Anticancer Therapies Based on Oxidative Damage: Lycium barbarum Inhibits the Proliferation of MCF-7 Cells by Activating Pyroptosis through Endoplasmic Reticulum Stress

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 708 - 708

Published: June 11, 2024

Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also an important source of bioactive compounds such polysaccharides, carotenoids, phenolics, various other non-nutritive compounds. These constituents give it a multitude health benefits, including antioxidant, anti-inflammatory, anticancer properties. However, the precise biochemical mechanisms responsible effects remain unclear, comprehensive composition extracts often insufficiently explored. This study aimed to investigate pathways modulated in breast cancer cells by ethanolic extract barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed antitumoral LBE on different cell lines. investigation revealed that exhibited cytotoxic effects, inducing pro-oxidant effect triggered pyroptosis activation through endoplasmic reticulum (ER) stress subsequent P-IRE1α/XBP1/NLRP3 axis MCF-7 cells. In addition, did display cytotoxicity toward healthy human demonstrated antioxidant neutralizing ROS generated doxorubicin. findings underscore potential promising natural therapy.

Language: Английский

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Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 24, 2024

Objective Selenium is an essential micronutrient and a type of dietary antioxidant. This study aimed to investigate the associations selenium intake with risk human chronic disease [cardiovascular (CVD), diabetes mellitus (DM), cancer] mortality among US general adults. Methods The demographic data in this were collected from National Health Nutrition Examination Survey (NHANES) 2007 2018. Death outcomes determined by associating Index (NDI) records as December 31, 2019. Logistic regression analyses used relationship CVD, DM, cancer. effect on all-cause disease-specific was estimated restricted cubic spline (RCS) curves based univariate multivariate Cox proportional hazard models. Results Among 25,801 participants, divided into quintiles (Q1–Q5). After covariate adjustment, results showed that participants higher (Q4 Q5) tended have low CVD (OR = 0.97, 95% CI: 0.96, 0.99; OR 0.98, 1.00, respectively). Moreover, RCS significant nonlinear association between (with HR 0.82, 0.68, 0.99) DM-specific lowest 0.30; CI, 0.12–0.75). Furthermore, we conducted subgroup analysis found negative correlation highest quartile aged 50 above (HR 0.75, 0.60–0.93, p 0.009). Conclusion Our indicated moderate supplement decreased displayed trend In addition, older may benefit intake. However, these findings still need be confirmed through further mechanism exploration.

Language: Английский

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Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5305 - 5305

Published: July 10, 2023

Breast cancer (BC) is a complex and heterogeneous disease, oxidative stress hallmark of BC. Oxidative characterized by an imbalance between the production reactive oxygen species (ROS) antioxidant defense mechanisms. ROS has been implicated in BC development progression inducing DNA damage, inflammation, angiogenesis. Antioxidants have shown to scavenge protect cells from thereby regulating signaling pathways involved cell growth, survival, death. Plants contain antioxidants like ascorbic acid, tocopherols, carotenoids, flavonoids, which found regulate PCD Combining different promise enhancing effectiveness treatment. Antioxidant nanoparticles, when loaded with antioxidants, can effectively target breast enhance their cellular uptake. Notably, these nanoparticles promising results sensitizing chemotherapy, even cases where resistance observed. This review aims explore how nanotechnology modulate cancer. By summarizing current research, it underscores potential properties for treatment

Language: Английский

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Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2748 - 2748

Published: June 14, 2023

Alcoholic liver disease (ALD) and non-alcoholic fatty (NAFLD) are the most common causes of chronic increasingly emerging as a global health problem. Such disorders can lead to damage, resulting in release pro-inflammatory cytokines activation infiltrating immune cells. These some features ALD progression ASH (alcoholic steatohepatitis) NAFLD NASH (non-alcoholic steatohepatitis). Hepatic steatosis, followed by fibrosis, continuous accompanied angiogenesis. This process creates hypoxia, which activates vascular factors, initiating pathological angiogenesis further fibrosis. forms vicious cycle ongoing damage progression. condition exacerbates injury may contribute development comorbidities, such metabolic syndrome well hepatocellular carcinoma. Increasing evidence suggests that anti-angiogenic therapy have beneficial effects on these hepatic their exacerbation. Therefore, there is great interest deepen knowledge molecular mechanisms natural products could both prevent control diseases. In this review, we focus role major compounds against steatohepatitis determine potential therapeutic benefits treatment inflammation caused an imbalanced diet.

Language: Английский

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Breath of Danger: Unveiling PM2.5’s Stealthy Impact on Cancer Risks

Anticancer Research, Journal Year: 2024, Volume and Issue: 44(4), P. 1365 - 1368

Published: March 27, 2024

This article explores the intricate relationship between airborne particulate matter (PM), specifically PM2.5, and its profound impact on human health, emphasising heightened risks of cancer. Examining composition characteristics such as particle size surface area, reveals ability to induce inflammatory injury oxidative damage. The carcinogenic potential extends beyond respiratory implications, affecting various organs, including digestive tract, breast, prostate. In addition genotoxic effects attached polycyclic aromatic hydrocarbons are recognized be endocrine-disrupting chemicals with specific implications for breast prostate Long-term exposure PM2.5 is associated increased cancer mortality, identified different types. linear correlation risk concentration calls a re-evaluation permissible emission levels. concludes by proposing mitigating strategies individuals exposed elevated PM2.5. It suggests antioxidant-rich diets supplements, exploring inhalation-based antioxidant administration protective measures.

