Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer’s Disease Risk DOI Open Access
Tianqi Li, Mohammad Fili,

Parvin Mohammadiarvejeh

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4303 - 4303

Published: Dec. 13, 2024

Background: Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing performance preventing decline. Methods: This study utilized data from the UK Biobank cohort (n = 12,025) to examine associations between filtered coffee, green tea, standard consumption neural network functional connectivity across seven resting-state networks. We focused networks spanning prefrontal occipital areas that linked complex behavioral functions. Linear mixed models were used assess main of coffee consumption, as well interactions with Apolipoprotein E (APOE) genetic risk—the strongest risk factor Alzheimer’s disease (AD). Results: Higher was associated increased in several networks, including Motor Execution, Sensorimotor, Fronto-Cingular, a Prefrontal + ‘What’ Pathway Network. Similarly, greater intake enhanced Extrastriate Visual Primary Networks. In contrast, higher reduced such Memory Consolidation, “What” The APOE4 genotype family history AD influenced relationship Consolidation Additionally, modified association Sensorimotor Conclusions: distinct patterns brain activity may provide insights into AD-related changes. genotype, particular, appears play significant role modulating these relationships. These findings enhance our knowledge how commonly beverages influence potentially among older adults.

Language: Английский

Quantitative analysis of epigallocatechin-3-gallate in treating renal injury via meta-analysis and machine learning DOI
Jie Chen, Jianniao Tian, Yuanhao Zhang

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0
Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders DOI Creative Commons
Neha Kamboj,

S.D. Sharma,

Rahul Kumar

et al.

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.

Language: Английский

Citations

0
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer’s Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids DOI Open Access
Mahsa Yavari, Nishan S. Kalupahana, Breanna N. Harris

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1203 - 1203

Published: March 29, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and behavioral changes. It poses significant global health challenge. AD associated with the accumulation of amyloid-β (Aβ) plaques neurofibrillary tangles (NFTs) in brain, along chronic inflammation, dysfunctional neurons, synapse loss. While prevalence continues to rise, current FDA-approved drugs offer only limited effectiveness. Emerging evidence suggests that obesity, insulin resistance (IR), type 2 diabetes mellitus (T2DM) are also implicated pathogenesis, epidemiological studies animal models confirming impact IR on Aβ accumulation, high-fat diets exacerbating accumulation. Since neuroinflammation activated involves nuclear factor kappa-light-chain-enhancer B cell (NF-κB) pathway, inhibition NF-κB NLRP3 inflammasome activation potential therapeutic strategies AD. Bioactive compounds, including polyphenols (resveratrol, epigallocatechin-3-gallate, curcumin, quercetin), omega-3 polyunsaturated fatty acids, show promising results clinical trials for reducing levels, improving cognition modulating signaling pathways This review explores interplay between IR, pathology, emphasizing dietary compounds their role oxidative stress, as viable prevention treatment. By integrating findings, observational studies, trials, this aims provide comprehensive understating how metabolic dysfunctions bioactive influence progression.

Language: Английский

Citations

0
Regulation of Apoptotic Pathways by MicroRNAs: A Therapeutic Strategy for Alzheimer’s Disease DOI
Mohamed J. Saadh,

Faris Anad Muhammad,

Tuqa S. Alazzawi

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
Harnessing nutrients and natural products for sustainable drug development against aging DOI Creative Commons
Fan Ding, Ying Yu, Yan Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Developing treatments for age-related diseases requires cost-effective and efficient approaches. Nutrients natural metabolites offer safer alternatives to synthetic drugs. Aging increases the need solutions that protect health repair cells. Recent studies show nutrients products reduce oxidative stress, regulate metabolism, influence longevity-related genes. This review focuses on vitamins, minerals, antioxidants, improve healthspan combat aging. It also discusses challenges such as standardization, clinical validation, regulatory approval. Finally, emerging trends, personalized nutrition advanced delivery systems, highlight potential of these addressing

Language: Английский

Citations

0
Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases DOI Creative Commons
Sri Jayanti, Libor Vı́tek, Camilla Dalla Verde

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 63 - 63

Published: Jan. 2, 2024

The crucial physiological process of heme breakdown yields biliverdin (BV) and bilirubin (BR) as byproducts. BV, BR, the enzymes involved in their production (the “yellow players—YP”) are increasingly documented endogenous modulators human health. Mildly elevated serum concentration has been correlated with a reduced risk multiple chronic pro-oxidant pro-inflammatory diseases, especially elderly. BR BV per se have demonstrated to protect against neurodegenerative which oxygenase (HMOX), main enzyme pigments, is almost always altered. HMOX upregulation interpreted tentative defense ongoing pathologic mechanisms. With demonstration that cells possess YP, propensity be modulated, broad spectrum activity on signaling pathways, YP assumed role an adjustable system can promote health adults. Based that, there effort induce therapeutic option, natural compounds attractive alternative goal, possibly requiring only minimal changes life style. We review most recent evidence potential targeting context common condition adult elderly life.

