Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols DOI Creative Commons
Claudio Medana, Umile Gianfranco Spizzirri,

Valentina Schiavo

et al.

LWT, Journal Year: 2024, Volume and Issue: 208, P. 116666 - 116666

Published: Aug. 24, 2024

The winemaking process generates a large amount of waste which can be profitably converted into resource. In this work, extracts from stalks, lees, and pomace Magliocco canino cv (Vitis Vinifera L.) were obtained using ultrasounds. A comprehensive metabolomics profile was carried out by high-resolving power mass spectrometry hyphenated with liquid chromatography. Fifty-nine compounds annotated successively verified, bearing different chemical classes. Free amino acids quantified in the extracts. Distinction glycosylated polyphenols vs their aglycones accomplished targeted semi-targeted LC-MS methods; then selected polyphenolic biomarkers studied antioxidant activity evaluated vitro human dermal fibroblasts assay, best extract used for synthesis an DX conjugate grafting reaction, to obtain innovative food ingredient endowed improved activity. in-vitro endothelium-dependent vasorelaxation, recorded both stalk lees could exploited development new antihypertensive nutraceuticals.

Language: Английский

Green synthesis and characterization of silver nanoparticles using grape stalk extract DOI

Rosa M. De La Cruz-Puma,

Jaime Vega‐Chacón, Victor Raúl Jauja-Ccana

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 403, P. 124927 - 124927

Published: May 4, 2024

Language: Английский

Citations

8
Formulation of Antioxidant Gummies Based on Gelatin Enriched with Citrus Fruit Peels Extract DOI Creative Commons
Francesca Aiello, Paolino Caputo, Cesare Oliviero Rossi

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(2), P. 320 - 320

Published: Jan. 19, 2024

In this work, the peels of red and blonde oranges as well lemons were efficiently (5.75-9.65% yield) extracted by hydroalcoholic solution with ultrasound assistance employed active molecule sources in preparation functional gummies. Antioxidant performances extracts characterized colorimetric assays, whereas LC-HRMS analyses identified main bioactive compounds (phenolic acids flavonoids). The highest scavenging activity was recorded for lemon extract an aqueous environment (IC

Language: Английский

Citations

6
Synthetic Haemostatic Sealants: Effectiveness, Safety, and In Vivo Applications DOI Creative Commons
Federica Curcio, Paolo Perri,

Paolo Piro

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 288 - 288

Published: Feb. 23, 2024

Rapid haemostasis during surgery is essential when one wants to reduce the duration of operations, need for transfusions, and above all achieve better patient management. The use haemostatic agents, sealants, adhesives improves process by offering several advantages, especially in vascular surgery. These agents vary widely their mechanism action, composition, ease application, adhesion wet or dry tissue, immunogenicity, cost. most used are cyanoacrylate-based glues (Glubran 2) polysaccharide hydrogel-microsphere powder (AristaTMAH). This work based on a retrospective study carried out sample patients with different diseases (FAV, pseudoaneurysm, PICC application) which two sealants were used. aim was assess safety, ability both activate at affected site, also relation chemical-physical characteristics. obtained results showed that application Glubran 2 AristaTMAH as surgical wound closure systems effective safe, success achieved ≥94% anastomoses FAV, 100% stabilization catheters, ≤95% pseudoaneurysms.

Language: Английский

Citations

5
Extraction of Bioactive Compounds from Wine Lees: A Systematic and Bibliometric Review DOI Creative Commons
Filipe de Oliveira Melo, Vanessa Cosme Ferreira, Gerardo F. Barbero

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2060 - 2060

Published: June 28, 2024

The extraction of bioactive compounds from wine lees involves a variety methods, the selection which is crucial to ensure optimal yields. This systematic review, following PRISMA guidelines and utilizing Web Science database, aimed examine current state this field, providing insights for future investigations. search employed strategies with truncation techniques Boolean operators, followed by three-step screening using well-defined eligibility criteria. A bibliometric analysis was conducted identify authors, affiliations, countries/regions, research trends. Thirty references were selected analysis, Spain standing out as main source on topic. majority studies (66%) focused alcoholic fermentation lees, while 33% directed towards malolactic lees. Binary mixtures (ethanol-water) predominant solvents, ultrasound being most used method (31.3%), highest average yields (288.6%) various evaluated compounds, especially flavonoids. potential highlighted, along need further exploring alternative technologies combination methods. Additionally, importance "in vitro" vivo" tests assess well use computational tools optimize molecules responsible activity, emphasized.

Language: Английский

Citations

5
Harnessing Antioxidant-Rich Byproducts from Olive and Wine Industries to Produce Corn Starch Films as Edible Coatings for Minimally Processed Foods DOI

Gabriela Natalia,

E. Pulido Melián, Carolina C. Acebal

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106802 - 106802

Published: May 1, 2025

Language: Английский

Citations

0
Formulation of A Gluten-Free Carob-Based Bakery Product: Evaluation of Glycemic Index, Antioxidant Activity, Rheological Properties, and Sensory Features DOI Creative Commons
Donatella Restuccia, Luigi Esposito, Umile Gianfranco Spizzirri

et al.

