Journal of Asia-Pacific Entomology, Journal Year: 2024, Volume and Issue: unknown, P. 102351 - 102351
Published: Nov. 1, 2024
Language: Английский
International Journal of Medical Arts, Journal Year: 2024, Volume and Issue: 0(0), P. 0 - 0
Published: July 9, 2024
Background: Diabetes mellitus and other chronic medical conditions are associated with ageing. Sarcopenia is also affected elderly populations. The role of inflammation oxidative stress in both poorly investigated.The aim the work: current work was designed to examine possible association sarcopenia diabetes subjects. Patients Methods: Eighty patients older than 65 years age were included work. They categorized into two equal groups; first for second diabetics without sarcopenia. All clinically evaluated, addition laboratory workup check oxidant-antioxidant system besides some inflammatory markers.Results: No significant differences recognized regarding patient demographics, comorbid or duration diabetes. There reduction BMI, hip circumference, skeletal muscle mass gait speed sarcopenic non-sarcopenic group [25.51 ± 0.67, 98.15 3.97, 7.07 0.83 0.68 0.11 vs. 27.07 1.31, 105.53 4.59, 9.44 1.01 0.98 0.12, successively]. increase CRP, xanthine oxidase, groups [5.15 0.72, 0.532 0.109 3.03 0.78, 0.344 0.063, respectively]. However, plasma glutathione significantly reduced [0.190±0.057 0.233±0.047, Finally, glutathione, BMI absolute development sarcopenia.Conclusion: Oxidative disturbance systems seems play a crucial
Language: Английский
Citations
0
Journal of Integrative Agriculture, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
0
Egyptian Journal of Medical Human Genetics, Journal Year: 2024, Volume and Issue: 25(1)
Published: Oct. 12, 2024
Abstract Background Endometriosis is a common cause of endometrial-type mucosa outside the uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain intercourse and infertility. However, early diagnosis endometriosis still restricted. The purpose this investigation to identify validate key biomarkers endometriosis. Methods Next-generation sequencing dataset GSE243039 was obtained from Gene Expression Omnibus database, differentially expressed genes (DEGs) between normal control samples were identified. After screening DEGs, gene ontology (GO) REACTOME pathway enrichment analyses performed. Furthermore, protein–protein interaction (PPI) network constructed modules analyzed using Human Integrated Protein–Protein Interaction rEference database Cytoscape software, hub Subsequently, miRNAs genes, TFs miRNet NetworkAnalyst tool, possible predicted. Finally, receiver operating characteristic curve analysis used genes. Results A total 958 including 479 upregulated downregulated screened samples. GO DEGs showed that they mainly involved in multicellular organismal process, developmental signaling by GPCR muscle contraction. Further PPI identified 10 vcam1, snca, prkcb, adrb2, foxq1, mdfi, actbl2, prkd1, dapk1 actc1. Possible target miRNAs, hsa-mir-3143 hsa-mir-2110, TFs, tcf3 (transcription factor 3) clock (clock circadian regulator), predicted constructing miRNA-hub regulatory TF-hub network. Conclusions This bioinformatics techniques explore potential novel biomarkers. These might provide new ideas methods for diagnosis, treatment monitoring
Language: Английский
Citations
0
Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5165 - 5177
Published: Oct. 1, 2024
Gastric cancer (GC) has a high incidence and mortality rate with poor prognosis, so it is crucial to search for new biomarkers. The role of NETosis, newly identified type programmed cell death, in GC its underlying mechanisms have yet be explored still require thorough investigation. Our research seeks enhance our comprehension NETosis may offer novel approaches treating GC.
Language: Английский
Citations
0
Journal of Asia-Pacific Entomology, Journal Year: 2024, Volume and Issue: unknown, P. 102351 - 102351
Published: Nov. 1, 2024
Language: Английский
Citations
0