Annals of Agricultural and Environmental Medicine, Journal Year: 2023, Volume and Issue: 30(4), P. 737 - 742
Published: Dec. 21, 2023
1. Wang Y, Xu H, Qian et al. Patients with Obstructive Sleep Apnea Display Decreased Flow-Mediated Dilatation: Evidence from a Meta-Analysis. Med Sci Monit. 2017;23:1069–1082. https://doi.org/10.12659/MSM.8.... CrossRef Google Scholar
Language: Английский
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 14, 2025
Accumulating research highlights that exposure to serum brominated flame retardants (BFRs) may elevate health risks. The effects of BFRs, both alone and in combination, on obstructive sleep apnea syndrome (OSAS) have not been thoroughly studied. Our main goal was examine the association between individual mixtures BFRs OSAS risk. Data from National Health Nutrition Examination Survey (NHANES) were employed, including 1,341 participants. We included participants with full details OSAS, covariates, 7 types (PBDE28, PBDE47, PBDE99, PBDE100, PBDE153, PBB153, PBDE209). To investigate risk exposure, multivariate logistic regression, weighted quantile sum (WQS) g-computation (QGC), Bayesian kernel machine regression (BKMR) models, restricted cubic splines (RCS) implemented. Serum PBDE28, showed positive correlations toxic effect co-exposure consistently demonstrated through results WQS QGC BKMR models. PBB153 determined be most BFRs. Additionally, RCS model also verified strong non-linear relationship existed PBB153. Findings study prove exerts a deleterious Future large-scale prospective investigations experimental studies are desirable confirm these findings.
Language: Английский
Citations
0
BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)
Published: June 19, 2024
Abstract Background Tinnitus affects approximately 740 million adults globally, involving hearing, emotion, and sleep systems. However, studies using polysomnography pure-tone audiometry (PTA) are limited. We aimed to assess the correlation between tinnitus quality, characteristics, depression PTA. Methods In this cross-sectional study, we divided participants into non-tinnitus groups. included 100 outpatients (65 with tinnitus, 35 without) from a medical center in Taiwan, who underwent completed rating scales including Patient Health Questionnaire-9 (PHQ-9), Chinese version of Pittsburgh Sleep Quality Index (PSQI), Chinese-Mandarin Handicap Inventory (THI-CM). analyzed correlations, conducted group comparisons, assessed factors related THI-CM scores, constructed ROC curves predict group, performed multinomial logistic regression explore associations. Results Descriptive statistics identified cohort mean age 53.9 ± 12.80 years, 63% exhibited PHQ-9 scores ≥ 10, 66% had Apnea–Hypopnea (AHI) > 5. The ratio rapid eye movement deep stage 1 + 2 was relatively low non-significant. Likewise, leg movements higher but not statistically significant. 63.08% depression, 81.54% AHI Univariate linked 5 (Odds (OR) 2.67, p = 0.026) male sex (OR 2.49, 0.034). A moderate positive found score (rs 0.50, < 0.001). Further adjustment for obstructive apnea showed associations (total score) or Grade 3–5 1.28; OR 8.68). Single- multifactor analyses highlighted significant PSQI 13 7.06, 0.018) 47 7.43, 0.002) depression. Conclusions Our study recruited slight mild hearing loss handicap. Depression as predominant factor tinnitus-related handicap may explain lack differences polysomnographic characteristics extensive prospective needed elucidate complex links among sleep, tinnitus.