Fermentation, Journal Year: 2023, Volume and Issue: 9(8), P. 748 - 748

Published: Aug. 12, 2023

A baked gluten-free pastry was formulated using milk kefir, rice, and different amounts of carob pulp flour, i.e., 20% (B1) 40% (B2). In all cases, B2 showed the most remarkable antioxidant properties in terms total phenolic, phenolic acid, flavonoid content, as well scavenging activity both aqueous organic media. This trend observed over a 6-day storage time. Lower cohesive interactions among dough aggregate domains were recorded flour amount increased. At same time, rigidity decreased order B0 > B1 confirmed by lower textural shown carob-added samples. Sensory analysis overall acceptability for B2, with sweetness, cocoa, gingerbread, rye aroma predominant descriptors. The glycemic index determination better score revealed medium GI value (62), comparison high GIs (115 100, respectively).

Language: Английский

Citations

9
Valorization of the solid fraction of wine lees through optimized accelerated autolysis: Effect of temperature, pH and solid concentration on free-amino acid concentration DOI
Evangelos Kokkinomagoulos,

Asterios Stamkopoulos,

Alexandra-Maria Michaelidou

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 42, P. 101780 - 101780

Published: Sept. 25, 2024

Language: Английский

Citations

2
Red Grape By-Products from the Demarcated Douro Region: Chemical Analysis, Antioxidant Potential and Antimicrobial Activity against Food-Borne Pathogens DOI Creative Commons
Adriana Silva, Raquel Martins, Vanessa Silva

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4708 - 4708

Published: Oct. 4, 2024

Wine production is one of the most important agricultural activities. The winemaking process generates a considerable volume different residues characterized as by-products, such pomace, seeds, stems, and skins. By-products are rich in polyphenols with antioxidant antibacterial properties may act bacteriostatic or bactericidal agents against food-borne pathogens, improving food safety by enhancing antibiotic efficacy reducing bacterial resistance. aim this study was to evaluate phenolic composition activity grape components (skins, stems) from three red varieties (Periquita, Gamay, Donzelinho Tinto) determine their antibiotic-resistant bacteria, including Escherichia coli food-producing animals Listeria monocytogenes products food-related environments. Ten compounds were quantified these varieties, specific found parts grape, acids flavonoids. Flavonoids abundant seeds malvidin-3-O-glucoside being main anthocyanin ethanolic extract showed vitro concentration-dependent reactive species like •NO O2•−. Gamay effective, followed Tinto Periquita. Extracts varying Gram-positive Gram-negative stronger effects on bacteria. L. more susceptible, while E. limited strains. Seeds exhibited strongest activity, stems. results our provide evidence potential particularly sources bioactive properties, offering promising avenues for combating resistance related

Language: Английский

Citations

2
Synthesis and Characterization of a Biopolymer Pectin/Ethanolic Extract from Olive Mill Wastewater: In Vitro Safety and Efficacy Tests on Skin Wound Healing DOI Open Access
Francesca Aiello, Rocco Malivindi,

Marisa Francesca Motta

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15075 - 15075

Published: Oct. 11, 2023

Wound-healing delay is one of the major problems type 2 diabetes, representing also a clinical emergency in non-healing chronic wounds. Natural antioxidants show interesting wound-healing properties, including those extracted from waste derived olive oil production. Olive mill wastewater main by-products oil-making process, and it rich high-value secondary metabolites, mainly hydroxytyrosol. We proposed an eco-friendly extraction method, employing both ultrasound-assisted Soxhlet techniques ethanol as solvent, to recover valuable molecules Roggianella cv (Olea europea L.) wastewater, which was further entrapped pectin polymer via enzymatic reaction using porcine pancreatic lipase. Pectin, combination with other substances, promoted accelerated wound healing demonstrated good potential produce biomedical conjugate for treatment. The antioxidant activity extracts were evaluated against lipophilic (IC50 equal 0.152 mg mL−1) hydrophilic 0.0371 radical species well vitro cytotoxicity NRU, h-CLAT, scratch assay assessment. did not exert hemolytic effects on peripheral blood, demonstrating properties due its ability stimulate cell proliferation dose-dependent manner.

Language: Английский

Citations

4
Enhancing Anthocyanin Extraction from Wine Lees: A Comprehensive Ultrasound-Assisted Optimization Study DOI Creative Commons
Marcelo Andrés Umsza‐Guez, Mercedes Vázquez-Espinosa, Nuria Chinchilla

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2074 - 2074

Published: Dec. 5, 2023

Wine lees, an important by-product of the wine industry, pose a major environmental problem due to enormous quantities solid-liquid waste that are discarded annually without defined applications. In this study, optimization method based on Box-Behnken design with surface response has been carried out obtain extracts high anthocyanin content and potent antioxidant activity. Six variables have considered: %EtOH, temperature, amplitude, cycle, pH, ratio. The developed exhibited repeatability properties intermediate precision, less than 5% CV being achieved. Furthermore, these novel methods were successfully applied diverse lees samples sourced from Cabernet Sauvignon Syrah varieties (Vitis vinifera), resulting in enriched significant noteworthy Additionally, study evaluated influence grape variety, fermentation type (alcoholic or malolactic), sample treatment activity, providing valuable insights for further research application various sectors. potential applications high-quality extend beyond winemaking holding promise fields like medicine, pharmaceuticals, nutraceuticals, thus promoting circular economy mitigating contamination.

Language: Английский

Citations

4