Clinopodium gracile Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Upregulating Peroxisome Proliferator-Activated Receptor α and Inhibiting Mitochondrial Oxidative Damage DOI Creative Commons
Ming-Shi Ren,

Jiayue Ren,

Jianmei Zheng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1136 - 1136

Published: Sept. 20, 2024

The most prevalent chronic liver disease, known as metabolic dysfunction-associated steatotic disease (MASLD), is characterized by an excessive accumulation of lipids and oxidative damage. Clinopodium gracile, a natural herbal medicine widely used Chinese folk, has antioxidative, anti-inflammatory, lipid metabolism-regulating effects. Here, we explored the effect C. gracile extract (CGE) on MASLD using palmitic acid (PA)-induced hepatocytes high-fat diet (HFD)-fed mice. In vitro, CGE could promote fatty oxidation inhibit synthesis uptake to reduce regulating PPARα activation. Moreover, reactive oxygen species production maintain mitochondrial homeostasis in PA-induced HepG2 cells. vivo, animal study results indicated that effectively metabolism disorder, stress, upregulate protein HFD-fed Molecular docking also showed active compounds isolated from had low binding energy highly stable with PPARα. summary, these findings reveal may be potential therapeutic candidate for act upregulating suppress

Language: Английский

Effects of Saponins on Lipid Metabolism: The Gut–Liver Axis Plays a Key Role DOI Open Access

Shixi Cao,

Mengqi Liu, Han Yao

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1514 - 1514

Published: May 17, 2024

Unhealthy lifestyles (high-fat diet, smoking, alcohol consumption, too little exercise, etc.) in the current society are prone to cause lipid metabolism disorders affecting health of organism and inducing occurrence diseases. Saponins, as biologically active substances present plants, have lipid-lowering, inflammation-reducing, anti-atherosclerotic effects. Saponins thought be involved regulation body; it suppresses appetite and, thus, reduces energy intake by modulating pro-opiomelanocortin/Cocaine amphetamine regulated transcript (POMC/CART) neurons neuropeptide Y/agouti-related peptide (NPY/AGRP) hypothalamus, control center. directly activate AMP-activated protein kinase (AMPK) signaling pathway related transcriptional regulators such peroxisome-proliferator-activated-receptors (PPAR), CCAAT/enhancer-binding proteins (C/EBP), sterol-regulatory element binding (SREBP) increase fatty acid oxidation inhibit synthesis. It also modulates gut–liver interactions improve regulating gut microbes their metabolites derivatives—short-chain acids (SCFAs), bile (BAs), trimethylamine (TMA), lipopolysaccharide (LPS), et al. This paper reviews positive effects different saponins on disorders, suggesting that axis plays a crucial role improving processes may used therapeutic target provide new strategies for treating disorders.

Language: Английский

Citations

9
Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism DOI Creative Commons
Ziming Yang, Li Zhang, Jinlei Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 495 - 495

Published: April 21, 2024

Litchi pericarp is rich in polyphenols, and demonstrates significant biological activity. This study assessed the therapeutic effects of litchi extract (LPE) on type 2 diabetes mellitus db/db mice. The results showed that LPE ameliorated symptoms glucose metabolism disorder, oxidative stress, inflammatory response, insulin resistance mechanistic studies indicated activates adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) suppresses expression phosphoenolpyruvate carboxykinase (PEPCK), thereby reducing hepatic gluconeogenesis. Additionally, facilitates translocation nuclear factor erythroid2-related (Nrf2) into cell nucleus, initiating transcription antioxidant factors superoxide dismutase (SOD) NAD(P)H: quinone oxidoreductase 1 (NQO1), which alleviate stress reduce damage. Furthermore, blocks kappa-B (NF-κB) subsequent response initiation, inflammation. These findings indicate addresses by activating AMPK energy metabolic pathway regulating Nrf2 NF-κB signaling pathways.

Language: Английский

Citations

5
Natural Products as Modulators of Nrf2 Signaling Pathway: Potential Therapeutic Agents for Metabolic Associated Fatty Liver Disease DOI

Xin-Nan Gu,

Jinyu Zhang, Hao Ouyang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
From nature to nutrition: exploring the synergistic benefits of functional foods and herbal medicines for holistic health DOI Creative Commons

Joyce Mudondo,

Kenneth Happy,

Roggers Gang

et al.

Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)

Published: April 21, 2025

Language: Английский

Citations

0
Liver Disorders and Phytotherapy DOI Creative Commons
Syed Sanober Qadri,

Darakhshan Javaid,

Adfar Reyaz

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102047 - 102047

Published: May 1, 2025

Language: Английский

Citations

0
Clinopodium gracile Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Upregulating Peroxisome Proliferator-Activated Receptor α and Inhibiting Mitochondrial Oxidative Damage DOI Creative Commons
Ming-Shi Ren,

Jiayue Ren,

Jianmei Zheng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1136 - 1136

Published: Sept. 20, 2024

The most prevalent chronic liver disease, known as metabolic dysfunction-associated steatotic disease (MASLD), is characterized by an excessive accumulation of lipids and oxidative damage. Clinopodium gracile, a natural herbal medicine widely used Chinese folk, has antioxidative, anti-inflammatory, lipid metabolism-regulating effects. Here, we explored the effect C. gracile extract (CGE) on MASLD using palmitic acid (PA)-induced hepatocytes high-fat diet (HFD)-fed mice. In vitro, CGE could promote fatty oxidation inhibit synthesis uptake to reduce regulating PPARα activation. Moreover, reactive oxygen species production maintain mitochondrial homeostasis in PA-induced HepG2 cells. vivo, animal study results indicated that effectively metabolism disorder, stress, upregulate protein HFD-fed Molecular docking also showed active compounds isolated from had low binding energy highly stable with PPARα. summary, these findings reveal may be potential therapeutic candidate for act upregulating suppress

Language: Английский

Citations

0