Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011–2018

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 464, P. 133005 - 133005

Published: Nov. 16, 2023

Language: Английский

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Effects of Physical Activity Program on Body Composition, Physical Performance, and Neuromuscular Strategies during Walking in Older Adults with Sarcopenic Obesity: Randomized Controlled Trial

Healthcare, Journal Year: 2023, Volume and Issue: 11(16), P. 2294 - 2294

Published: Aug. 14, 2023

The potential impact of a specific physical activity program on biomechanical gait parameters and neuromuscular strategies around the ankle joint in older adults with sarcopenic obesity (SO) remains largely unexplored. objective this study was to investigate effectiveness 24-week posture, strengthening, motricity (PSM) improving SO. 40 participants were randomly assigned either trained group (TG) control (CG). Only TG received PSM program. Standardized evaluations performed before after intervention, including walking tests an instrumented analysis treadmill evaluate EMG muscles. After program, exhibited increase comfortable speed (+80%, p < 0.001) step length (+38%, 0.05). Moreover, demonstrated reduction CoP velocity (-26%, 0.01). These modifications associated decreased muscle during different phases (p effectively improved capacities Notably, these results shed light remarkable trainability SO, despite adverse effects aging obesity.

Language: Английский

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Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 499 - 499

Published: Jan. 29, 2025

A wide range of factors contribute to the overlap hyperglycemia—acute or chronic—and sarcopenia, as well their associated adverse consequences, which can lead impaired physical function, reduced quality life, and increased mortality risk. These include malnutrition (both overnutrition undernutrition) low levels activity. Hyperglycemia sarcopenia are interconnected through a vicious cycle events that mutually reinforce worsen each other. To explore this association, our review compiles evidence on: (i) impact hyperglycemia on motor muscle with focus mechanisms underlying biochemical changes in muscles individuals at risk diabetes sarcopenia; (ii) importance clinical assessment control under hyperglycemic conditions; (iii) potential benefits medical nutrition therapy activity muscle-targeted treatments for population. Based reviewed evidence, we conclude regular intake key functional nutrients, together structured supervised resistance and/or aerobic activity, help maintain euglycemia improve status all patients sarcopenia.

Language: Английский

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Relationship between masticatory function and sarcopenic obesity in community-dwelling older adults aged 75 or older: a cross-sectional study

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 22, 2025

The relationship between sarcopenic obesity and masticatory function is poorly understood. This study aims to explore this association in community-dwelling individuals aged 75 years or older. analyzed data from 236 adults Masticatory was assessed using spectrophotometric measurement of gum color differences before after chewing color-changeable (ΔE*ab). Participants were categorized into tertiles based on their ΔE*ab values. defined as low, intermediate, high. Sarcopenic the Consensus statement Japanese Working Group Obesity. Bayesian multinomial logistic regression employed examine obesity. prevalence rates for obesity, sarcopenia, 15.3%, 24.2%, 9.7%, respectively. After adjusting covariates, participants with high had a significantly lower posterior estimate (posterior estimate: −1.83 [95% credible interval: −3.66, −0.22]) sarcopenia −1.97 −3.37, −0.72]) compared low function. However, no significant associations observed These findings suggest that associated older adults.

Language: Английский

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A Combination of Resveratrol and Quercetin Prevents Sarcopenic Obesity: Its Role as a Signaling Inhibitor of Myostatin/ActRIIA and ActRIIB/Smad and as an Enhancer of Insulin Actions

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4952 - 4952

Published: May 21, 2025

Sarcopenic obesity (SO), characterized by an excess of fat and a decrease in muscle strength or mass, is global public health concern linked to metabolic conditions such as syndrome (MetS). Different mechanisms contribute SO, inflammation, fatty acid infiltration, insulin resistance (IR). Recently, myostatin (MYOST), inhibitory factor for skeletal tissue, was proposed aimed compound the treatment muscular imbalance mass MetS. On other hand, therapy with natural compounds resveratrol (R) quercetin (Q) effective MetS, but its effect on MYOST pathway has been poorly explored. The control group received water, MetS 30% commercial sugar drinking water 6 months. Polyphenol mix (R at dose 50 mg/kg/day Q 0.95 mg/kg/day) administered 1 month. rats present SO increase expression MYOST/ActRIIA ActRIIB (p < 0.0001). R+Q prevented lowering receptors increased Smad 7 Moreover, polyphenol reverted IR increasing Akt phosphorylation, leading mass. It decreased lipid stores, restored glycogen accumulation, myosin results this work indicate that supplementation could be promising therapeutic agent prevent sarcopenia derived from alterations.

