PubMed,
Journal Year:
2023,
Volume and Issue:
22, P. 1280 - 1310
Published: Jan. 1, 2023
It
is
now
an
accepted
principle
that
epigenetic
alterations
cause
cellular
dyshomeostasis
and
functional
changes,
both
of
which
are
essential
for
the
initiation
completion
tumor
cycle.
Oral
carcinogenesis
no
exception
in
this
regard,
as
most
tumors
different
subsites
oral
cavity
arise
from
cross-reaction
between
(epi)genetic
inheritance
huge
challenge
environmental
stressors.
Currently,
biochemical
machinery
put
at
service
program,
halting
cell
cycle,
triggering
uncontrolled
proliferation,
driving
angiogenesis
resistance
to
apoptosis,
until
archetypes
phenotype
reached.
Melatonin
has
ability
dynamically
affect
code.
become
melatonin
can
reverse
aberrations
present
other
cancers,
suggesting
possibility
enhancing
oncostatic
capacity
standard
multimodal
treatments
by
incorporating
indolamine
adjuvant.
First
steps
direction
confirm
potential
a
countermeasure
mitigate
detrimental
side
effects
conventional
first-line
radiochemotherapy.
This
single
effect
could
produce
synergies
extraordinary
clinical
importance,
allowing
doses
be
increased
not
interrupted,
ultimately
improving
patients'
quality
life
prognosis.
Motivated
urgency
medical
management
cancer,
many
authors
advocate
moving
Journal of Neuroendocrinology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
Abstract
Illuminated
nights
reduce
melatonin
peak
and
disrupt
sleep.
Using
this
as
the
basis
of
present
experimental
paradigm,
we
investigated
whether
nocturnal
levels
were
crucial
for
sleep
regulation
in
a
diurnal
vertebrate.
Acclimated
Indian
house
crows
(
Corvus
splendens
)
randomly
segregated
into
three
groups
12
each.
For
next
10
days,
one
group
was
maintained
on
L:12
D,
before
(LD
control);
other
two
groups,
absolute
darkness
replaced
with
dim
light
at
night
(dLAN;
L
=
~150
lux,
D
~6
lux).
Under
dLAN,
half
an
hour
off
time,
LD
control
dLAN
received
intraperitoneally
200
μL
vehicle
(0.75%
physiological
saline),
while
similar
but
containing
dose
50
μg
bird
−1
day
.
exogenous
elevated
AANAT
mRNA
plasma
induced
changes
expressions
clock
genes
PER2
,
CRY1
BMAL1
NPAS2
REVERB
pineal
gland
hypothalamus,
encoding
receptors
MEL1a
MEL1b
epigenetic
modifiers
HAT1
HDAC2
HDAC4
DNMT3a
hypothalamus.
Elevated
bettered
positive
effects
hypothalamic
expression
associated
(cytokine
pathway:
TLR4
TNFα
IL‐1β
NOS1
;
calcium
CAMK2
SIK3
awake
ACHM3
EGR1
HOMER1a
OREXIN
states,
neurogenesis
synaptic
plasticity
BDNF
CREB
).
These
suggested
role
mitigation
dLAN‐induced
disruption.
Nocturnal
are
component
regulatory
transcriptional
pathways
underlying
daily
wake–sleep
pattern,
far‐reaching
implications
sleep‐related
issues
species
including
perhaps
humans
inhabiting
over‐lit
environment
pervasive
pollution.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13619 - 13619
Published: Sept. 3, 2023
There
have
been
concerns
about
the
potential
health
risks
posed
by
microplastics
(MP).
The
detection
of
MP
in
a
variety
food
products
revealed
that
humans
are
ingesting
MP.
Nevertheless,
there
is
paucity
data
their
impacts,
as
well
uptake,
on
intestinal
barrier
integrity.
This
study
examined
toxic
effects
oral
administration
two
doses
polyethylene
(PE-MP)
(3.75
or
15
mg/kg/day
for
5
weeks;
mean
particle
size:
4.0-6.0
µm)
integrity
rats.
Moreover,
effect
melatonin
treatment
with
exposure
was
also
assessed.
