Caralluma fimbriata Extract Improves Vascular Dysfunction in Obese Mice Fed a High-Fat Diet DOI Open Access
V. B. S. C. Thunuguntla, Laura Kate Gadanec,

C. McGrath

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4296 - 4296

Published: Dec. 12, 2024

Background: Obesity is a risk factor for developing cardiovascular diseases (CVDs) by impairing normal vascular function. Natural products are gaining momentum in the clinical setting due to their high efficacy and low toxicity. Caralluma fimbriata extract (CFE) has been shown control appetite promote weight loss; however, its effect on function remains poorly understood. This study aimed determine that CFE had loss mice fed high-fat diet (HFD) induce obesity, comparing this of lorcaserin (LOR) (an anti-obesity pharmaceutical) treatment. Methods: C57BL/6J male (n = 80) were 16-week HFD obesity prior being treated with LOR as standalone treatments or conjunction. Body composition data, such gain fat mass content measured, isometric tension analyses performed isolated abdominal aortic rings relaxation responses acetylcholine, immunohistochemistry studies utilized expression profiles endothelial nitric oxide synthase (eNOS) cell stress markers (nitrotyrosine (NT) 78 kDa glucose-regulated protein (GRP78)) endothelial, medial adventitial layers rings. Results: The results demonstrated + significantly reduced (17%; 24%) deposition (14%; 16%). A markedly acetylcholine-mediated (p < 0.05, p 0.0001) eNOS 0.0001, 0.01) increased NT GRP78 0.01, 0.001). Obese exhibited improved ACh-induced responses, expression. Conclusions: Thus, alone combination could serve an alternative strategy preventing obesity-related diseases.

Language: Английский

NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity DOI Creative Commons
Patrizia Amadio, Leonardo Sandrini, M Zara

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103060 - 103060

Published: Feb. 1, 2024

There is a complex interrelationship between the nervous system and cardiovascular system. Comorbidities of diseases (CVD) with mental disorders, vice versa, are prevalent. Adults disorders such as anxiety depression have higher risk developing CVD, people CVD an increased being diagnosed disorders. Oxidative stress one many pathways associated pathophysiology brain disease. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) major generators reactive oxygen species (ROS) in mammalian cells, it enzyme that specifically produces superoxide. This review summarizes recent findings on consequences NOX activation thrombosis depression. It also discusses therapeutic effects pharmacological strategies inhibitors A better comprehension these processes could facilitate development new approaches for prevention treatment comorbidity

Language: Английский

Citations

10
Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications DOI Creative Commons
Aditya Sri Listyoko,

Ryota Okazaki,

Tomoya Harada

et al.

Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5

Published: March 18, 2024

The prevalence of obesity among asthma patients has surged in recent years, posing a significant risk factor for uncontrolled asthma. Beyond its impact on severity and patients' quality life, is associated with reduced lung function, increased exacerbations, hospitalizations, heightened airway hyperresponsiveness, elevated asthma-related mortality. Obesity may lead to metabolic dysfunction immune dysregulation, fostering chronic inflammation characterized by pro-inflammatory mediators adipocytokines, reactive oxygen species, antioxidant activity. This holds the potential induce remodeling individuals obesity. Airway encompasses structural pathological changes, involving alterations airway's epithelial subepithelial layers, hyperplasia hypertrophy smooth muscle, changes vascularity. In obesity, underlie hyperresponsiveness severity, ultimately contributing development persistent airflow limitation, declining increase Despite efforts address outcomes, intricate mechanisms linking pathophysiology, particularly concerning remodeling, remain incompletely understood. comprehensive review discusses current research investigating influence enhance our understanding obesity's role context remodeling.

Language: Английский

Citations

5
Exploring Postharvest Metabolic Shifts and NOX2 Inhibitory Potential in Strawberry Fruits and Leaves via Untargeted LC-MS/MS and Chemometric Analysis DOI Creative Commons

Georgia Ladika,

Paris Christodoulou, Eftichia Kritsi

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 321 - 321

Published: May 13, 2025

Background/Objectives: Strawberries are highly appreciated for their rich phytochemical composition, but rapid postharvest deterioration limits shelf life and nutritional quality. This study aimed to investigate the metabolic changes occurring in both strawberry fruits leaves during storage evaluate NADPH oxidase 2 (NOX2) inhibitory potential of strawberry-derived metabolites. Methods: Untargeted LC-MS/MS analysis was conducted on fruit leaf tissues stored at 8 ± 0.5 °C. A total 37 metabolites were identified, including organic acids, phenolic flavonoids, hydroxycinnamic acid derivatives. Multivariate statistical analyses (ANOVA, PLS-DA, volcano plots) used assess temporal tissue-specific shifts. Additionally, a machine learning-based predictive model applied NOX2 24 structurally characterized Results: Storage induced significant changes. In fruits, malic acid, caffeic quercetin-3-glucuronide showed notable variations, while ellagic aglycone galloylquinic emerged as prominent markers leaves. The identified 21 out likely inhibitors, suggesting antioxidant anti-inflammatory bioactivity. Conclusions: These findings provide new insights into biochemical dynamics results highlight value source bioactive compounds support valorization functional food nutraceutical applications.