Language: Английский
Citations
3
Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 731 - 746
Published: May 1, 2025
Sleep apnea syndrome (SAS) is a prevalent sleep disorder strongly associated with obesity, metabolic dysregulation, and cardiovascular diseases. While its underlying pathophysiological mechanisms remain incompletely understood, genetic factors likely play pivotal role in SAS pathogenesis. This study investigates the causal relationships between potential drug target genes using multiple statistical approaches, aiming to provide novel insights for targeted therapeutic development. We conducted comprehensive analysis integrating methodologies investigate gene-SAS relationships. Using publicly available GWAS eQTL databases, we performed Mendelian Randomization (MR) inverse variance weighted (IVW) method, validated by median MR-Egger approaches. Summary-data-based MR (SMR) analysis, coupled HEIDI testing, assessed direct gene expression-SAS associations while controlling linkage disequilibrium (LD). Colocalization evaluated probability of shared variants SNPs, expression, SAS. Statistical significance was determined Benjamini-Hochberg testing correction (FDR < 0.05). Additionally, mediation explored TEX10's influence on through intermediates including BMI, waist circumference, HDL cholesterol. identified 18 candidate significantly SAS, MAPKAPK3, TNXB, MPHOSPH8, TEX10 showing consistent across analyses. TEX10, particular, exhibited significant risk blood, cerebral cortex, hippocampus, basal ganglia (PP.H4 > 0.9). Mediation suggested that might indirectly cholesterol levels. Our targets causally linked emerging as key gene. These findings advance our understanding pathogenesis offer promising directions personalized diagnostics therapies.
Language: Английский
Citations
0
Bioengineering, Journal Year: 2024, Volume and Issue: 11(5), P. 438 - 438
Published: April 29, 2024
Background: Sensorineural hearing loss (SNHL) is a multifactorial disorder with potential links to various physiological systems, including the cardiovascular system via blood lipid levels such as triglycerides (TG). This study investigates causal relationship between TG and SNHL using Mendelian randomization (MR), which offers method reduce confounding reverse causality by genetic variants instrumental variables. Methods: Utilizing publicly available genome-wide association (GWAS) data, we performed two-sample MR analysis. The initial analysis unveiled (GWAS ID: ebi-a-GCST90018975) finn b-H8_HL_SEN-NAS). Subsequent validated this through larger sample size for ieu-b-111) SNHL. To conduct analysis, utilized several methods inverse-variance weighted (IVW), Egger, median, mode. We also employed Cochrane’s Q test identify any heterogeneity in results. detect horizontal pleiotropy, conducted MR-Egger intercept pleiotropy residual sum outliers (MR-PRESSO) test. leave-one-out assess sensitivity of association. Finally, meta-analysis results was undertaken. Results: Our found significant positive correlation SNHL, OR values 1.14 (95% CI: 1.07–1.23, p < 0.001) IVW 1.09 1.03–1.16, 0.006) replicate no evidence or (p > 0.05), confirmed stability robustness combining analyses showed effect 1.11 1.06–1.16, = 0.01). Conclusion: These findings indicate risk factor suggesting pathways prevention intervention populations at risk. conclusion underscores importance managing strategy mitigate developing
Language: Английский
Citations
3
Oxygen, Journal Year: 2024, Volume and Issue: 4(2), P. 150 - 162
Published: April 26, 2024
Background: In otorhinolaryngology and head neck surgery, oxygen is a therapeutic tool used for various pathologies. Oxidative stress the imbalance between production of free radicals (ROS) antioxidant capacity body, which can represent pathogenesis several pathologies or contribute to their worsening. This narrative review aims analyze benefits, indications, side effects hyperbaric therapy (HBOT) in different disorders. Methods: The search was carried out on multiple electronic databases such as PubMed Google Scholar, prospective, randomized, reviewed studies were analyzed from January 1982 February 2024. Results Conclusions: most common tools manage oxidative ear, nose, throat (ENT) field are continuous positive airway pressure (CPAP) HBOT. A ENT pathology, while latter be osteoradionecrosis treatment cancer patients, infections, malignant external otitis, reconstruction, facial cosmetic among patients with sudden sensorineural hearing loss. From our analysis, it emerged that HBOT currently effective pathologies’ treatment, alone association other treatments; guarantee functional recovery healing depending type pathology its severity.
