Epithelial Na + Channels Function as Extracellular Sensors DOI
Ossama B. Kashlan, Xue‐Ping Wang, Shaohu Sheng

et al.

Comprehensive physiology, Journal Year: 2024, Volume and Issue: 14(2), P. 1 - 41

Published: March 29, 2024

Abstract The epithelial Na + channel (ENaC) resides on the apical surfaces of specific epithelia in vertebrates and plays a critical role extracellular fluid homeostasis. Evidence that ENaC senses external environment emerged well before molecular identity was reported three decades ago. This article discusses progress toward elucidating mechanisms through which factors regulate function, highlighting insights gained from structural studies related family members. It also reviews our understanding regulation by physiology disease. After familiarizing reader with channel's physiological roles structure, we describe central protein allostery ENaC's sensitivity to environment. We then discuss each directly channel: proteases, cations anions, shear stress, other regulators particular compartments. For regulator, initial observations led discovery, investigating mechanism, pathophysiological implications regulation. © 2024 American Physiological Society. Compr Physiol 14:5407‐5447, 2024.

Language: Английский

Three-Dimensional Bioprinting Applications for Bone Tissue Engineering DOI Creative Commons
Jamie A. Maresca, Derek C. DeMel, Grayson A. Wagner

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(9), P. 1230 - 1230

Published: April 24, 2023

The skeletal system is a key support structure within the body. Bones have unique abilities to grow and regenerate after injury. Some injuries or degeneration of tissues cannot rebound must be repaired by implantation foreign objects following injury disease. This process invasive does not always improve quality life patient. New techniques arisen that can bone replacement repair. 3D bioprinting employs printer capable printing biological materials in multiple directions. potentially requires steps additional structures, which may include use hydrogels for scaffolding. In this review, we discuss normal physiology pathophysiology how adapted further field tissue engineering.

Language: Английский

Citations

24
Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair DOI
Vivian Y. Shi, Elise F. Morgan

Bone, Journal Year: 2024, Volume and Issue: 188, P. 117220 - 117220

Published: Aug. 5, 2024

Language: Английский

Citations

11
Epithelial Na + Channels Function as Extracellular Sensors DOI
Ossama B. Kashlan, Xue‐Ping Wang, Shaohu Sheng

et al.

Comprehensive physiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 41

Published: March 29, 2024

Abstract The epithelial Na + channel (ENaC) resides on the apical surfaces of specific epithelia in vertebrates and plays a critical role extracellular fluid homeostasis. Evidence that ENaC senses external environment emerged well before molecular identity was reported three decades ago. This article discusses progress toward elucidating mechanisms through which factors regulate function, highlighting insights gained from structural studies related family members. It also reviews our understanding regulation by physiology disease. After familiarizing reader with channel's physiological roles structure, we describe central protein allostery ENaC's sensitivity to environment. We then discuss each directly channel: proteases, cations anions, shear stress, other regulators particular compartments. For regulator, initial observations led discovery, investigating mechanism, pathophysiological implications regulation. © 2024 American Physiological Society. Compr Physiol 14:5407‐5447, 2024.

Language: Английский

Citations

7
Ion channels involved in inflammation and pain in osteoarthritis and related musculoskeletal disorders DOI
Csaba Matta, Roland Takács, László Ducza

et al.

AJP Cell Physiology, Journal Year: 2023, Volume and Issue: 325(1), P. C257 - C271

Published: June 12, 2023

Osteoarthritis (OA) is a currently incurable, chronic, progressive, and debilitating musculoskeletal (MSK) condition. One of its hallmark symptoms chronic nociceptive neuropathic pain, which significantly reduces the quality life patients with OA. Although research into pathomechanisms OA pain ongoing several pathways are well understood, true source remains unclear. Ion channels transporters key mediators pain. In this narrative review article, we summarize state-of-the-art in relation to distribution function ion all major synovial joint tissues context generation. We provide an update on likely involved mediating peripheral central nervous system including voltage-gated sodium potassium channels, members transient receptor potential (TRP) channel family, purinergic complexes. focus that have be candidate drug targets for management propose expressed by cells constituent OA-afflicted joints cartilage, bone, synovium, ligament, muscle, should more thoroughly investigated targeted Based findings from recent basic articles as clinical trials, novel directions development future analgesic therapies improve

Language: Английский

Citations

15
Role of TRP Channels in Cancer-Induced Bone Pain DOI Open Access
Flaminia Coluzzi, Maria Sole Scerpa, Elisa Alessandri

