Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
208, P. 107368 - 107368
Published: Aug. 25, 2024
Nutraceuticals
have
been
described
as
phytocomplexes
when
derived
from
foods
of
plant
origin
or
a
pool
secondary
metabolites
animal
origin,
which
are
concentrated
and
administered
in
an
appropriate
form
can
promote
beneficial
health
effects
the
prevention/treatment
diseases.
Considering
that
pharmaceutical
medications
cause
side
effects,
there
is
growing
interest
using
nutraceuticals
adjuvant
therapeutic
tool
for
several
disorders
involving
autonomic
dysfunction,
such
obesity,
atherosclerosis
other
cardiometabolic
This
review
summarizes
discusses
evidence
literature
on
various
control,
addressing
gut
microbiota
modulation,
production
bioactive
compounds,
improvement
physical
chemical
properties
cell
membranes.
Additionally,
safety
prospects
discussed.
Probiotics,
resveratrol,
quercetin,
curcumin,
nitrate,
inositol,
L-carnosine,
n-3
polyunsaturated
fatty
acids
(n-3
PUFAs)
among
most
studied
to
improve
dysfunction
experimental
models
clinical
trials.
Further
human
studies
needed
elucidate
formulated
multitarget
compounds
their
underlying
mechanisms
action,
could
benefit
conditions
dysfunction.
World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
15(11), P. 2189 - 2202
Published: Oct. 16, 2024
Diabetic
retinopathy
(DR),
as
one
of
the
most
common
and
significant
microvascular
complications
diabetes
mellitus
(DM),
continues
to
elude
effective
targeted
treatment
for
vision
loss
despite
ongoing
enrichment
understanding
its
pathogenic
mechanisms
from
perspectives
such
inflammation
oxidative
stress.
Recent
studies
have
indicated
that
characteristic
neuroglial
degeneration
induced
by
DM
occurs
before
onset
apparent
lesions.
In
order
comprehensively
grasp
early-stage
pathological
changes
DR,
retinal
neurovascular
unit
(NVU)
will
become
a
crucial
focal
point
future
research
into
occurrence
progression
DR.
Based
on
existing
evidence,
ferroptosis,
form
cell
death
regulated
processes
like
ferritinophagy
chaperone-mediated
autophagy,
mediates
apoptosis
in
NVU
components,
including
pericytes
ganglion
cells.
Autophagy-dependent
ferroptosis-related
factors,
BECN1
FABP4,
may
serve
both
biomarkers
DR
development
potentially
targets
treatments.
The
aforementioned
findings
present
novel
comprehending
underlying
alterations
open
up
innovative
avenues
investigating
supplementary
therapeutic
strategies.
Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: Sept. 25, 2024
The
Transient
Receptor
Potential
(TRP)
constitutes
a
family
of
channels
subdivided
into
seven
subfamilies:
Ankyrin
(TRPA),
Canonical
(TRPC),
Melastatin
(TRPM),
Mucolipin
(TRPML),
no-mechano-potential
C
(TRPN),
Polycystic
(TRPP),
and
Vanilloid
(TRPV).
Although
they
are
structurally
similar
to
one
another,
the
peculiarities
each
subfamily
key
response
stimuli
signaling
pathway
that
triggers.
TRPs
non-selective
cation
channels,
most
which
permeable
Ca
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8461 - 8461
Published: Aug. 2, 2024
Retinopathy
of
prematurity
(ROP)
is
a
vascular
disorder
affecting
the
retinas
preterm
infants.
This
condition
arises
when
infants
in
incubators
are
exposed
to
high
oxygen
levels,
leading
oxidative
stress,
inflammatory
responses,
and
downregulation
endothelial
growth
factors,
which
causes
loss
retinal
microvascular
capillaries.
Upon
returning
room
air,
upregulation
factors
results
abnormal
cells.
Without
appropriate
intervention,
ROP
can
progress
blindness.
The
prevalence
has
risen,
making
it
significant
cause
childhood
Current
treatments,
such
as
laser
therapy
various
pharmacologic
approaches,
limited
by
their
potential
for
severe
adverse
effects.
Therefore,
deeper
understanding
ROP’s
pathophysiology
development
innovative
treatments
imperative.
Natural
products
from
plants,
fungi,
bacteria,
marine
organisms
have
shown
promise
treating
diseases
gained
attention
research
due
minimal
side
effects
wide-ranging
beneficial
properties.
review
discusses
roles
mechanisms
natural
that
hold
therapeutic
agents
management.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
208, P. 107368 - 107368
Published: Aug. 25, 2024
Nutraceuticals
have
been
described
as
phytocomplexes
when
derived
from
foods
of
plant
origin
or
a
pool
secondary
metabolites
animal
origin,
which
are
concentrated
and
administered
in
an
appropriate
form
can
promote
beneficial
health
effects
the
prevention/treatment
diseases.
Considering
that
pharmaceutical
medications
cause
side
effects,
there
is
growing
interest
using
nutraceuticals
adjuvant
therapeutic
tool
for
several
disorders
involving
autonomic
dysfunction,
such
obesity,
atherosclerosis
other
cardiometabolic
This
review
summarizes
discusses
evidence
literature
on
various
control,
addressing
gut
microbiota
modulation,
production
bioactive
compounds,
improvement
physical
chemical
properties
cell
membranes.
Additionally,
safety
prospects
discussed.
Probiotics,
resveratrol,
quercetin,
curcumin,
nitrate,
inositol,
L-carnosine,
n-3
polyunsaturated
fatty
acids
(n-3
PUFAs)
among
most
studied
to
improve
dysfunction
experimental
models
clinical
trials.
Further
human
studies
needed
elucidate
formulated
multitarget
compounds
their
underlying
mechanisms
action,
could
benefit
conditions
dysfunction.
