ORAI1 ITPR3 novel that are induced TBI, these may also serve potential predictors progression

Language: Английский

Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives DOI

Margrethe A. Olesen,

Francisca Villavicencio-Tejo,

Víctor Cuevas-Espinoza

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102594 - 102594

Published: Nov. 1, 2024

Language: Английский

Citations

1
Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation DOI Creative Commons

Esteban Díaz‐Jara,

Katherine Pereyra,

Sinay Vicencio

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 69, P. 102992 - 102992

Published: Dec. 12, 2023

In mammals, central chemoreception plays a crucial role in the regulation of breathing function both health and disease conditions. Recently, correlation between high levels superoxide anion (O

Language: Английский

Citations

2
Identification of novel key markers that are induced during traumatic brain injury in mice DOI Creative Commons
Yucheng Li,

N. Li,

Changjiao Luan

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e15981 - e15981

Published: Aug. 25, 2023

Traumatic brain injury (TBI) has emerged as an increasing public health problem but not been well studied, particularly the mechanisms of cellular behaviors during TBI. In this study, we established ischemia/reperfusion (I/R) mice model using transient middle cerebral artery occlusion (tMCAO) strategy. After then, RNA-sequencing frontal lobes was performed to screen key inducers To further verify selected genes, collected peripheral blood mononuclear cells (PBMCs) from TBI patients within 24 h who attended intensive care unit (ICU) in Affiliated Hospital Yangzhou University and analyzed genes expression RT-qPCR. Finally, receiver operator characteristic (ROC) curves co-expression with senescence markers were applied evaluate predictive value genes. A total six screened out based on their novelty implications apoptosis signaling. RT-qPCR analysis PBMCs showed all up-regulated after comparing healthy volunteers hospital for physical examination. The area under ROC (AUC) >0.7, scores significantly positive. We thus identified TGM1, TGM2, ATF3, RCN3, ORAI1 ITPR3 novel that are induced TBI, these may also serve potential predictors progression

Language: Английский

Citations

0