Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101285 - 101285
Published: March 1, 2025
Language: Английский
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: April 3, 2024
The intricate parallels in structure and function between the human retina central nervous system designate as a prospective avenue for understanding brain-related processes. This review extensively explores shared physiopathological mechanisms connecting age-related macular degeneration (AMD) proteinopathies, with specific focus on tauopathies. pivotal involvement of oxidative stress cellular senescence emerges key drivers pathogenesis both conditions. Uncovering these elements not only has potential to enhance our neurodegenerative diseases but also sets stage pioneering therapeutic approaches AMD.
Language: Английский
Citations
4
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 690 - 690
Published: May 27, 2024
(1) Background: Oxidative stress plays a pivotal role in the pathogenesis of various diseases, including neurodegenerative disorders, cardiovascular cancer, and diabetes, highlighting pressing need for effective antioxidant interventions. (2) Methods: In this study, we aimed to develop characterise two novel formulations, F3 F4, as therapeutic interventions oxidative stress-related conditions. (3) Results: The physicochemical characterisation, preformulation analysis, formulation, preparation filling powders capsules, capsule content evaluation, activity assessment formulations were assessed. These comprise combination well-established antioxidants like quercetin, biotin, coenzyme Q10, resveratrol. Through comprehensive testing, formulations' efficacy, stability, potential synergistic interactions evaluated. (4) Conclusions: findings underscore promising these disorders highlight significance mitigating their progression.
Language: Английский
Citations
4
Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1288 - 1288
Published: Oct. 24, 2024
Global aging represents a challenge for social health [...].
Language: Английский
Citations
4
Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1356 - 1356
Published: Oct. 24, 2024
Oxidative stress plays a crucial role in the pathogenesis of various ocular degenerative diseases, leading to structural and functional changes eye tissues. This imbalance between reactive oxygen species (ROS) antioxidants significantly contributes conditions such as age-related macular degeneration, diabetic retinopathy, cataracts, glaucoma. Both enzymatic nonenzymatic are vital for maintaining health by neutralizing ROS restoring cellular redox balance. Essential trace elements, including iron, zinc, copper, selenium, fundamental proper functioning these antioxidant systems. Iron is indispensable activity energy production, zinc supports numerous proteins involved visual functions defense, copper essential reactions preventing oxidative stress, selenium critical enzymes glutathione peroxidase (GPX) thioredoxin reductase (TrxR). review summarizes current research on complex interactions elements highlighting therapeutic potential supplementation mitigate damage improve health. By integrating insights from studies physiology, this article underscores new diagnostic strategies that could lead more effective prevention treatment aiming enhance clinical outcomes guide future optimizing
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 11, 2025
Age-related macular degeneration (AMD) is a major cause of vision loss among adults. We investigated the protective effects passion fruit seed extract (PFSE) and its rich polyphenol piceatannol in an AMD cell model which human retinal pigment epithelial ARPE-19 cells were exposed to hydrogen peroxide (H2O2). Using viability WST-8 assay, we revealed that PFSE increased cellular by 130% 133%, respectively. Moreover, recovered cells, had decreased 60% owing H2O2-induced damage, approximately 84% 89%, In addition, found treatment with H2O2 mitochondrial glycolytic ATP production rate 54% healthy control using Seahorse extracellular flux analyzer. Furthermore, pretreatment restored oxidative stress-induced decrease 97% 82%, These results indicated cytoprotective against stress resolving dysfunction energy metabolism.
Language: Английский
Citations
0
Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Age-related macular degeneration (AMD) poses a significant threat to visual health among the elderly, necessitating urgent preventive measures as global population ages. Extensive research has implicated oxidative stress (OS)-induced retinal damage primary contributor AMD pathogenesis, prompting investigations into potential therapeutic interventions. Among various nutrients studied for their in risk reduction, antioxidants have shown promise, with initial findings from Age-Related Eye Disease Study suggesting correlation between antioxidant supplementation and decreased progression. This article explores scientific foundation supporting efficacy of tocotrienol-rich fraction (TRF) viable candidate slowing progression, based on interventional studies. is characterized by OS, inflammation, dysregulated lipid metabolism, angiogenesis, all which TRF purportedly addresses through its potent anti-inflammatory, lipid-lowering, antiangiogenic, properties. The review underscores TRF's promising attributes, aiming deepen understanding pathogenesis advocate TRF-based pharmacological interventions enhance outcomes. Given pressing need effective treatments, represents avenue intervention, offering hope improved vision outcomes enhanced quality life individuals affected this debilitating condition.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 247 - 251
Published: Jan. 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 10, 2025
Trafficking defects in retinal pigmented epithelial (RPE) cells contribute to RPE atrophy, a hallmark of geographic atrophy (GA) dry age-related macular degeneration (AMD). Dry AMD pathogenesis is multifactorial, including amyloid-β (Aβ) accumulation and oxidative stress-common features Alzheimer's disease (AD). The Sigma-2 receptor (S2R) regulates lipid protein trafficking, S2R modulators reverse trafficking deficits neurodegeneration vitro models. Given overlapping mechanisms contributing AD AMD, modulator effects on function were investigated. CT1812 clinical trials for AD, dementia with Lewy bodies, GA. Leveraging testing CT1812, unbiased analyses patient biofluid proteomes revealed that proteins altered by associated GA ontologies overlapped AMD. Differential expression analysis transcripts from APP-Swedish/London mutant transgenic mice, model featuring Aβ accumulation, reversal autophagy/trafficking modulator-treated animals versus vehicle toward healthy control levels. Photoreceptor outer segment (POS) human showed response Aβ1-42 or hydrogen peroxide compared vehicle. normalized stressor-induced POS deficits, resembling control. Taken together, modulation may provide novel therapeutic strategy
Language: Английский
Citations
0
JCI Insight, Journal Year: 2025, Volume and Issue: 10(3)
Published: Feb. 10, 2025
The high-temperature requirement A1 (HTRA1), a serine protease, has been demonstrated to play pivotal role in the extracellular matrix (ECM) and reported be associated with pathogenesis of age-related macular degeneration (AMD). To delineate its retina, phenotype homozygous Htra1-KO (Htra1-/-) mice was characterized examine effect Htra1 loss on retina retinal pigment epithelium (RPE) age. ablation led significant reduction rod cone photoreceptor function, primary abnormalities followed by rods, atrophy RPE compared WT mice. Ultrastructural analysis Htra1-/- revealed Bruch's membrane (BM) abnormalities, including presence sub-RPE deposits at 5 months (m) that progressed age accompanied increased severity pathology. also displayed alterations key markers for inflammation, autophagy, lipid metabolism retina. These results highlight crucial HTRA1 RPE. Furthermore, this study allows mouse model utilized deciphering mechanisms lead deposit phenotypes AMD.
Language: Английский
Citations
0