Unraveling the role of nanoparticles in improving plant resilience under environmental stress condition

Plant and Soil, Journal Year: 2024, Volume and Issue: 503(1-2), P. 313 - 330

Published: March 12, 2024

Abstract Background As the world grapples with increasing agricultural demands and unpredictable environmental stressors, there is a pressing need to improve plant resilience. Therefore, understanding pioneering role of nanoparticles in alleviating stress crucial for developing stress-resilient varieties enhance food secure world. Nanoparticles have unique physical chemical properties, demonstrate their potential growth, nutrient utilization, tolerance. This review delves into mechanistic insights nanoparticle-plant interactions, highlighting how these tiny particles can mitigate diverse stressors such as drought, salinity, heavy metal toxicity. The action different types nanoparticles, including metal, carbon-based, biogenic are discussed context interaction physiology responses. Aims article also explores drawbacks implications nanoparticle use, emphasizing responsible sustainable applications. this study aimed offer exciting possibilities managing both biotic abiotic species, from improving water-use efficiency resilience via nanotechnology. Conclusions Future research directions suggested, focusing on nano-bioengineering precision agriculture create crops security. Through lens interdisciplinary research, paper underscores significance innovative tools realm agriculture, catalyzing paradigm shift towards farming systems.

Language: Английский

---

Recent advances in nano-related natural antioxidants, their extraction methods and applications in the food industry

Published: April 19, 2024

Natural antioxidants, such as phenolic compounds, carotenoids, vitamins, and microelements, are predominant in fruits, vegetables, herbs, spices. The accretion interest of consumers utilizing natural ingredients food products, have accelerated the appeal for functional “natural” operations. Therefore, understanding how antioxidants especially nano-antioxidants, their delivery systems when used antioxidant polymers packaging extracted from sources, would help prevent oxidation reactions. Given increasing role daily lives today’s communities, a continuous synthesis relevant literature is pertinent. To supplement existing information, recent advances nano-related extraction methods applications industry discussed this current work. Insightfully positioning within nano-delivery systems, work reveals potential nanotechnology provides enhancing absorption human metabolic systems.

Language: Английский

---

Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights

Liver Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---

Dual Functionality of Cobalt Oxide Nanoparticles: Exploring Their Potential as Antimicrobial and Anticancer Agents

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

---

Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.

Language: Английский

---

Nano-nutraceuticals to Combat Oxidative Stress: Unlocking Newer Paradigms in Adjuvant Therapy

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(17), P. 1490 - 1503

Published: May 6, 2024

Abstract: Nutraceuticals are products that provide both nutritional and therapeutic benefits. These compounds can slow the aging process physiological effects shielding individuals from acute chronic diseases. People's interests have shifted allopathic to Ayurvedic nutraceuticals in recent years. often common dietary supplements drawn customers worldwide because of their high safety lack adverse when used for a long time. Although conventional dosage forms, including pills, tablets, semi-solids, still available, they nevertheless poorer bioavailability, less stability, effectiveness targeted delivery bioactives. The use effective nanocomplex systems as nano-antioxidants using nanotechnology has become promising field. Among its many uses, is mostly create foods more bioavailable, toxic, sustainable. Additionally, it been emphasized how precisely nano-pharmaceuticals oxidative stress produce desired effects. improvements show improved antioxidant target region, reduced leakage, increased targeting precision. outcomes demonstrated stress-related illnesses be effectively treated by lowering ROS levels with nanonutraceuticals. major ideas uses nano-nutraceuticals health outlined this review, an emphasis on reducing stress.

Language: Английский

---

The Effect of Copper Nanoparticles on Liver Metabolism Depends on the Type of Dietary Fiber

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3645 - 3645

Published: Oct. 26, 2024

Background/Objectives: A diet enriched with copper nanoparticles (CuNPs) exhibits a wide range of effects on liver metabolism, both positive and negative. Dietary fibers are the key components that may affect absorption minerals, including copper, change their impact organisms. Methods: Therefore, this study investigated whether how supplementation different sources dietary fiber (cellulose, pectin, inulin, psyllium) affects function CuNPs in male Wistar rats. Results: The results showed at doses had varying lipid metabolism inflammation liver. Specifically, higher were associated increased accumulation activation pro-inflammatory mechanisms. However, combining fibers, such as psyllium was beneficial mitigating examined nanoparticles, leading to reduced fat, cholesterol, triglycerides Combining most substantial effect parameters. Furthermore, hepatic histology analyses adding reduces changes fat mononuclear cell infiltration. observed have been related reduction gene expression level sterol regulatory element-binding protein 1 peroxisome proliferator-activated receptor gamma cyclooxygenase-2. Conclusions: In conclusion, enriching can regulate action CuNPs, thereby improving reducing

