Nigerian Journal of Physiological Sciences,
Journal Year:
2023,
Volume and Issue:
38(1), P. 79 - 89
Published: June 30, 2023
Ulcerative
colitis
(UC)
is
a
chronic
disorder
that
involves
inflammation.
This
study
was
carried
out
to
examine
the
anti-inflammatory
effect
of
methanol
extract
Brideliaferrugineastem
barkinAcetic
acid-induced
ulcerative
inmaleWistarrats.
Twenty-four
rats
were
randomly
divided
into
6
groups
4
animals
each,
thereafter
induced
by
intrarectal
administration
of4%
(v/v)Aceticacidin
all
except
group
1,
which
received
distilled
water.
For
post-colitis
induction
treatment
2
water,
3,
and
5
orally
administeredthe
at
doses
100mg/kg,
200mg/kg
400mg/kg,
respectively
while
sulfasalazine
500mg/kg
orally.Post
induction,
lasted
for
7
days
end
experiment,
colon
samples
collected
estimation
antioxidant,
inflammatory
histological
parameters.
Molecular
docking
also
gain
more
insights
about
promising
compounds
earlier
identified
in
extract.Results
revealed
significantly
(p<0.05)
attenuated
increased
MDA,
nitrite,TNF-α
IL-6
levels.
Activities
SOD,
CAT,
MPO
GSH
levelswere
also,
increased.
Furthermore,
molecular
α-amyrin
may
have
contributed
activity
because
its
remarkable
binding
affinity
IL-6,
iNOS,
IL1-β,TNF-α
COX-2
relative
prednisolone
celecoxib.
suggests
acetic
via
antioxidative
mechanisms.
.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 908 - 908
Published: Jan. 17, 2025
The
objective
of
the
present
study
was
to
compare
recent
methods
for
characterizing
cell
modifications.
We
studied
effect
extracellular
reduced
glutathione
(GSH)
on
an
olfactory
neuroblast
line
(13s24).
Three
were
used
monitor,
in
label-free,
noninvasive
real-time
experiments,
surface
occupancy
by
measuring
impedance
(xCELLigence),
behavior
(HoloMonitor
cytometry),
ultrastructure
refractive
index
(3D
Nanolive
microscopy).
Reduced
dose-dependently
increased
volume
and
motility
decreased
adhesion.
Cell
sorting
analyses
revealed
that
after
short-term
exposure
(6
h),
GSH
F-actin
polymerization
glycoproteins
leading
adhesion
strength
loss.
Results
support
hypothesis
excreted
could
modulate
disulfide
bound-dependent
integrin
conformations
involved
neurogenesis
and/or
neuronal
plasticity.
This
is
first
evidence
a
causal
link
between
changes
required
division,
migration,
differentiation.
show
importance
analysis
methods,
without
labelling,
responses
under
culture
conditions.
findings
highlight
important
criteria
choice
beyond
parameters
studied,
such
as
preparation
time,
plate
filling
number
cells
friendly
use
devices,
complexity
data
processing.
Translational Vision Science & Technology,
Journal Year:
2025,
Volume and Issue:
14(2), P. 19 - 19
Published: Feb. 14, 2025
To
investigate
the
relationship
between
serum
biochemical
variables
and
corneal
biomechanics
in
healthy
young
adults.
A
total
of
1645
university
students
were
included.
Every
student
underwent
an
ophthalmologic
examination
by
Corvis
ST
to
measure
a
blood
evaluate
alanine
aminotransferase
(ALT),
aspartate
(AST),
urea,
creatinine,
uric
acid
(UA)
levels.
Canonical
correlation
analysis
(CCA)
was
conducted
assess
their
relationship.
significant
found
both
men
women.
For
men,
canonical
identified
association
time
first
applanation
(A1t),
second
(A2t),
highest
concavity
(HC-t),
deflection
amplitude
(HC-DeflA),
biomechanically
corrected
intraocular
pressure
(bIOP)
with
ALT,
AST,
UA
(r
=
0.235,
P
0.03).
women,
A1t,
A2t,
bIOP
ALT
0.187,
<
0.01).
Elevated
levels
associated
softer
corneas
greater
elasticity
viscidity.
The
study
provides
novel
evidence
for
ocular
changes.
These
findings
may
help
clinicians
perform
adequate
preoperative
evaluations
when
performing
surgery
on
patients
liver
or
kidney
disorders,
as
well
helping
public
health
practitioners
understand
changes
people.
Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(5)
Published: May 1, 2025
ABSTRACT
Astrocytes
have
essential
functions
in
the
brain
as
partners
of
neurons
many
metabolic
and
homeostatic
processes.
The
metabolism
tripeptide
GSH
(γ‐L‐glutamyl‐L‐cysteinyl‐glycine)
is
an
important
example
a
interaction
between
astrocytes
neurons.
present
cells
millimolar
concentrations
has
antioxidant
substrate
for
detoxification
reactions.
A
high
content
protects
against
oxidative
stress
toxins
therefore
beneficial
astrocytic
self‐defense
that
helps
to
maintain
will
enable
eliminate
potential
before
they
may
reach
other
cells.
In
addition,
provide
with
amino
acids
required
synthesis
process
involves
export
from
by
multidrug
resistance
protein
1,
extracellular
processing
via
γ‐glutamyl
transpeptidase
generate
dipeptide
cysteinyl‐glycine,
cleavage
this
neuronal
ectopeptidase
aminopeptidase
N.
As
strongly
depends
on
cytosolic
concentration,
also
facilitate
release
thereby
supply
precursors
neighboring
article,
we
give
overview
current
knowledge
astrocytes,
address
how
can
help
functions,
discuss
open
questions
future
perspectives
research
healthy
diseased
brain.
image
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 25, 2024
Sepsis
remains
a
formidable
challenge
in
healthcare,
characterized
by
dysregulated
host
response
to
infection,
leading
organ
dysfunction
and
high
mortality
rates.
Glutathione,
critical
antioxidant
regulator
of
cellular
redox
balance,
has
emerged
as
key
player
the
pathophysiology
sepsis.
This
comprehensive
review
explores
multifaceted
role
glutathione
sepsis,
focusing
on
its
involvement
oxidative
stress,
immune
modulation,
dysfunction.
Glutathione
depletion
exacerbates
damage
inflammatory
responses,
thereby
contributing
progression
Understanding
intricate
mechanisms
underlying
dysregulation
sepsis
offers
potential
therapeutic
avenues,
with
strategies
targeting
pathways
showing
promise
mitigating
septic
complications.
However,
further
research
is
needed
optimize
approaches
identify
biomarkers
for
patient
stratification.
Overall,
this
underscores
importance
elucidating
glutathione's
management
improve
clinical
outcomes
reduce
global
burden
life-threatening
condition.
