Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: Feb. 28, 2025

ABSTRACT Allium macrostemon Bge. (AM) is a widely utilized culinary spice recognized for its numerous health‐promoting properties. Aging‐related cognitive impairment (ARCI) represents significant global health concern during the aging process. However, potential of AM to attenuate ARCI has not been investigated. This work aims reveal effects and mechanisms water extraction (WEAM) in alleviating ARCI, with particular emphasis on BDNF/TrkB signaling pathway. The findings showed enhancement memory function reduction hippocampal neuronal damage mice following treatment WEAM, manifested by an increased spontaneous alternation rate Y‐maze, prolonged step‐through latency, decreased number errors PAT test, shortened escape latency platform swimming time crossing times MWM test. Additionally, WEAM reduced oxidative stress, elevated expression proteins related synaptic plasticity (SYN PSD95), activated pathway D‐galactose‐induced mice. To elucidate mechanism which alleviates both TrkB activator (7,8‐DHF) inhibitor (ANA‐12) were employed. results demonstrated that potentiated 7,8‐DHF diminished ANA‐12. Finally, 11 chemical compositions analyzed quantified using HPLC‐MS/MS, including macrostemonoside, sarsasapogenin, diosgenin, timosaponin AIII, N‐p‐trans‐coumaroyltyramine, guanosine, adenosine, phenylalanine, adenine, arginine, valine. These suggest may serve as promising mitigating promoting pathway, thereby enhancing plasticity.

Language: Английский

Neonatal febrile seizures: Dimethyl itaconate’s role in behavioral recovery and glutathione enzyme modulation in adult rats

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318430 - e0318430

Published: March 25, 2025

Febrile seizures are common in children and can lead to neurological deficits like motor impairments, memory problems, cognitive decline. Research on dimethyl itaconate aims mitigate these effects improve the quality of life for affected people. By exploring its potential as a protective agent against oxidative stress during seizures, this study adult male rats measures activity key enzymes related behavioral performance. Pregnant were divided into control, sham, DMI, febrile seizure, DMI + seizure groups. Seizure severity was evaluated through threshold frequency measurements, while memory, function, balance assessed using shuttle box, rotarod, open field, wire hanging tests. After that, hippocampus tissue removed from brain levels MDA, SOD, GSH, TAC, GR, GPx, catalase measured biochemical methods. Results show that raised reduced tonic-clonic seizures. The group also showed improved movement, compared (p < 0.05 all cases). Overall, decreased outcomes fever-affected rats.

Language: Английский

Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9943 - 9943

Published: Sept. 14, 2024

In previous studies, using transcriptomic analysis, we observed higher levels of aryl hydrocarbon receptor (AHR) gene expression in the peripheral blood cells centenarians compared to octogenarians. This suggests potential significance this maintaining physiological balance and promoting healthy aging, possibly linked its critical role detoxifying xenobiotics. our current study, confirmed that AHR is indeed centenarians. We employed

Language: Английский