Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Language: Английский

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The role of melatonin in ensuring male reproductive health

Russian Journal of Human Reproduction, Journal Year: 2023, Volume and Issue: 29(5), P. 111 - 111

Published: Jan. 1, 2023

Language: Английский

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Spermatogenesis recovery treatment in less than four months from zero to almost 16 million sperms per milliliter after several cycles of steroids in 44‐year‐old healthy man

Clinical Case Reports, Journal Year: 2023, Volume and Issue: 11(11)

Published: Nov. 1, 2023

Key Clinical Message The most common external factors that men can have influence on, and improve its own spermatogenesis, are related to lifestyle, habits, stress level, sport activities, nutrition quality, medications. Steroids became one of the key issues in young during reproductive stage life. More more teenagers who not even developed yet naturally start using supplements very early build up body strengths muscles shortest possible time. In this report is presented case 44‐year‐old (November 2022), healthy, sporty man, 1–2 times per year on steroid cycles since he turned 40th. He had intention become a father; however after 6 months last cycle, sperm count was zero. This will show what needed successfully done within less than 4 steroids administration moment when reached almost 16 million sperms milliliter. However, it has be clear unique additional tests would bigger population confirm fast post recovery healthy subjects, approach from manuscript.

Language: Английский

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Phage Display Identified Novel Leydig Cell Homing Peptides for Testicular Targeting

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(3), P. 809 - 822

Published: Feb. 5, 2024

Conventional drug delivery methods to treat testicular disorders face various challenges, which could be circumvented by using targeted delivery. Testicular cell targeting ligands, such as Leydig homing peptides, would an excellent choice achieve the of drugs testis. In this study, peptides (LCHPs), LCHP1 and LCHP2, were identified via in vitro, followed vivo biopanning a phage display peptide library next-generation sequencing. Both LCHPs validated vitro for their specific testis potential. Furthermore, molecular targets LCHP2 affinity purification mass spectrometry (APMS). The are able specifically target cells undergo internalization well at level, hence providing opportunity utilized potential ligand

Language: Английский

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Natural Biomolecules, Plant Extracts and Molecular Hydrogen—New Antioxidant Alternatives in the Management of Male Infertility

Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 359 - 384

Published: Jan. 1, 2024

Language: Английский

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