PE-MP
histopathological
changes,
Alcian
blue
staining,
Muc2
mRNA,
proinflammatory
cytokines
(IL-1β
and
TNF-α),
cleaved
caspase-3,
tight
junction
proteins
(claudin-1,
myosin
light-chain
kinase
(MLCK),
occludin,
zonula
occludens-1
(ZO-1))
were
Oral
resulted
apparent
jejunal
alterations;
significantly
decreased
mucin
secretion,
ZO-1,
claudin-1
expression;
upregulated
MLCK
IL-1β
concentration,
caspase-3
expression.
Melatonin
reversed
these
altered
parameters
improved
PE-MP-induced
ultrastructure
changes.
highlighted
PE-MP's
protective
melatonin.
Molecular Medicine Reports,
Journal Year:
2023,
Volume and Issue:
28(5)
Published: Sept. 25, 2023
Melatonin
(MLT)
is
a
biologically
active
indoleamine
involved
in
regulating
various
biological
rhythms,
which
deficient
individuals
with
Type
2
diabetes.
The
present
study
examined
the
effects
of
MLT
on
diabetic
neuropathy
(DN).
Diabetic
rats
received
treatment
for
12
weeks,
after
changes
kidney
histology,
oxidative
damage,
mitochondrial
morphology
and
autophagy
were
measured.
glucose
tolerance‑
isoflurane
tolerance‑area
under
curve
(AUC)
values
relative
renal
weight
index
(RI)
diabetes
mellitus
(DM)
group
significantly
higher
compared
those
control
group.
A
significant
increase
malondialdehyde
(MDA)
content,
decreases
activity
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GSH‑Px)
GSH
demonstrated
kidneys
DM
rats.
Histological
staining
rat
tissue
hematoxylin
eosin,
Masson's
trichome
Periodic
acid‑Schiff
glomerular
tubule
lesions,
an
collagen
Protein
expression
levels
LC3II,
P62,
IV
(COL‑IV)
α‑SMA
increased
HG‑induced
NRK‑52E
cells
groups.
Phosphorylation
AMPK
was
reduced,
whereas
phosphorylation
PI3K,
Akt
mTOR
vivo
vitro.
Notably,
reduced
tolerance‑AUC
RI,
decreased
MDA
SOD,
CAT,
GSH‑Px
activity.
Glomerular
lesions
improved,
damage
alleviated
by
treatment.
also
protein
P62
COL‑IV,
increased,
inhibited
AKT
These
results
that
protects
against
DN
cell
injury
through
inhibiting
via
PI3K/AKT/mTOR
signaling
pathway.
Aging Cell,
Journal Year:
2024,
Volume and Issue:
23(8)
Published: May 29, 2024
Abstract
Worldwide
trends
to
delay
childbearing
have
increased
parental
ages
at
birth.
Older
age
may
harm
offspring
health,
but
mechanisms
remain
unclear.
Alterations
in
DNA
methylation
(DNAm)
patterns
could
play
a
role
as
aging
has
been
associated
with
changes
gametes
of
older
individuals.
We
meta‐analyzed
epigenome‐wide
associations
blood
DNAm
over
9500
newborns
and
2000
children
(5–10
years
old)
from
the
Pregnancy
Childhood
Epigenetics
consortium.
In
newborns,
we
identified
33
CpG
sites
13
loci
maternal
(P
FDR
<
0.05).
Eight
these
CpGs
were
located
near/in
MTNR1B
gene,
coding
for
melatonin
receptor.
Regional
analysis
them
together
differentially
methylated
region
consisting
9
in/near
,
which
higher
was
greater
=
6.92
×
10
−8
)
newborns.
childhood
samples,
differences
nominally
significant
(
p
0.05)
retained
same
positive
direction,
suggesting
persistence
associations.
Maternal
also
positively
three
RTEL1‐TNFRSF6B
birth
0.0001).
Of
remaining
persistent
childhood,
cg26709300
YPEL3/BOLA2B
external
data
expression
ITGAL
an
immune
regulator.
While
further
study
is
needed
establish
causality,
particularly
due
small
effect
sizes
observed,
our
results
potentially
support
mechanism
underlying
child
health.