Language: Английский
Citations
3
Sleep and Biological Rhythms, Journal Year: 2024, Volume and Issue: 22(4), P. 499 - 504
Published: June 15, 2024
Language: Английский
Citations
2
The Egyptian Heart Journal, Journal Year: 2024, Volume and Issue: 76(1)
Published: July 30, 2024
Abstract Background Atrial fibrillation (AF) is characterized by the absence of p-waves on ECG and irregular rhythm. It often presents with palpitations either may occur acutely over a short period or intermittently several years. Other cardinal symptoms atrial include fatigue, dyspnea, lightheadedness; it important however to note that most affected individuals are asymptomatic. Concurrently, sleep disorders such as obstructive apnea (OSA), insomnia, narcolepsy, circadian rhythm which group conditions associated body’s internal clock affect timing alertness, raising concerns due their potential associations arrhythmias. This review explores bidirectional relationship between AF disorders, highlighting implications for risk stratification management strategies. Main body The narrative approach this synthesizes evidence from numerous studies obtained through meticulous literature searches. Specific focus, scrutiny prevalence connection. examination delves into pathophysiology sleep-related autonomic dysregulation inflammation, emphasizing modalities. Various meta-analysis cohorts have highlighted strong connection (AF). Patients especially OSA, higher likelihood developing AF, conversely, those more prone disorders. impact not limited development, also contribute progression in turn, negatively impacting duration quality. Sleep play an role remodeling well electrophysiological abnormalities, rendering tissue susceptible arrhythmogenesis. suggests treating could only improve quality but reduce factors fibrillation. effective emerges challenge preventing Conclusion In conclusion, study highlights There positive correlation, affecting progression, detrimental abnormalities underscores significance diagnosis treatment. Education about importance benefits disorder treatment becomes imperative patients
Language: Английский
Citations
2
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Oct. 9, 2023
Metabolic syndrome (MetS) is an underlying cause of various diseases and strongly associated with mortality. In particular, it has been steadily increasing along changes in diet lifestyle habits. The close relationship between sleep apnea MetS well established. addition, these two share a common factor obesity have high prevalence among obese individuals. Nevertheless, the association can vary depending on factors, such as race sex, research relatively low rates East Asians lacking. This study aimed to investigate snoring nonobese Koreans. A total 2478 participants (827 men 1651 women) were enrolled Korean National Health Nutrition Examination Survey from 2019 2020. We used Cholesterol Education Program Adult Treatment Panel III criteria for questionnaire. Logistic regression analysis was measure confounding factors according age sex body mass index (BMI) < 23 kg/m2. significantly higher than those without (26.9% vs. 19.6%; p = 0.007). multivariate logistic analysis, (odds ratio [OR] 1.070, 95% confidence interval [CI] 1.059-1.082, .001), (OR 1.531, CI 1.139-2.058, 0.005), 1.442, 1.050-1.979, 0.024) patients BMI Finally, showed that women less kg/m2, especially younger ages (40-49 years, OR 4.449, 1.088 18.197, 0.038). Snoring closely aged 40-50 years kg/m2 compared other participants. However, not found 60 over. Therefore, sufficient consideration should be given possibility when present middle-aged Asian women.
Language: Английский
Citations
3
Biomedical Reviews, Journal Year: 2023, Volume and Issue: 34(0), P. 13 - 13
Published: Dec. 31, 2023
Reactive oxygen species (ROS), reactive nitrogen (RNS) and diffusible (DRS), under certain concentrations, play an important role at the physiological level. The of antioxidant molecules, endogenous exogenous, is to maintain adequate amounts ROS RNS. increase in RNS due overproduction these or a decrease molecules leads phenomenon called oxidative stress. Oxidative stress involved process aging but implicated pathologies such as some types tumors, neurodegenerative autoimmune disorders, male infertility, cardiovascular disorders atrial fibrillation, lung chronic obstructive pulmonary hypertension. This involvement has aroused widespread interest, especially because many studies try exploit it therapeutic purpose this review discuss which for reason, can be targeted intervention improve cure pathology; sometimes modulation used effect therapy.
Language: Английский
Citations
2
Annals of Agricultural and Environmental Medicine, Journal Year: 2023, Volume and Issue: 30(4), P. 737 - 742
Published: Dec. 21, 2023
1. Wang Y, Xu H, Qian et al. Patients with Obstructive Sleep Apnea Display Decreased Flow-Mediated Dilatation: Evidence from a Meta-Analysis. Med Sci Monit. 2017;23:1069–1082. https://doi.org/10.12659/MSM.8.... CrossRef Google Scholar
Language: Английский
Citations
0