Beta-Thalassemia and Male Infertility: Unraveling the Oxidative Stress Connection—An Up-to-Date Review DOI Creative Commons

Christos Roidos,

Christos-Alexandros Batakoias, Evangelos N. Symeonidis

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2789 - 2789

Published: Dec. 12, 2024

Background/Objectives: Beta-thalassemia (BTH), a genetic disorder resulting from beta-globin gene mutations, affects over 1.5 million people globally. The disorder’s multifactorial impact on male fertility, particularly through oxidative stress (OS), warrants focused study. This review examines the mechanisms of OS in TM, its implications for infertility, and potential antioxidant therapies to mitigate fertility challenges. Methods: A non-systematic was conducted using PubMed, Cochrane, Medscape databases, focusing studies beta-thalassemia erectile dysfunction (ED), hormonal alterations, OS. Studies were screened based relevance, language, topic, with 71 articles meeting inclusion criteria after removing duplicates. Results: findings reveal that OS, exacerbated by iron overload regular blood transfusions, is significantly associated impaired sperm quality patients TM. Iron toxicity gonadotropin levels, reduces quality, contributes hypogonadism. Additionally, show promise reducing OS-induced damage, though efficacy limited lack robust clinical trials. Conclusions: plays considerable role infertility among primarily iron-induced damage disruptions. While may offer partial remedy, further research necessary understand OS’s TM develop effective treatments. highlights need personalized approaches improve reproductive outcomes this population.

Language: Английский

From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology DOI Creative Commons
Aris Kaltsas, Fotios Dimitriadis, Dimitrios Zachariou

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1835 - 1835

Published: Oct. 15, 2023

Infertility is a global health concern, with male factors playing an especially large role. Unfortunately, however, the contributions made by reproductive urologists in managing infertility under assisted technology (ART) often go undervalued. This narrative review highlights important role played diagnosing and treating as well any barriers they face when providing services. manuscript presents comprehensive of urologists' infertility, outlining their expertise reversible causes performing surgical techniques such sperm retrieval. investigates limiting urologist involvement limited availability, awareness among healthcare professionals, financial constraints. study decrease fertility due to lifestyle like sedentary behavior, obesity, substance abuse. It stresses significance conducting evaluation process involving both female partners identify underlying contributing patients who do not require interventions beyond ART. We conclude that engaging more effectively management key optimizing outcomes couples undergoing treatments requires greater education providers regarding could have effect on fertility.

Language: Английский

Citations

10
The influence of SARS‐CoV‐2 on male reproduction and men's health DOI
Ayad M. Ali,

Rahel F. Abdlwahid,

Kameran M. Ali

et al.

European Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 54(1)

Published: Sept. 19, 2023

Abstract Background SARS‐CoV‐2, the virus responsible for COVID‐19, primarily affects respiratory system by targeting Angiotensin‐converting enzyme 2 (ACE2) receptor and TMPRSS2. However, these receptors are also present in other organs, including testes, where a higher concentration of ACE2 has been observed. This raises concerns about potential impact on male fertility. Aims In this study, we aimed to assess effects SARS‐CoV‐2 semen parameters comparing samples during after infection same patients. Materials & Method The study enrolled 51 individuals who had contracted COVID‐19 analysed various related sperm quality quantity, C‐reactive protein, testosterone levels, total concentration, motility morphology. A comparison was made between initial with 2‐ 5‐month recovery period. Results results indicated that all mentioned were significantly affected (PCR‐ct, CRP, WBCs LH, FSH p ‐value = .0001). Furthermore, assessed TC, TM morphology patients infected found influenced infection, ( .0001; Morphology, .0004). We observed significant alterations count suggesting negative quality. Additionally, lower hormone levels possibly due increased inflammatory cytokines. both hormones inflammation markers returned normal following recovery. Our findings indicate statistically change count, post‐infection, which aligns previous studies. Discussion, have transient fertility, emphasizing importance further investigation into long‐term implications.

Language: Английский

Citations

7
Sperm quality and sexual function after the first COVID-19 infection during the omicron surge: an observational study in southwest China DOI Open Access
Tingting Yang, Bo Liu, Xiaohong Luo

et al.

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(9), P. 1835 - 1846

Published: Sept. 1, 2024

As the Omicron variant became dominant coronavirus disease 2019 (COVID-19) strain and threat to human health decreased, impact of COVID-19 on male reproductive semen quality may have changed. In this prospective observational study, we aimed investigate changes in sexual function before after infection by self-controlled study explore influence health.

Language: Английский

Citations

1
Beta-Thalassemia and Male Infertility: Unraveling the Oxidative Stress Connection—An Up-to-Date Review DOI Creative Commons

Christos Roidos,

Christos-Alexandros Batakoias, Evangelos N. Symeonidis

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2789 - 2789

Published: Dec. 12, 2024

Background/Objectives: Beta-thalassemia (BTH), a genetic disorder resulting from beta-globin gene mutations, affects over 1.5 million people globally. The disorder’s multifactorial impact on male fertility, particularly through oxidative stress (OS), warrants focused study. This review examines the mechanisms of OS in TM, its implications for infertility, and potential antioxidant therapies to mitigate fertility challenges. Methods: A non-systematic was conducted using PubMed, Cochrane, Medscape databases, focusing studies beta-thalassemia erectile dysfunction (ED), hormonal alterations, OS. Studies were screened based relevance, language, topic, with 71 articles meeting inclusion criteria after removing duplicates. Results: findings reveal that OS, exacerbated by iron overload regular blood transfusions, is significantly associated impaired sperm quality patients TM. Iron toxicity gonadotropin levels, reduces quality, contributes hypogonadism. Additionally, show promise reducing OS-induced damage, though efficacy limited lack robust clinical trials. Conclusions: plays considerable role infertility among primarily iron-induced damage disruptions. While may offer partial remedy, further research necessary understand OS’s TM develop effective treatments. highlights need personalized approaches improve reproductive outcomes this population.

Language: Английский

Citations

0