Language: Английский

Citations

3
A More Holistic Perspective of Alzheimer's Disease: Roles of Gut Microbiome, Adipocytes, HPA Axis, Melatonergic Pathway and Astrocyte Mitochondria in the Emergence of Autoimmunity DOI Creative Commons
George Anderson

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(12), P. 355 - 355

Published: Dec. 28, 2023

Alzheimer's disease is widely regarded as poorly treated due to poor conceptualization. For 40 years, pathophysiology has focused on two culprits, amyloid-β induced plaques and hyperphosphorylated tau associated tangles, with no significant treatment advance. This confounded by data showing be an endogenous antimicrobial that increased in a wide array of diverse medical conditions heightened inflammation. article reviews the wider bodies pertaining pathophysiology, highlighting role suppressed astrocyte mitochondrial function melatonergic pathway core hub driving neuronal loss dementia. It proposed over aging becomes dysregulated, at least partly mediated systemic processes involving 10-fold decrease pineal melatonin leading attenuated capacity night-time dampen residual daytime Suppressed also attenuates melatonin's inhibition glucocorticoid receptor nuclear translocation, thereby changing not only stress/hypothalamus-pituitary-adrenal (HPA) axis consequences but cortisol awakening response, which 'primes body for coming day'. Gut microbiome-derived butyrate inhibits well inducing pathway. prevents autocrine paracrine effects limiting levels effects. production induction lactate, decreasing metabolism The lactate melatonin, coupled suppression decreases mitophagy, major histocompatibility complex (MHC)-1. MHC-1 initiates chemoattraction CD8+ t cells, destruction being driven 'autoimmune'/'immune-mediated' processes. may therefore conceptualized initiated act astrocytes hub, leaving neurons deplete appropriate metabolic substrates co-ordinated antioxidants. culminates 'immune-mediated' cell death. Future research treatment/prevention implications are indicated.

Language: Английский

Citations

8
Epigallocatechin-3-gallate Inhibits LPS/AβO-induced Neuroinflammation in BV2 Cells through Regulating the ROS/TXNIP/NLRP3 Pathway DOI
Yanyan Xiao, Chenglin Yang,

Nana Si

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)

Published: June 18, 2024

Language: Английский

Citations

3
Analysis of the anti-Alzheimer potential of bioactive compounds from Citrus hystrix DC. peel, leaf, and essential oil by network pharmacology DOI Creative Commons

Adhisa Fathirisari Putri,

Didik Huswo Utomo, Woro Anindito Sri Tunjung

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33496 - e33496

Published: June 26, 2024

Alzheimer's disease (AD) is the most known neurodegenerative disease, and its prevalence predicted to increase significantly. Discovering novel drugs treatments for AD urgently needed. Drugs from natural products have been preferred lately due their high potential low toxicity. Citrus hystrix DC. (kaffir lime; KL) one such herbal plant that found abundantly in Southeast Asia with many biological activities. In this study, of bioactive compounds KL peel, leaf, essential oil as anti-AD agents was explored using network pharmacology. First, were identified KNApSAcK database related literature. Subsequently, targets each corresponding compound determined SEA Search Server Swiss Target Prediction proteins associated OMIM, GenCLiP3, DisGeNET. Furthermore, a protein–protein interaction compound–target constructed identify crucial by employing Cytoscape v3.9.1. The study continued pathway enrichment analysis STRING v1.7.1, molecular docking PyRx SwissDock, dynamics simulation YASARA further confirmation. Our results showed almost all secondary metabolites targeted AD-associated genes, oxypeucedanin citrusoside A showing highest targeting EGFR MAPK14, respectively. These inflammatory oxidative stress pathways, indicating mechanism attenuating clinical manifestation.

Language: Английский

Citations

2
Development of Epigallocatechin and Ascorbic Acid Dual Delivery Transferosomes for Managing Alzheimer’s Disease: In Vitro and in Vivo Studies DOI Creative Commons
Gaurav Mishra, Rajendra Awasthi, Sunil Kumar Mishra

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(33), P. 35463 - 35474

Published: Aug. 7, 2024

Epigallocatechin-3-gallate (EGCG) and ascorbic acid (AA)-loaded transferosomes (TRANS) were developed for brain delivery. The investigation covered EGCG-TRANS, AA-TRANS, EGCG-AA-TRANS formulations using the film hydration technique. We analyzed formed to confirm presence of vesicles loaded with respective drugs their performance within a living organism. sizes particles measured correspondingly at 174.2 ± 1.80, 132.7 12.22, 184.31 9.5 nm. appearance diffused rings in scanning electron microscopic image suggests that payload has crystalline structure. atomic force microscope displayed minimal surface irregularities, potentially indicating lipid layer on surface. Hemolysis results indicated safety vesicles. showed 10.23, 7.21, 8.20% hemolysis EGCG-AA-TRANS, respectively. In case release EGCG was determined be 61.65% 4.61 after 72 h when exposed phosphate buffer saline (pH 7.4). vivo studies show good response against Alzheimer's disease (AD). (82.166%) exhibited higher percentage AChE inhibition comparison EGCG-TRANS (66.550%) AA-TRANS (53.466%). Intranasal delivery resulted approximately 5-fold enhancement memory. Formulation allowed AA accumulate various organs, including brain. suggest could safe effective treating AD.

Language: Английский

Citations

2