Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426,
Journal Year:
2024,
Volume and Issue:
7(8), P. 375 - 385
Published: Aug. 31, 2024
The
impact
of
oxidative
stress
in
the
pathogenesis
various
diseases
is
well
known.
Oxidative
occurs
when
there
an
imbalance
between
production
reactive
oxygen
species
(ROS)
and
ability
a
biological
system
to
detoxify
these
intermediates
or
repair
resulting
damage.
Polyphenols,
diverse
group
compounds
with
antioxidant
properties,
help
reduce
damage
by
ROS.
They
are
abundant
fruits,
vegetables,
tea,
coffee,
wine,
other
plant-based
foods.
mechanisms
their
activity
related
regulate
cellular
signaling
pathways,
metal
chelation,
mitochondrial
protection,
while
modulating
enzyme
exhibiting
anti-inflammatory
effects.
Polyphenols
can
also
through
ROS
scavenging,
direct
neutralization,
enhancing
defenses
within
cells.
It
has
been
established
that
polyphenols
derived
from
plant
do
not
harm
metabolism
normal
cells,
but
involved
metabolic
pathways
diseased
which
high
redox
sensitivity.
Incorporating
polyphenol-rich
foods
into
diet
beneficial
for
maintaining
overall
health
reducing
risk
stress-related
diseases.
Researchers
exploring
therapeutic
potential
as
dietary
supplements
functional
medical
applications.
This
review
discusses
origin,
structure,
benefits,
application
medicine
food
industry.
Keywords:
biologically
active
compounds,
polyphenols,
stress,
activity,
food.
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1154 - 1154
Published: March 26, 2025
The
Montmorency
tart
cherry
(Prunus
cerasus
L.,
MTC)
polyphenols
may
contribute
to
reduced
inflammation
and
oxidative
stress
biomarkers
in
the
body.
However,
a
comprehensive
polyphenolic
profile
of
MTC
products
is
lacking.
This
study
provides
comparative
analysis
distribution
individual
anthocyanins,
flavonols,
flavanols,
hydroxycinnamic
acids,
hydroxybenzoic
acids
five
(frozen
raw
fruit,
freeze-dried
powder,
sweet
dried
unsweetened
juice
concentrate).
Twenty-three
were
detected,
21
positively
identified.
Results
from
three
replicates
indicate
that
frozen
has
most
total
polyphenolics.
Juice
concentrate,
MTC,
contained
26%,
40%,
60%,
77%
fewer
polyphenolics
than
MTC.
Hydroxycinnamic
anthocyanins
predominated,
accounting
for
87-99%
products.
Chlorogenic
acid,
rutin,
cyanidin-3-sophoroside,
feruloquinic
ferulic
coumaric
acid
isomers
noteworthy
predominated
(82%),
(74%),
concentrate
(66%),
frozen-raw
(54%)
Flavonols
powder
(52%).
Anthocyanins,
particularly
cyanidin
glycosides,
important
cherries
(18%)
but
less
so
other
These
findings
highlight
variability
emphasize
importance
selecting
appropriate
specific
health
benefits.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(10), P. 2203 - 2203
Published: May 18, 2025
Flavanones,
a
key
subclass
of
flavonoids,
exhibit
wide
range
biological
activities,
including
antioxidant,
anti-inflammatory,
and
neuroprotective
properties.
Predominantly
found
in
citrus
fruits,
they
occur
both
aglycone
glycosylated
forms,
undergoing
extensive
metabolic
transformation
upon
ingestion.
Recent
evidence
suggests
that
flavanones,
such
as
naringenin
hesperidin,
influence
gut
microbiota
composition,
fostering
balance
between
beneficial
pathogenic
bacterial
populations.
The
plays
pivotal
role
regulating
the
gut–brain
axis,
impacting
cognitive
function
through
production
short-chain
fatty
acids
(SCFAs),
neurotransmitters,
anti-inflammatory
cytokines.
modulation
microbiome
by
flavanones
has
been
associated
with
improvements
performance
reduced
risk
neurodegenerative
disorders.
This
review
provides
comprehensive
analysis
characteristics
major
their
pathways,
impact
on
function.
It
covers
fundamental
mechanisms
which
exert
effects,
well
potential
therapeutic
applications
for
brain
health
neuroprotection.
Despite
promising
findings,
further
research
is
needed
to
determine
optimal
dosages,
strategies
enhance
bioavailability,
long-term
safety
profiles.
Bioinformatics and Biology Insights,
Journal Year:
2024,
Volume and Issue:
18
Published: Jan. 1, 2024
Breast
cancer
is
the
most
commonly
diagnosed
globally,
with
highest
incidence
of
breast
occurring
in
Asian
countries
including
Indonesia.
Among
types
cancer,
estrogen
receptor
(ER)-positive
subtype
which
prominent
alpha
(
ERα)
and
heat
shock
protein
90
HSP90)
overexpression
genes
becomes
prevalent
than
others,
approximately
75%
all
cases.
ERα
HSP90
play
a
role
activities
tumor
growth,
invasion,
metastasis
mechanism.
Propolis,
natural
bee
product,
has
been
explored
for
its
anticancer
activity.
However,
there
lack
studies
that
evaluated
potential
inhibitor
from
propolis
compounds
to
proteins.
Therefore,
this
article
focuses
on
examining
correlation
between
HSP90’s
investigating
93
unique
compositions
inhibiting
these
using
silico
approaches.
This
study
revealed
positive
disease
development.
Furthermore,
we
also
found
novel
bioactive
against
through
binding
HSP90;
they
were
3’,4’,7-trihydroxyisoflavone
baicalein-7-O-β-D
glucopyranoside,
respectively.
Further
research
needed
elucidate
deeper
mechanisms
activity
real
biological
system
develop
new
drug
treatments.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(9), P. 2003 - 2003
Published: April 26, 2024
The
aim
of
this
study
was
to
investigate
the
potential
Amaranthus
cruentus
flavonoids
(quercetin,
kaempferol,
catechin,
hesperetin,
naringenin,
hesperidin,
and
naringin),
cinnamic
acid
derivatives
(p-coumaric
acid,
ferulic
caffeic
acid),
benzoic
acids
(vanillic
4-hydroxybenzoic
acid)
as
antioxidants,
antidiabetic,
antihypertensive
agents.
An
analytical
method
for
simultaneous
quantification
flavonoids,
derivatives,
metabolomic
analysis
leaves
inflorescences
from
A.
developed
with
HPLC-UV-DAD.
Evaluation
linearity,
limit
detection,
quantitation,
precision,
recovery
used
validate
developed.
Maximum
total
contents
(5.2
mg/g
lyophilized
material)
(0.6
were
found
in
leaves.
Using
UV-Vis
spectrophotometry,
maximum
betacyanin
(74.4
betaxanthin
(31
inflorescences.
leaf
extract
showed
highest
activity
removing
DPPH
radicals.
In
vitro
antidiabetic
extracts
performed
pancreatic
α-glucosidase
intestinal
α-amylase,
compared
acarbose.
Both
exhibited
a
reduction
enzyme
57
74%.
Furthermore,
vivo
tests
on
normoglycemic
murine
models
improved
glucose
homeostasis
after
sucrose
load,
which
significantly
different
control.
angiotensin-converting
contrasted
captopril;
both
53
58%.
induced
45%
relaxation
an
ex
aorta
model.
molecular
docking
analysis,
isoamaranthin
isogomphrenin-I
predictive
binding
affinity
α-glucosidases
(human
maltase-glucoamylase
human
sucrase-isomaltase),
while
catechin
displayed
enzyme.
data
highlights
functional
food.