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1229 - 1229

Published: Jan. 30, 2025

The burden of cancer is growing in almost every country. Bone metastases significantly affect the prognosis and lead to an increase mortality morbidity. management cancer-induced bone pain (CIBP) still shows various unmet needs. Opioid use burdened by a number possible side effects. Moreover, recent progresses treatment increased life expectancy patients, even those with metastatic disease. In this narrative review, we reported main findings regarding TRP channel function models. cation channels play key role different functions cells, including regulation their potential for metastasization, are involved pathways perception, through peripheral central Genetic deletion decreased sensitivity following tumour cell inoculation. Preclinical data suggest modulators some channels, such as TRPV1, TRPA1, TRPM7 TRPM8. Clinical results scarce; however, physiological modulating remodelling involvement preclinical models have garnered interest areas research last few years, innovative analgesic strategies that may overcome long-term effects opioids.

Language: Английский

Citations

0
Application of biphasic mineralized collagen/polycaprolactone scaffolds in the repair of large load-bearing bone defects: A study in a sheep model DOI

M. Yao,

Jing-chuan Zheng,

Haicheng Wang

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 52, P. 138 - 149

Published: April 21, 2025

Language: Английский

Citations

0
Development of a Novel Macroscopic Regulation and Microscopic Intervention Mode Nanosystem for Osteoporosis Treatment DOI Creative Commons

Shichao Meng,

Qin Liu,

Rong Dai

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101829 - 101829

Published: May 1, 2025

Language: Английский

Citations

0
[Role of Piezo mechanosensitive ion channels in the osteoarticular system]. DOI
Guohui Chen, Yaxing Li, Hui Zhang

et al.

PubMed, Journal Year: 2024, Volume and Issue: 38(2), P. 240 - 248

Published: Feb. 15, 2024

To summarize the role of Piezo mechanosensitive ion channels in osteoarticular system, order to provide reference for subsequent research.

Language: Английский

Citations

1
Recent research advances in pain mechanisms in McCune–Albright syndrome thinking about the pain mechanism of FD/MAS DOI Creative Commons
Y Wang, Tao Jiang

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 21, 2024

Abstract Background The lack of effective understanding the pain mechanism McCune–Albright syndrome (MAS) has made treatment in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address dilemma. Objective This paper summarizes novel mechanisms, targets, treatments that may produce MAS fibrous dysplasia (polyfibrous dysplasia, or FD). Methods We conducted systematic search PubMed database, Web Science, China Knowledge Network (CNKI) with following keywords: “McCune–Albright (MAS); polyfibrous (FD); bone pain; remodeling; G protein coupled receptors; GDNF family purinergic receptors glycogen synthase kinase”, as well other keywords were systematically searched. Papers published between January 2018 May 2023 selected for finding. Initial screening was performed by reading titles abstracts, available literature screened against inclusion exclusion criteria. Results In review, we analyzed cutting-edge advances disease, synthesized findings, discussed differences. With regard complete mechanistic condition FD/MAS, particular, collated findings on pathways, neurotrophic factor receptors, interferon-stimulating factors, potassium channels, kinases, corresponding hormonal modulation their respective strengths weaknesses. Conclusion focuses basic research explore FD/MAS mechanisms. New nonneuronal molecular mechanically loaded responsive neurons, potential interventions future directions, large number animal experiments, tissue engineering techniques, trials still verify effectiveness future.

Language: Английский

Citations

0
Epithelial Na + Channels Function as Extracellular Sensors DOI
Ossama B. Kashlan, Xue‐Ping Wang, Shaohu Sheng

et al.

Comprehensive physiology, Journal Year: 2024, Volume and Issue: 14(2), P. 1 - 41

Published: March 29, 2024

Abstract The epithelial Na + channel (ENaC) resides on the apical surfaces of specific epithelia in vertebrates and plays a critical role extracellular fluid homeostasis. Evidence that ENaC senses external environment emerged well before molecular identity was reported three decades ago. This article discusses progress toward elucidating mechanisms through which factors regulate function, highlighting insights gained from structural studies related family members. It also reviews our understanding regulation by physiology disease. After familiarizing reader with channel's physiological roles structure, we describe central protein allostery ENaC's sensitivity to environment. We then discuss each directly channel: proteases, cations anions, shear stress, other regulators particular compartments. For regulator, initial observations led discovery, investigating mechanism, pathophysiological implications regulation. © 2024 American Physiological Society. Compr Physiol 14:5407‐5447, 2024.

Language: Английский

Citations

0