Ferrous sulfate and lipopolysaccharide co-exposure induce neuroinflammation, neurobehavioral motor deficits, neurodegenerative and histopathological biomarkers relevant to Parkinson’s disease-like symptoms in Wistar rats

BioMetals, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

---

The association between oxidative balance scores and all-cause mortality and cancer-specific mortality in cancer survivors: a retrospective cohort study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 21, 2025

Background Numerous studies have established that oxidative stress significantly affects the long-term survival of cancer survivors. However, there is currently no comprehensive measure to assess levels in these individuals associates with all-cause, cause-specific, and cardiovascular disease (CVD) mortality. This study aims investigate relationship between Oxidative Balance Score (OBS) American survivors their risks cancer-specific, CVD Methods research included from National Health Nutrition Examination Survey dataset covering 2001–2018 cycles, incorporating appropriate weighting. The OBS, a composite index reflecting status, was constructed based on 16 dietary components 4 lifestyle factors, higher OBS indicating greater antioxidant capacity. Using multivariable Cox regression, restricted cubic splines analysis (RCS), subgroup analysis, sensitivity we examined associations mortality, including further stratified analyses for specific types populations. Results enrolled 2,131 eligible survivors, median follow-up 115 months 673 recorded deaths. Weighted regression results showed each unit increase associated 3% decrease all-cause mortality (Hazard Ratios [HR]: 0.97, 95% Confidence interval [CI]: 0.95, 0.99, p = 0.006). Among participants, those highest quartile (Q4) had 40% lower risk compared lowest (Q1) (HR: 0.60, CI: 0.41, 0.88, 0.009). A similar significant association found cancer-specific while noted RCS highlighted linear negative association. Subgroup indicated stronger among breast patients, without stroke or arthritis individuals. Sensitivity confirmed robustness findings. Conclusion reveals both

Language: Английский

---

Iron Metabolism in the Recovery Phase of Critical Illness

Published: May 7, 2024

Iron is an essential nutrient for humans and microbes, such as bacteria. deficiency occurs commonly in critically ill patients, but iron replacement therapy not considered during the acute phase of critical illness, since it increases availability invading microbes oxidative stress. However, persistent recovery harmful with potential adverse outcomes cognitive dysfunction, fatigue cardiopulmonary dysfunction. Therefore, important to treat timely efficiently. This article reviews current knowledge about iron-related biomarkers patients provides possible criteria guide decision-making supplementation illness.

Language: Английский

---

Iron Metabolism in the Recovery Phase of Critical Illness with a Focus on Sepsis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7004 - 7004

Published: June 26, 2024

Iron is an essential nutrient for humans and microbes, such as bacteria. deficiency commonly occurs in critically ill patients, but supplementary iron therapy not considered during the acute phase of critical illness since it increases availability invading microbes oxidative stress. However, persistent recovery harmful has potential adverse outcomes cognitive dysfunction, fatigue, cardiopulmonary dysfunction. Therefore, important to treat quickly efficiently. This article reviews current knowledge about iron-related biomarkers with a focus on patients sepsis, provides possible criteria guide decision-making supplementation those patients.

Language: Английский

---

Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2024, Volume and Issue: 2(3), P. 182 - 195

Published: Sept. 1, 2024

The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, heterogeneity in disease onset mechanisms and specific brain regions affected complicates understanding diverse clinical manifestations individual NDDs. Dementia, hallmark symptom across various NDDs, serves as multifaceted denominator, contributing to these disorders. There is compelling hypothesis that therapeutic strategies capable mitigating protein disrupting ongoing pathogenic processes may slow or even halt progression. Recent research has linked disease-associated microglia their transition into senescent state-characterized by irreversible cell cycle arrest-in aging populations Although are consistently observed few studies have utilized animal models explore role pathology. Emerging evidence from experimental rat suggests exhibit characteristics senescence, indicating deeper exploration microglial senescence could enhance our NDD pathogenesis reveal novel targets. This review underscores importance investigating its potential contributions pathophysiology including Alzheimer's disease, Parkinson's Huntington's amyotrophic lateral sclerosis. Additionally, it highlights targeting through iron chelation senolytic therapies innovative approaches for treating age-related

Language: Английский

---

Psychological Burden among Pediatric Thalassemia Major Patients in Indonesia: A Review

Thalassemia Reports, Journal Year: 2024, Volume and Issue: 14(2), P. 33 - 43

Published: May 14, 2024

Thalassemia a common hereditary blood disorder resulting in anemia. It is an important public health problem, with high prevalence Southeast Asia and Mediterranean countries, preventable through screening programs. However, due to its chronic nature, permanent physical changes, troublesome complications, lifelong treatment, pediatric patients thalassemia major are more prone mental disorders cognitive impairment. Internalizing externalizing problems higher thalassemia. Children β-thalassemia exhibit lower IQ scores than healthy children. Neurophysiology neuroimaging examinations have shown abnormal results children Co-morbidity increases the mortality, morbidity, total healthcare costs of Therefore, routine evaluation recommended accommodate early detection prompt treatment disorders. A multidisciplinary approach for families should be delivered by providing appropriate medical care, psychosocial support, good transition care improve survival well-being, assist social integration daily functioning, cope stress disease.

Language: Английский

---

Effect of moderate red meat intake compared to plant-based meat alternative on psychological well-being: A 10-week cluster randomized intervention in healthy young adults

Current Developments in Nutrition, Journal Year: 2024, Volume and Issue: 9(1), P. 104507 - 104507

Published: Nov. 16, 2024

A healthy diet has been proposed to support good mental health, but the addition of either red meat or alternatives is nuanced.

Language: Английский

---