Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study

European Heart Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Several studies have supported the role of innate immune system as a key factor in sterile inflammation underlying pathophysiology atherosclerosis mice. However, its involvement humans remains unclear. This study aimed to explore association between neutrophil count, and intima-media thickness common carotid arteries (IMT-CC), well potential impact long-term dietary interventions on these associations.

Language: Английский

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The association between consumption of ultra-processed foods and sperm quality parameters: a cross-sectional study

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 1, 2025

While recent studies suggest a correlation between unhealthy dietary patterns, oxidative stress, inflammation, and male infertility, the potential association ultra-processed foods (UPFs) infertility remains underexplored. Therefore, aim of present study was to investigate UPF intake by evaluating sperm quality parameters. The participants (n = 260) current cross-sectional were recruited from an center in Isfahan Province, Iran. Four semen parameters—such as total motility, concentration, volume, normal morphology—were evaluated. Also, participants' food assessed using validated 168-item frequency questionnaire. Moreover, NOVA system employed calculate index. UPFs parameters analyzed logistic regression. In crude model, no significant associations observed second last tertiles with abnormalities morphology (p > 0.05 for all). However, after adjusting age, marriage duration, body mass index, physical activity, depression, anxiety, energy intake, cigarette history, mineral vitamin supplements, significantly higher identified tertile concentration (odds ratio (OR) 3.962, 95% confidence interval (CI): 1.345–11.670, p 0.013). conclusion, although analysis did not find consumption impaired motility morphology, it revealed trends linking lower concentration. If future confirm these results, they could aid designing interventional preventive programs aimed at addressing men reproductive age field public health.

Language: Английский

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The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Abstract Background Longitudinal cohort studies across the lifespan suggest an association between ultra-processed food (UPF) and depression. However, effect of UPF on depression mental health in older adults has not been determined. Therefore, this study investigated depressive symptoms community-dwelling adults. Methods A pragmatic target trial was designed emulated using ASPirin Reducing Events Elderly longitudinal data. Participants were (≥ 70 years) Australia. We specified protocol a two-arm randomised clinical level consumption as intervention. Greater than or equal to 4 servings per day considered intervention, with less control. Dietary assessed mail-based diet screening questionnaire, processing classified based NOVA classification. The outcomes symptoms, defined score ≥ 8 Center for Epidemiological Studies Depression 10-item scale, general health, by component summary Short Form-12. applied inverse probability treatment weighting balance confounders. Marginal structural models employed estimate population-level average intervention generalised estimated equations. Results total 11,192 participants (3415 7777 control) eligible emulation. High at time zero associated increased risk follow-ups (RR: 1.10; CI: 1.04–1.18). finding consistent sensitivity analyses; after excluding antidepressants zero, group 11% compared control 1.11; 95% (1.04–1.20)). Consumption adversely affected quality life ( β : − 0.40; 0.65 0.15). Conclusions higher among

Language: Английский

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How Do Polyphenol-Rich Foods Prevent Oxidative Stress and Maintain Gut Health?

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1570 - 1570

Published: July 31, 2024

Inflammatory bowel disease (IBD), which includes Crohn's and ulcerative colitis, involves chronic inflammatory disorders of the digestive tract. Oxidative stress, associated with increased reactive oxygen species generation, is a major risk factor for IBD pathogenesis. Industrialized lifestyles expose us to variety factors that contribute deteriorating gut health, especially patients. Many alternative therapeutic strategies have been developed against oxidative stress along conventional therapy alleviate Polyphenol-rich foods attracted growing interest from scientists due their antioxidant properties. Polyphenols are natural compounds found in plants, fruits, vegetables, nuts exhibit properties protect body damage. This review presents an overview polyphenol benefits describes different types polyphenols. It also discusses polyphenols' role inhibiting fungal growth prevention. Overall, this highlights how healthy balanced diet avoiding industrialized our modern society can minimize damage pathogen infections. polyphenol-rich play important protecting growth.

Language: Английский

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Associations between phthalate metabolites and two novel systemic inflammatory indexes: a cross-sectional analysis of NHANES data

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 24, 2025

The potentially risky effects of metabolites phthalates (mPAEs) on inflammation and immune function have attracted much attention in recent years. However, direct studies the relationship between these systemic inflammatory index (SII) response (SIRI) are limited. This cross-sectional study used generalized linear regression models (GLM), restricted cubic splines (RCS), weighted quantile sum (WQS), Bayesian kernel-machine (BKMR) to analyze data from 2,763 U.S. adults aged 20 80 years, obtained National Health Nutrition Examination Survey (NHANES) conducted 2013 2018. aimed investigate urine samples nine mPAEs levels SII/SIRI a single, nonlinear, mixed explored robustness findings under single using two sensitivity analyses for completeness. In addition, six variables (age, sex, BMI, percentage total daily energy intake ultra-processed foods (UPFs), vegetable intake, dietary supplements) association results were through subgroup identify important confounders. exposure analyses, mono-n-butyl phthalate (MnBP), mono-ethyl (MEP), monobenzyl (MBzP) positively associated with SII/SIRI. demonstrated positive collective concentrations SII/SIRI, MBzP being identified as significant contributor urinary mPAEs. analysis exposures show that is more females, overweight/obese populations, young/middle-aged populations high UPFs. Positive associations was determined most impact. significantly influenced by female groups, young middle-aged overweight obese individuals, well those higher