Language: Английский

---

Evaluating the potential impact of sodium–glucose cotransporter‐2 inhibitor “canagliflozin” on the hepatic damage triggered by hypertension in rats

Microscopy Research and Technique, Journal Year: 2024, Volume and Issue: 87(12), P. 2929 - 2942

Published: July 25, 2024

Abstract Hypertension (HTN) is a prevalent chronic disease. HTN and liver disease association extensively noted. Thus, finding medication that can alleviate its accompanying insult would be promising. This study investigated the potential impacts of canagliflozin “sodium–glucose cotransporter‐2 inhibitor” on N ω ‐nitro‐L‐arginine methyl ester (L‐NAME)‐induced rat model. Twenty‐four adult male rats were divided into four groups; negative control group, L‐NAME group: 50 mg/kg was injected daily for 5 weeks + 1 week after injection both (40 mg/kg) given concomitantly further 4 weeks. Liver functions, serum lipid profile, hepatic oxidative/nitrative stress biomarkers, gene expression lipogenic enzymes, B‐cell lymphoma 2 (Bcl2), DNA fragmentation, measured. Besides, histology immunohistochemistry nuclear factor kappa B (NF‐κB) endothelial nitric oxide synthase (eNOS) assessed. Canagliflozin improved lipogenesis via downregulation fatty acid (FAS) transcriptional regulatory element binding protein 1c (SREBP1c) genes leading to an profile. Further, modified eNOS/inducible (iNOS) pathway decreased NF‐κB immunoreactivity besides restoring oxidants–antioxidants balance; increased reduced glutathione concomitant with declined malondialdehyde. improvement mirrored by significant restoration architecture confirmed preserved content upregulation antiapoptotic Bcl2 mRNA level attenuation alanine transaminase, aspartate aminotransferase. In conclusion, promising anti‐hypertensive hepatic‐supportive medication. Research Highlights Canagliflozin's antioxidant, anti‐inflammatory, anti‐lipogenic, characteristics mitigate remote compromise caused hypertension. exploited as hepatoprotective antihypertensive

Language: Английский

---

Phytotherapeutic approach to enhance the hepatoprotective activity of some edible plants: Molecular docking and nanoformulation

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106471 - 106471

Published: Sept. 21, 2024

Language: Английский

---

Antioxidants in Cardiovascular Disease

Antioxidants, Journal Year: 2024, Volume and Issue: unknown, P. 127 - 151

Published: Nov. 17, 2024

Cardiovascular diseases remain a significant global health burden, and understanding the molecular basis underlying their development progression is of utmost importance. Reactive oxygen species damage lipids, proteins, DNA, commencing cardiovascular ailment cascade. Oxidative assault promotes redox-sensitive signaling pathways such as nuclear factor-кβ Mitogen-activated protein kinases, increasing pro-inflammatory cytokines, adhesion molecules, chemokines. These molecules recruit express immune cells in vascular wall, including monocytes T lymphocytes. Toll-like receptors genes activated by dyslipidemia, especially increased LDL cholesterol, cause oxidative inflammation. NADPH activity can become dysregulated during assault, causing excessive generation prevailing over cellular antioxidant defense systems. Cytokines, growth hormones, vasoactive peptides like endothelin-1activate oxidase. oxidase activation angiotensin II affects calcium homeostasis assault. Calcium dysregulation causes damage. The also endothelial dysfunction early atherosclerosis. Inflammatory emit cytokines tumor necrosis factor-α interleukin 6, which increase inflammation smooth muscle cell proliferation migration. Plaque instability caused cells. Endothelial are insured from antioxidants, boost nitric oxide keep barrier intact. risk atherosclerosis disease decreased vitamin E carotenoids through decreasing oxidation oxidized formation. Antioxidants contribute to blood pressure management vasodilation production, improving flow, reducing pressure. In conclusion, key players developing progressing associated factors.

Language: Английский

---