Language: Английский

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Age-Related Changes in Insulin Resistance and Muscle Mass: Clinical Implications in Obese Older Adults

Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1648 - 1648

Published: Oct. 8, 2024

The older segment of the global population is increasing at a rapid pace. Advancements in public health and modern medicine lengthened life expectancy reduced burden disease communities worldwide. Concurrent with this demographic change rise overweight people obesity, which evident all age groups. There also an aging-related reduction muscle mass function, or sarcopenia, that exacerbated by sedentary lifestyle poor nutrition. coexistence loss elevated body index, termed “sarcopenic obesity”, has particularly deleterious consequences individuals. Worsening insulin resistance proinflammatory state operate pathophysiologic level lead to adverse outcomes such as proclivity cardiovascular disease, type 2 diabetes, even cognitive dysfunction. Although concept sarcopenic obesity construct being increasingly recognized, clearer understanding warranted order define its components impact. Research needed molecular-cellular tie together derangements action, cytokines, myokines, endothelial dysfunction clinical outcomes. Lifestyle modifications well targeted nonpharmacologic approaches, supplements antioxidants, appear have promising role reducing chronic emerging disorder. Breakthroughs drug therapies retard reverse underlying dynamics sarcopenia persons are actively explored.

Language: Английский

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Association between urinary volatile organic compound metabolites and sarcopenia in the US general population: a cross-sectional NHANES study from 2011 to 2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 28, 2025

Volatile organic compound (VOC) is a prevalent form of pollutant that has been linked to various human ailments, yet their connection sarcopenia remains uncertain. This study seeks examine the potential association between exposure mixtures metabolites volatile compounds (mVOCs) and sarcopenia, while also investigating mediating effects oxidative stress inflammation. Data from 2011-2018 National Health Nutrition Examination Survey (NHANES) were utilized for analysis relationship mVOCs through logistic regression. The least absolute shrinkage selection operator (LASSO) regression model was employed identify key mVOCs, quantile-g computation (qgcomp) bayesian kernel machine (BKMR) models mVOC sarcopenia. Potential factors explored analysis. Of 2908 participants included in study, 246 individuals (8.5%) found have Logistic revealed five urinary VOC positively correlated with an increased risk identified LASSO method further analyzed using qgcomp, which showed 47% average increase when exposed mixture (OR = 1.47, 95% CI 1.14-1.91). Four components (DHBMA, 3HPMA, ATCA 3,4MHA) largest weight. BKMR results confirm this joint association. Furthermore, Mediation inflammation mediate In conclusion, our provides evidence suggesting heightened potentially serving as mediators relationship. It recommended additional cohort studies be conducted validate these findings.

Language: Английский

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Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 13418 - 13430

Published: Nov. 24, 2024

Obesity causes fat accumulation, and sarcopenia loss of muscle mass strength; together, they worsen insulin resistance accelerate decline, creating a harmful cycle. Some supplements, along with physical exercise, could be remedies for sarcopenic obesity (SO). In this review, we aim to draw comparison between supplements studied in experimental research those evaluated clinical studies SO. studies, Sea Buckthorn—in forms such as oil, freeze-dried powder or pomace—has been shown enhance cell growth, improve gut microbiota, provide hypoglycemic benefits increase by promoting protein synthesis. Increased consumption Omega-3 fatty acids may play protective role against SO women. Melatonin positively impact reducing oxidative stress. Elevated irisin levels, observed vitamin D supplementation, prevent wasting gain improving sensitivity inflammation. There have many highlighting the potential preventing age related sarcopenia; however, effect supplementation is under-researched appears less promising. Future trials using natural hold promise, these multiple beneficial components that work synergistically treat

Language: Английский

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PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28936 - e28936

Published: April 1, 2024

Obesity is currently one of the most alarming pathological conditions due to progressive increase in its prevalence. In last decade, it has been associated with fine particulate matter suspended air (PM2.5). The purpose this study was explore mechanistic interaction PM2.5 a high-fat diet (HFD) through differential regulation transcriptional signatures, aiming identify association these particles metabolically abnormal obesity. research design observational, using bioinformatic methods and an explanatory approach based on Rothman's causal model. We propose three new signatures murine adipose tissue. sum differences between group exposed HFD PM2.5, compared control group, were 0.851, 0.265, −0.047 (p > 0.05). increased body mass by 20% two positive biomarkers metabolic impact. maintained similar weight but exhibited biomarkers. Enriched biological pathways < 0.05) included PPAR signaling, small molecule transport, adipogenesis genes, cytokine-cytokine receptor interaction, HIF-1 signaling. Transcriptional predictions revealed CpG islands common transcription factors. signatures: FAT-PM2.5-CEJUS, FAT-PM2.5-UP, FAT-PM2.5-DN, whose profile adipocytes statistically dietary intake exposure mice; suggesting both However, HFD-exposed murines developed moderate obesity, PM2.5-exposed severe metabolism without Therefore, terms, concluded that sufficient cause development component These would be integrated into systemic process induce trans, activating obesogenic pathways, restricting lipid mobilization decreasing adaptive thermogenesis angiogenesis, altering vascular tone thus inducing

Language: Английский

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Association between sarcopenic obesity and osteoarthritis: The potential mediating role of insulin resistance

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 197, P. 112611 - 112611

Published: Oct. 21, 2024

Sarcopenic obesity (SO) and osteoarthritis (OA) are highly prevalent musculoskeletal conditions that significantly impair health-related quality of life.

Language: Английский

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