Journal of Cardiothoracic Surgery,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: April 16, 2025
Leonurus
japonicus
Houtt.
(LJH)
has
multiple
pharmacological
effects.
To
investigate
the
potential
mechanism
of
LJH
in
treatment
myocardial
ischemia-reperfusion
injury
(MIRI)
using
network
pharmacology,
molecular
docking
technology,
and
vitro
experiments.
Herbs
for
ischemic
heart
disease
were
identified
with
help
herb-disease
databases.
The
TCMSP
database
was
used
to
find
targets
LJH.
Disease
MIRI
Disgenet,
Genecard,
Alliance
Genome
Resources
common
obtained
VENN
diagram,
analyzed
by
GO
function
KEEG
pathway
enrichment
predict
action
treating
MIRI.
With
STRING
Cytoscape
software,
we
constructed
a
visual
protein-protein
interaction
(PPI)
model
screen
core
then
docked
corresponding
ligand
molecules.
AC16
cells
simulate
glucose-oxygen
deprivation,
apoptosis
detected
Annexin
V-FITC/PI
double
staining;
protein
expression
Western
blot.
one
herbal
remedies
disease.
had
247
26
These
enriched
TNF
signaling
NF-kappa
B
pathway,
screened
PPI
results
included
TNF,
VCAM1,
MMP9.
Molecular
showed
that
compounds
well
target
proteins.
In
experiments
could
inhibit
elevation
MMP9
after
MIRI,
reduce
apoptosis,
inflammation.
mainly
related
activation
regulation
expression.
Journal of Cardiothoracic Surgery,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 15, 2025
miRNA,
circRNA,
and
lncRNA
play
crucial
roles
in
the
pathogenesis
progression
of
myocardial
ischemia-reperfusion
injury
(MI/RI).
This
study
aims
to
provide
valuable
insights
into
lncRNA,
MI/RI
from
a
bibliometric
standpoint,
with
goal
fostering
further
advancements
this
area.
The
relevant
literature
field
was
retrieved
Science
Citation
Index
Expanded
(SCI-E)
database
within
Web
Science.
"Analyze
Results"
"Citation
Report"
functions
WOS
were
utilized
compile
annual
publication
citation
counts
field.
Microsoft
Office
Excel
2019
used
organize
visualize
data.
Furthermore,
visualization
analyses
countries/regions,
institutions,
authors,
keywords,
references
conducted
using
software
CiteSpace.
A
total
858
publications
included
for
analysis
published
across
297
journals,
Molecular
Medicine
Reports
contributing
highest
number
publications.
Researchers
45
countries
participated
studies
field,
those
China
most
research
hotspots
primarily
focus
on
three
areas:
role
MI/RI,
their
potential
as
therapeutic
targets,
biomarkers.
Among
these,
circular
RNA,
therapy
target,
inflammatory
response,
cardiomyocyte
ferroptosis
are
likely
emerge
emerging
trends
overall
development
is
rise.
compilation
area
may
researchers
more
assistance
selecting
directions,
ultimately
benefiting
patients.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 5, 2025
Background
The
Geriatric
Nutritional
Risk
Index
(GNRI)
is
a
clinical
indicator
for
evaluating
the
nutritional
status
of
patients,
but
its
role
in
short-term
prognosis
patients
with
acute
myocardial
infarction
still
not
fully
understood.
This
study
aims
to
explore
correlation
between
GNRI
and
overall
mortality
within
30
days
365
those
(AMI).
Methods
A
retrospective
analysis
was
performed
utilizing
Medical
Information
Mart
Intensive
Care
IV
(MIMIC-IV)
database.
included
895
diagnosed
AMI
identified
through
ICD9
ICD10
codes
(410,
I21,
I23)
who
were
hospitalized
first
time
due
AMI.
Subjects
classified
into
four
groups
according
GNRI:
high
(GNRI
<82,
n
=
110),
moderate
(82
≤
<92,
205),
low
(92
<98,
225),
no
risk
≥98,
355).
Restricted
cubic
splines
(RCS)
threshold
effect
analyses
applied
non-linear
relationship
mortality.
Subgroup
conducted
based
on
gender,
hypertension,
diabetes,
stroke,
hyperlipidemia,
chronic
obstructive
pulmonary
disease,
age.
mediation
investigate
impact
lymphocytes
association
Results
In
an
sample
elevated
correlated
reduced
30-day
(HR
0.937,
95%
CI:
0.917–0.957,
p
<
0.001)
365-day
0.923–0.950,
0.001).
trend
categories
indicated
significant
decline
associated
rising
(P
<0.001).
validated
consistency
such
results
throughout
diverse
patient
characteristics.
significantly
mediated
(ACME:
0.022,
0.003–0.180,
landmark
at
20
after
admission
further
demonstrated
during
different
phases
recovery.
Conclusion
highlights
prognostic
value
predicting
long-term
emphasizing
significance
inflammatory
indicators
therapy
assessment
these
individuals.
Cardiovascular Therapeutics,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
The
NACHT,
leucine-rich
repeat,
and
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome
plays
an
essential
role
in
myocardial
infarction
(MI)
development.
Up
to
now,
no
bibliometric
analyses
of
NLRP3
MI
have
been
performed.
Publications
related
from
1
January
2013
20
August
2024
were
extracted
the
Web
Science
Core
Collection
(WoSCC).
HistCite
Pro,
CiteSpace,
VOSviewer,
Scimago
Graphica,
online
analysis
program
used
for
visualization.
impact
publications
was
assessed
using
total
global
citation
score
(TGCS).
A
324
articles
(284
40
reviews)
included.
China
has
published
most
this
field,
followed
by
United
States.
Harbin
Medical
University
leading
institution
research
MI.
Professor
Abbate
A.
States
made
significant
achievements
field.
International
Immunopharmacology
active
journal
Journal
Cardiovascular
Pharmacology
cited
journal.
This
study
systematically
summarizes
results
over
past
12
years.
ischemia-reperfusion
injury
(MIRI)
will
become
a
hot
topic,
translational
on
inhibitors
MIRI
benefit
greater
number
patients.
