Answering the Cell Stress Call: Satellite Non-Coding Transcription as a Response Mechanism DOI Creative Commons
Marisa Fonseca-Carvalho, Gabriela Veríssimo, Mariana Lopes

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 124 - 124

Published: Jan. 17, 2024

Organisms are often subjected to conditions that promote cellular stress. Cell responses stress include the activation of pathways defend against and recover from stress, or initiation programmed cell death eliminate damaged cells. One processes can be triggered under is transcription variation in number copies satellite DNA sequences (satDNA), which involved response mechanisms. Satellite DNAs highly repetitive tandem sequences, mainly located centromeric pericentromeric regions eukaryotic chromosomes, where they form constitutive heterochromatin. non-coding RNAs (satncRNAs) important regulators processes, their deregulation has been associated with disease. Also, these transcripts have stress-response mechanisms varied species. This review intends explore role satncRNAs when cells adverse conditions. Studying satDNA various deepening our understanding how could a key factor uncovering facts about functions sequences.

Language: Английский

Oxidative cell death in cancer: mechanisms and therapeutic opportunities DOI Creative Commons
Xiaoqin An, Wenfeng Yu, Jinbao Liu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 1, 2024

Abstract Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse functions, cell signaling and immune responses. However, a disturbance the balance between production antioxidant defenses can lead to an excessive buildup, causing oxidative stress. This stress damages essential components, lipids, proteins, DNA, potentially culminating death. form of death take various forms, such ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos, oxeiptosis, each displaying distinct genetic, biochemical, characteristics. The investigation holds promise for development pharmacological agents that used prevent tumorigenesis or treat established cancer. Specifically, targeting key SLC7A11, GCLC, GPX4, TXN, TXNRD, represents emerging approach inducing cancer cells. review provides comprehensive summary recent progress, opportunities, challenges therapy.

Language: Английский

Citations

62
Redox changes and cellular senescence in Alzheimer's disease DOI Creative Commons

Nicole Yu,

Mazhar Pasha, John Jia En Chua

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103048 - 103048

Published: Jan. 17, 2024

The redox process and cellular senescence are involved in a range of essential physiological functions. However, they also implicated pathological processes underlying age-related neurodegenerative disorders, including Alzheimer's disease (AD). Elevated levels reactive oxygen species (ROS) generated as result abnormal accumulation beta-amyloid peptide (Aβ), tau protein, heme dyshomeostasis is further aggravated by mitochondria dysfunction endoplasmic reticulum (ER) stress. Excessive ROS damages vital components such proteins, DNA lipids. Such damage eventually leads to impaired neuronal function cell death. Heightened oxidative stress can induce via activation the senescence-associated secretory phenotype exacerbate inflammation tissue dysfunction. In this review, we focus on how changes system contribute AD affected perturbations metabolism mitochondrial function. While potential therapeutic strategies targeting have received some attention, more research necessary bring them into clinical application.

Language: Английский

Citations

26
Recent advances on application of polysaccharides in cosmetics DOI Creative Commons
Qingyuan Wu, Na Cheng,

Danjiao Fang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100004 - 100004

Published: Jan. 30, 2024

Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency. As a highly active substance nature, natural polysaccharides been reported recent years various cosmetic activities such as moisturizing, whitening, anti-aging repairing skin, are becoming hot research topic industry. At present, mechanism of polysaccharide exerting activity has widely studied, but relationship between polysaccharide's chemical structure not effectively analyzed, which leads limitation development. In this review, skin repair was introduced. The potential summarized by analyzing influence physical properties polysaccharides, extraction method, molecular weight, monosaccharide composition, functional group structural modification, etc., laid foundation for analysis improved its value.

Language: Английский

Citations

15
Epigenetic regulations of cellular senescence in osteoporosis DOI
Shaochuan Huo,

Xinzheng Tang,

Weijian Chen

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102235 - 102235

Published: Feb. 16, 2024

Language: Английский

Citations

12
Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 DOI Open Access
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Elena Bustamante Munguira

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3521 - 3521

Published: March 20, 2024

The phrase “Let food be thy medicine…” means that can a form of medicine and food; in other words, the diet we eat have significant impact on our health well-being. Today, this is gaining prominence as more scientific evidence suggests one’s help prevent treat disease. A rich fruits, vegetables, whole grains, lean protein reduce risk heart disease, cancer, diabetes, problems and, hand, processed foods, added sugars, saturated fats increase same diseases. Electrophilic compounds health, they are molecules covalently modify cysteine residues present thiol-rich Keap1 protein. These bind to activate NRF2, which promotes its translocation nucleus binding DNA ARE region, triggering antioxidant response protecting against oxidative stress. include polyphenols flavonoids nucleophilic but converted electrophilic quinones by metabolic enzymes such polyphenol oxidases (PPOs) sulfur foods Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) garlic. This review summarizes current knowledge subject.