Language: Английский

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The Bioactivity and Phytochemicals of Muscari comosum (Leopoldia comosa), a Plant of Multiple Pharmacological Activities

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2592 - 2592

Published: Feb. 23, 2024

Leopoldia comosa (LC), popularly known as Muscari comosum, spontaneously grows in the Mediterranean region and its bulbs are used a vegetable. Traditionally, they also to treat various diseases conditions, which has inspired study of pharmacological activities different parts LC. These studies revealed numerous biological properties LC including antioxidant, anti-inflammatory, anti-diabetes, anti-obesity, anti-cancer, anti-Alzheimer's disease, antibacterial, immune stimulant. High antioxidant activity compared other non-cultivated plants, potential role reported make an excellent candidate be developed plant against important associated diseases. The presence diverse class phytochemicals (n = 85), especially flavonoids homoisoflavones, LC, imparts significance nutraceutical candidature plant. However, limited animal lack directional approach have further design effective clinical for development current is first attempt comprehensively compile information regarding emphasize targets/markers targeted by activities, highlight gaps propose possible bridges therapeutic and/or supplement

Language: Английский

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Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential

Bioorganic & Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 92, P. 117439 - 117439

Published: Aug. 9, 2023

Language: Английский

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Farnesol Inhibits Cell Viability and Activates Apoptosis in Glioma C6 Cells via Downregulating Phosphoinositide 3-kinase (PI3K)/Protein Kinase B (AKT)/Mammalian Target of Rapamycin (mTOR) Pathway

Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Background Gliomas are the most aggressive and devastating brain tumors, with a poor prognosis due to their complex etiology, diverse clinical manifestations, limited efficacy of existing treatment methods. Purpose The present work was conducted understand anticancer activities farnesol against glioma C6 cells. Methods effects on in vitro free radical scavenging were evaluated at various dosages (1–100 µM). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test used assess influence growth cells nonmalignant Vero apoptotic levels investigated using 4′,6-diamidino-2-phenylindole (DAPI) dual staining assays. oxidative stress markers, inflammatory biomarkers, protein levels, phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR) pathway proteins assessed respective kits. Results results assays proved antioxidant properties farnesol. MTT assay findings demonstrated significant reduction cell viability following fluorescent onset apoptosis farnesol-treated Furthermore, effectively increased stress, reduced marker PI3K, AKT, mTOR expression also successfully downregulated by Conclusion current demonstrate that suppresses triggers Thus, it has capacity be an effective agent treat glioma. Nonetheless, additional is still necessary future determine specific molecular mechanisms involved farnesol-induced

Language: Английский

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The protection of bisphenol A-modulated miRNAs and targets by natural products

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109299 - 109299

Published: Jan. 1, 2025

Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties considered to be able protect toxicity. Although BPA-modulated targets miRNAs have been individually reported, their connections natural were rarely organized. With help of protein-protein interaction database (STRING), relationship between individual was interconnected provide systemic view. In this review, BPA-downregulated -upregulated classified, interactive network innovatively analyzed using bioinformatic (STRING). also retrieved ingeniously connected targets. Moreover, novel connection BPA-countering integrated into All these targets-associated and/or incorporated STRING network, providing relationships. Overall, target-miRNA-protecting product axis constructed, straightforward direction for effects products.

Language: Английский

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Metabolomics insights into the protective molecular mechanism of Vaccinium myrtillus against oxidative stress in intestinal cells

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

Abstract Blueberry ( Vaccinium myrtillus L. ) is a rich source of secondary metabolites known for their potent antioxidant, anti-inflammatory, and cytoprotective properties. These compounds are essential in neutralizing reactive oxygen species (ROS), which implicated oxidative stress-related diseases. In this study, we induced stress IEC-6 small intestine cells using hydrogen peroxide (H 2 O ), creating cellular model to investigate the biochemical response. The obtained results showed that blueberry extract (BLUBE) significantly exhibited strong antioxidant capacity, as evidenced by DPPH, FRAP ABTS vitro tests. Additionally, BLUBE effectively inhibited release enhanced response, indicated improved wound healing clonogenic potential reduction fibers rearrangement apoptosis. Metabolomic analysis, specifically High-Resolution Mass Spectrometry (HR-MS), was employed elucidate metabolic alterations associated with protective activity against cells. Chemometric approaches were applied preprocess data, explore variability, identify systematic biases, ensuring removal batch effects other experimental artifacts. A Partial Least Squares Discriminant Analysis classification confirmed clear group stratifications high accuracy (98.75 ± 2.31%), sensitivity, specificity, aiding identification significant pathway enrichment analysis. Key pathways, including sphingolipid metabolism, taurine hypotaurine glycerophospholipid cysteine methionine modulated, supporting basis BLUBE’s effects. fact, able partially reverse downregulation these reducing promoting cell survival. This study highlights power HR-MS-based metabolomics uncovering mechanisms nutraceuticals emphasizes agent It also underscores growing significance food pharmaceutical industries.

Language: Английский

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