Food Chemistry,
Journal Year:
2024,
Volume and Issue:
458, P. 140172 - 140172
Published: June 28, 2024
Melatonin
(MLT)
is
a
hormone
that
exists
in
all
living
organisms,
including
bacteria,
yeast,
fungi,
animals,
and
plants,
many
of
which
are
ingested
daily
the
diet.
However,
exact
concentrations
melatonin
each
foods
effect
on
health
intake
rich
MLT
not
known.
Therefore,
aim
this
review
was
to
gather
available
information
content
different
evaluate
has
pathologies.
The
amount
may
vary
depending
variety,
origin,
heat
treatment,
processing,
analysis
technique,
among
other
factors.
Dietary
interventions
with
report
benefits,
but
there
no
evidence
partially
responsible
for
clinical
improvement.
it
necessary
more
foods,
as
well
cooking/processing
MLT,
estimate
its
total
typical
diet
better
explore
potential
impact
health.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1688 - 1688
Published: Aug. 29, 2023
The
thyroid
gland
is
the
primary
site
of
sodium/iodide
symporter
(NIS),
an
intrinsic
plasma
membrane
protein
responsible
for
active
uptake
iodine,
which
indispensable
hormone
synthesis.
Since
exposure
to
NIS
inhibitors
can
potentially
have
harmful
effects
on
entire
organism,
it
important
investigate
potential
protective
known
antioxidants,
such
as
melatonin
and
indole-3-propionic
acid
(IPA),
against
pro-oxidative
action
classic
inhibitors.
study
aimed
check
if
what
extent
IPA
interact
with
some
confirmed
regarding
their
oxidative
damage
lipids
in
thyroid.
For
comparison
gland,
typically
present,
liver
tissue-not
possessing
NIS-was
applied
present
study.
Thyroid
homogenates
were
incubated
presence
tested
(i.e.,
NaClO3,
NH4SCN,
KSeCN,
KNO3,
NaF,
KClO4,
BPA)
different
ranges
concentrations
with/without
(5
mM)
or
mM).
malondialdehyde+4-hydroxyalkenals
(MDA
+
4-HDA)
concentration
(LPO
index)
was
measured
spectrophotometrically.
NaClO3
increased
LPO
liver,
but
these
not
prevented
by
either
IPA.
Instead,
NH4SCN
observed
both
tissues
indole
substances.
KSeCN
NaF
only
thyroid,
BPA
did
increase
LPO,
be
due
low
resulting
from
restricted
solubility.
In
conclusion,
caused
inhibitors,
this
indoleamine
shoud
considered
a
agent
when
produced
appropriately
living
organisms
also
exogenous
substance
recommended
individuals
overexposed
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
14(23), P. 4227 - 4239
Published: Nov. 18, 2023
The
neurohormone
melatonin
(MLT)
demonstrates
promising
potential
in
ameliorating
neuropathic
pain
induced
by
paclitaxel
(PTX)
chemotherapy.
However,
little
is
known
about
its
protective
effect
on
dorsal
root
ganglion
(DRG)
neurons
resulting
from
the
chemotherapeutic
drug
PTX.
Here,
PTX-treated
rats
revealed
that
intrathecal
administration
of
MLT
dose-dependently
elevated
hind
paw
withdrawal
thresholds
and
latency,
indicating
significantly
reversed
PTX-induced
pain.
Mechanistically,
analgesic
effects
were
found
to
be
mediated
via
receptor
2
(MT2),
as
pretreatment
with
an
MT2
antagonist
inhibited
these
effects.
Moreover,
injection
pNEK2-dependent
epigenetic
program
All
caused
blocked
receptor-selective
antagonist,
4P-PDOT.
Remarkably,
multiple
administered
during
PTX
treatment
(PTX+MLTs)
exhibited
not
only
rapid
but
also
lasting
reversal
allodynia/hyperalgesia
compared
single-bolus
after
(PTX+MLT).
In
addition,
PTX+MLTs
greater
efficacy
reversing
alterations
pRSK2,
pNEK2,
JMJD3,
H3K27me3,
TRPV1
expression
interaction
DRG
than
PTX+MLT.
These
results
indicated
reduced
incidence
and/or
severity
neuropathy
had
a
better
inhibitory
treatment.
conclusion,
MLT/MT2
therapy
for
painful
chemotherapy
may
more
effective
prevention
or
reduction
maintaining
quality.