Language: Английский

Citations

0
The Vascular Function of Resistance Arteries Depends on NADPH Oxidase 4 and Is Exacerbated by Perivascular Adipose Tissue DOI Creative Commons
Patrick Diaba‐Nuhoho,

Jennifer Mittag,

Coy Brunßen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 503 - 503

Published: April 23, 2024

The NADPH oxidase NOX4 that releases H

Language: Английский

Citations

2
Stable Nitroxide as Diagnostic Tools for Monitoring of Oxidative Stress and Hypoalbuminemia in the Context of COVID-19 DOI Open Access
Ekaterina Georgieva, Julian Ananiev,

Y. Yovchev

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8045 - 8045

Published: July 24, 2024

Oxidative stress is a major source of ROS-mediated damage to macromolecules, tissues, and the whole body. It an important marker in severe picture pathological conditions. The discovery free radicals biological systems gives "start" studying various processes related development progression many diseases. From this moment on, enrichment knowledge about participation free-radical pathogenesis cardiovascular, neurodegenerative, endocrine diseases, inflammatory conditions, infections, including COVID-19, increasing exponentially. Excessive responses abnormal reactive oxygen species (ROS) levels may disrupt mitochondrial dynamics, risk cell damage. In addition, low serum albumin changes normal physiological balance between reduced oxidized can be serious prerequisite for impaired antioxidant capacity body, worsening condition patients. This review presents interrelationship oxidative stress, inflammation, levels, which are hallmarks COVID-19.

Language: Английский

Citations

2
Correlation between vascular endothelial function and bone mineral density in type 2 diabetes mellitus patients with MAFLD DOI

Peiyan Du,

Jianxiang Jiang,

Yu‐Rong Liu

et al.

Acta Cardiologica, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Dec. 10, 2024

Objective The relationship between vascular endothelial function and bone mineral density (BMD) in T2DM patients with metabolic dysfunction associated fatty liver (MAFLD) is still unclear. This study aims to analyse the correlation BMD or fracture risk MAFLD.

Language: Английский

Citations

2
Changed regulation of granulocyte NADPH oxidase activity in the mouse model of obesity-induced type 2 diabetes mellitus DOI
Irina V. Tikhonova,

A. R. Dyukina,

Andrei Anatolevich Grinevich

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 216, P. 33 - 45

Published: March 11, 2024

Language: Английский

Citations

1
Ophthalmic wild olive (ACEBUCHE) oil nanoemulsions exert oculoprotective effects against oxidative stress induced by arterial hypertension DOI Creative Commons
Álvaro Santana‐Garrido, Matilde Durán‐Lobato, Alfonso Mate

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 649, P. 123602 - 123602

Published: Nov. 13, 2023

Oxidative stress plays a key role in several systemic and ocular diseases, including hypertensive eye diseases. In this context, we previously showed that oral administration of wild olive (acebuche, ACE) oil from Olea europaea var. sylvestris can counteract damage secondary to arterial hypertension by modulating excess reactive oxygen species (ROS) produced the enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Therefore, work describes development an ACE oil-based formulation for as local therapy hypertension-related oxidative damage. Specifically, nanoemulsions (NEs) were successfully characterized, exhibiting appropriate features ophthalmic administration, nanometer size (<200 nm), moderate negative ZP, adequate osmolality pH, colloidal stability biorelevant fluids. Likewise, NEs presented shear thinning behavior, especially convenient instillation. vivo evaluation was performed through either intravitreal injection or topical mice with induced via Nω-nitro-L-arginine-methyl-ester (L-NAME). Both routes reduced morphological alterations demonstrated noticeable antioxidant effect thanks reduction activity/expression NADPH oxidase cornea retina. Thus, represent promising pathologies associated hypertension.

Language: Английский

Citations

3
Magnetic anchoring device assisted-laparoscopic sleeve gastrectomy versus conventional laparoscopic sleeve gastrectomy: A retrospective cohort study DOI Creative Commons
Runkun Liu, Yi-Xian Guo,

Guozhi Yin

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26875 - e26875

Published: Feb. 22, 2024

Bariatric surgeries, including the sleeve gastrectomy, have been recognized as most effectively treatment strategy for severe obesity. Magnetic devices successfully used in bariatric surgeries. Here, we intended to evaluate safety and efficiency of magnetic anchoring device assisted-laparoscopic gastrectomy (MLSG), make a comparison short-term results between conventional laparoscopic (CLSG) MLSG.

Language: Английский

Citations

0
Characterization of human placental fetal vessels in gestational diabetes mellitus DOI Creative Commons

Philine Sophie Carstens,

Heike Brendel,

M. Leyre Villar-Ballesteros

et al.

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Gestational diabetes mellitus is one of the most common complications during pregnancy. Its prevalence rapidly increasing worldwide. leading to an elevated risk for development endothelial dysfunction and cardiovascular diseases both in mother child later life. The underlying pathophysiological mechanisms are not well-understood. Therefore, we aimed characterize function fetal placental vessels from mothers with gestational mellitus. In this study, distinguished between insulin-treated diet-controlled compared them a normoglycemic control group. clinical data confirmed pre-conceptional overweight as factor women group was also characterized by recent family history or Analyses blood serum umbilical cords suggested reduced insulin metabolism Vascular analysis revealed altered substance P-induced vasorelaxation patients insulin-dependent diabetes. Inhibition nitric oxide synthase affected only vessel segments group, but Finally, found significantly decreased P receptor (TACR1) mRNA expression conclusion, provide evidence that different might be responsible versus Only were able detect conversion. This provides novel insights into pathophysiology subtypes

Language: Английский

Citations

0