Language: Английский

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The Effects of Time-Restricted Eating on Inflammation and Oxidative Stress in Overweight Older Adults: A Pilot Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 322 - 322

Published: Jan. 17, 2025

Time-restricted eating (TRE) has been associated with beneficial effects for inflammation and oxidative stress; however, the of TRE on stress in aging population have not explored. This secondary analysis tested pro-inflammatory (hs-CRP [high-sensitivity C-reactive protein], IL-1β [interleukin 1 beta], IL-6 6], TNF-α [tumor necrosis factor alpha]) (8-isoprostane) biomarkers ten overweight older adults (mean age = 77.1 ± 6.1 years; six women four men), who followed a protocol 16 h fasting per day consumed food ad libitum during an 8 window 4 weeks. levels decreased from 43.2 (11.2) pg/mL to 39.7 (10.0) Cohen's d effect size 0.33, 1.4 (0.8) 1.3 (0.6) 0.23, suggesting potential anti-inflammatory benefits. hs-CRP showed no substantial changes (Cohen's ≤ 0.03). The marker 8-isoprostane slightly 0.07. findings this pilot study provide initial insights into inflammatory markers adults. Given small sample short-term intervention, well-powered studies longer duration are needed better understand populations.

Language: Английский

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Efecto del consumo de polifenoles sobre biomarcadores de inflamación y endotoxemia en personas con obesidad: una revisión sistemática.

Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria, Journal Year: 2025, Volume and Issue: 45(1)

Published: Feb. 3, 2025

Introducción: las enfermedades crónicas han aumentado a nivel mundial debido al estilo de vida y otros factores como el tabaquismo, alcohol, la obesidad, comida ultraprocesada baja en fibra, carente frutas verduras, etc. La evidencia científica respalda uso polifenoles dietarios agentes preventivos terapéuticos que podrían ayudar con carga estas patologías modulando respuesta inflamatoria endotoxemia. Objetivo: evaluar los efectos del consumo sobre parámetros relacionados biomarcadores inflamatorios endotoxemia, perfiles glucémicos peso personas esta condición. Metodología: Se realizó búsqueda ensayos clínicos aleatorizados bases datos PubMed, Science Direct, Ovid Ebsco. accedió estudios adultos obesos publicados entre enero 2019 hasta marzo 2024 evaluaran efecto inflamación (FNTα, PCR hs, IL6 e IL10) endotoxemia (LPS). Resultados: incluyeron 11 506 participantes. evidenció 73% más sensibles disminución fueron PCR, FNTα. Con relación lipoproteína fijadora lipopolisacáridos aumentó 30% grupo intervención no se afectaron. glicemia disminuyó promedio 15% mantuvo estable lo indica puedan ser, además, coadyuvantes manejo peso. Discusión: tolerancia modulación pero requieren estudios. Conclusión: fitonutrientes son sustancias prometedoras inflamación, pacientes obesidad.

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The Exposome and Its Influence on Toxicology, Illustrated by the Interaction Between Diet, Social Stress, and Chemicals

Published: Jan. 1, 2025

Language: Английский

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The Impact of Ultra-Processed Foods on Cardiovascular Diseases and Cancer: Epidemiological and Mechanistic Insights

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100072 - 100072

Published: March 1, 2025

Language: Английский

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UPFs and Shortened Lifespans: Ultra-Processed Foods Linked to Accelerated Biological Aging; Consequences Across Human Body Systems and Implications for Associated Medical Specialties

Scientia. Technology, science and society., Journal Year: 2025, Volume and Issue: 2(3), P. 13 - 36

Published: March 1, 2025

Ultra-processed foods (UPFs) are defined by their high levels of refined carbohydrates, unhealthy fats, artificial additives, and preservatives. These contribute to biological aging through mechanisms such as chronic inflammation, oxidative stress, metabolic dysfunction. Inflammation, disruptions in insulin signaling key factors the development aging-related diseases, including cardiovascular disease, diabetes, neurodegenerative disorders. Specifically, advanced glycation end-products (AGEs) epigenetic modifications significantly acceleration disrupting cellular function, promoting tissue damage, driving disease development. UPF consumption is linked cancer, gastrointestinal disorders, obstetric gynecological conditions, a range adverse effects on various body systems. Reducing intake encouraging healthier dietary patterns crucial for mitigating impact UPFs related health conditions. For individuals unable transition whole food-based diets, pharmaceutical medical interventions offer alternatives reduce UPF-related aging. A combined approach pharmacologic therapies adjustments may optimize outcomes, with ongoing research into novel treatments further enhancing strategies counteract effects. This review examines accelerating aging, which they associated potential mitigate

Language: Английский

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