Cited by The Relationship Between Metal Exposure and HPV Infection: Evidence from Explainable Machine Learning Methods

Cervicovaginal microbiome, high-risk HPV infection and cervical cancer: Mechanisms and therapeutic potential DOI

Roujie Huang,

Zimo Liu,

Tianshu Sun

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 287, P. 127857 - 127857

Published: July 26, 2024

The microbiota in the female genital tract is an intricate assembly of diverse aerobic, anaerobic, and microaerophilic microorganisms, which share space within reproductive engage complex interactions. Microbiome dysbiosis may disrupt symbiotic relationship between host microorganisms play a pivotal role pathogenesis various diseases, including its involvement establishment human papillomavirus (HPV)-associated cervical cancer (CC). Interventions to restore homeostasis (e.g., probiotics) bacterial-vector HPV therapeutic vaccines have been reported be potentially effective clearing infection ameliorating cytological abnormalities. In this review, we place emphasis on elucidating alterations cervical-vaginal as well intratumoral context high-risk (HR-HPV) subsequent progression intraepithelial neoplasia/CC. Furthermore, explore mechanisms by these microbial communities exert potential pathogenic or protective effects, modulating inflammation immune responses, affecting HR-HPV oncogene expression oncoprotein production, regulating oxidative stress deoxyribonucleic acid (DNA) damage, inducing metabolic rewiring. Lastly, summarize latest evidence trials regarding efficacy probiotics, prebiotics probiotic-vector vaccines. This review aims foster deeper understanding infection-related cervix development, further provide theoretical basis for development preventive strategies based modulation.

Language: Английский

Citations

From infection to infertility: a review of the role of human papillomavirus-induced oxidative stress on reproductive health and infertility DOI

Omid Salahi Ardekani, Arash Letafati,

Sepehr Ebrahimi Dehkordi

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 28, 2025

Infertility has emerged as a significant global health concern, affecting nearby 8-12% of couples in reproductive age worldwide. Increasing evidence suggests potential link between human papillomavirus (HPV) and infertility both men women. Some research indicate that HPV can infect various components semen, potentially sperm quality by decreasing motility, viability, increasing DNA fragmentation, all which may contribute to male infertility. The virus attach the equatorial region head, enabling infected transmit oocyte or placenta. Consequently, induces apoptosis trophoblastic cells disrupts their adhesion endometrial cells, raises risk miscarriage. also affect ovarian reserve causing chronic inflammation, impair granulosa cell function lower serum anti-Müllerian hormone (AMH) levels. Besides, HPV-related immune responses producing anti-sperm antibodies (ASAs), cause clumping, reduce motility through cervical mucus, activate complement system damages female tract interfere with sperm-egg interactions. Moreover, infection been linked reduced success rates assisted technologies (ART), disrupting critical processes such acrosome reaction, sperm-oocyte interaction, fusion. One mechanism contributes is oxidative stress (OS). Triggered OS negatively impact damage system, ultimately contributing Despite these associations, precise mechanisms strength relationship remain uncertain. Thus, this review seeks investigate on infertility, particularly its effects OS. A clearer understanding could inform future strategies for addressing

Language: Английский

Citations

Prognostic prediction of oxidative stress related hematological biomarkers in locally advanced cervical cancer patients undergoing chemoradiotherapy DOI

Gang Wu,

Mengxuan Gu,

Jiahao Zhu

et al.

Biomarkers, Journal Year: 2024, Volume and Issue: 29(5), P. 255 - 264

Published: May 20, 2024

This investigation aimed to develop and validate a novel oxidative stress score for prognostic prediction in locally advanced cervical cancer (LACC) patients receiving chemoradiotherapy.

Language: Английский

Citations

Biomolecular Dynamics of Nitric Oxide Metabolites and HIF1α in HPV Infection DOI

Clara Matei, Ilinca Nicolae, Mădălina Irina Mitran

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1172 - 1172

Published: Sept. 18, 2024

Introduction: Viral infections cause oxygen deprivation, leading to hypoxia or anoxia in certain tissues. The limitation of mitochondrial respiration is one the major events during that induces alternative metabolic activities and increased levels biomolecules such as nitric oxide (NO) metabolites. In this study, we aimed investigate role NO metabolites HPV infection. Materials Methods: We included 36 patients with palmoplantar warts healthy subjects performed serum determinations (direct nitrite, total nitrate, 3-nitrotyrosine) HIF1α, a marker hypoxia. Results: found elevated decreased direct nitrite/nitrate ratios versus controls. Additionally, identified statistically significant positive correlations between HIF1α levels, except for 3-nitrotyrosine. Conclusions: Our findings show infection causes alterations metabolism suggest link wart development cellular stress. research could provide new insights comprehensive understanding pathogenesis cutaneous infections.

Language: Английский

Citations

The Relationship Between Metal Exposure and HPV Infection: Evidence from Explainable Machine Learning Methods DOI

Huangyu Hu,

Yue Wu, Jiaqi Liu

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Language: Английский

Citations