Language: Английский

Citations

8
Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration DOI
Riya Thapa, Asif Ahmad Bhat, Moyad Shahwan

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

Citations

8
Integrative transcriptomics and proteomics analysis reveal the protection of Astragaloside IV against myocardial fibrosis by regulating senescence DOI Creative Commons
Lipeng Shi, Jingwei Deng, Jun He

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176632 - 176632

Published: May 6, 2024

Myocardial fibrosis (MF) is a pivotal pathological process implicated in various cardiovascular diseases, particularly heart failure. Astragaloside IV (AS-IV), natural compound derived from Astragalus membranaceus, possesses potent cardioprotective properties. However, the precise molecular mechanisms underlying its anti-MF effects, relation to senescence, remain elusive. Thus, this study aimed investigate therapeutic potential and of AS-IV treating ISO-induced MF mice, employing transcriptomics, proteomics, vitro, vivo experiments. We assessed positive effects on using HE staining, Masson ELISA, immunohistochemical transthoracic echocardiography, transmission electron microscopy, DHE fluorescence staining. Additionally, we elucidated regulatory role through comprehensive transcriptomics proteomics analyses, complemented by Western blotting RT-qPCR validation pertinent pathways. Our findings demonstrated that treatment markedly attenuated myocardial injury oxidative stress, concomitantly inhibiting release SASPs. Furthermore, integrated analyses revealed mechanism was associated with regulating cellular senescence p53 signaling pathway. These results highlight exerts not only stress but also modulating

Language: Английский

Citations

6
The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases DOI Creative Commons
George J. Kontoghiorghes

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 1016 - 1016

Published: July 18, 2023

The iron chelating orphan drug deferiprone (L1), discovered over 40 years ago, has been used daily by patients across the world at high doses (75–100 mg/kg) for more than 30 with no serious toxicity. level of safety and simple, inexpensive synthesis are some many unique properties L1, which played a major role in contribution transition thalassaemia from fatal to chronic disease. Other valuable clinical L1 relation pharmacology metabolism include: oral effectiveness, improved compliance compared prototype therapy subcutaneous deferoxamine; highly effective removal all iron-loaded organs, particularly heart, is target organ toxicity cause mortality thalassaemic patients; an ability achieve negative balance, completely remove excess iron, maintain normal stores rapid absorption stomach clearance body, allowing greater frequency repeated administration overall increased efficacy excretion, dependent on dose also concentration achieved site action; its cross blood–brain barrier treat malignant, neurological, microbial diseases affecting brain. Some differential pharmacological activity among generally shown absorption, distribution, metabolism, elimination, (ADMET) drug. Unique exhibited comparison other drugs include specific protein interactions antioxidant effects, such as transferrin lactoferrin; inhibition copper catalytic production free radicals, ferroptosis, cuproptosis; iron-containing proteins associated different pathological conditions. have attracted interest investigators repurposing use conditions, including cancer, neurodegenerative renal radical pathology, metal intoxication Fe, Cu, Al, Zn, Ga, In, U, Pu, diseases. Similarly, increase prospects wider optimizing therapeutic efforts fields medicine, synergies drugs.

Language: Английский

Citations

12
Senescence and Sexual Aging: Implications for Men and Women DOI

Anuja Pant,

Akshay Kumar, Pawan Kumar Maurya

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Protective Effects of Centella asiatica Against Senescence and Apoptosis in Epidermal Cells DOI Creative Commons
Yu Rong Tan,

Ailing Hu,

Jingya Lu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 202 - 202

Published: Feb. 14, 2025

Centella asiatica, a traditional medicinal plant, possesses potent antioxidant activity and may therefore prevent cellular aging exert antiapoptotic effects. However, these effects remain to be fully elucidated. This study aimed investigate the protective of C. asiatica extract against senescence apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress in human epidermal keratinocytes (HaCaT cells). To evaluate H2O2 on HaCaT cells, we measured cell viability as marker death; reactive oxygen species (ROS), radical scavenging, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase activities markers stress; senescence-associated β-galactosidase (SA-β-gal) senescence; caspase-3/9 apoptotic cells apoptosis. induced death (decreased viability), (increased ROS activity, decreased SOD, GPx, activities), SA-β-gal activity), early/late increased activities). significantly all H2O2-induced death, stress, senescence, apoptosis, suggesting its ability through activity. mechanism action contribute prevention improvement skin aging.

Language: Английский

Citations

0