Depression and Accelerated Aging: The Eveningness Chronotype and Low Adherence to the Mediterranean Diet Are Associated with Depressive Symptoms in Older Subjects DOI Open Access
José V. Sorlí,

Edurne de la Cámara,

Rebeca Fernández-Carrión

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 104 - 104

Published: Dec. 30, 2024

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed association between epigenetic biomarkers aging depressive symptoms. Similarly, limited research has examined joint effects adherence to Mediterranean diet (MedDiet) chronotype on symptoms, accounting for sex differences. Therefore, these are objectives our investigation a population at high cardiovascular risk. Methods: We 465 older subjects (aged 55–75) with metabolic syndrome assessed symptoms by Beck Inventory (BDI-II). MedDiet was measured 17-item score, Morningness–Eveningness Questionnaire (MEQ). Blood DNA methylation analyzed, epigenomic age acceleration were determined. focused Dunedin Pace Aging Computed from Epigenome (DunedinPACE). fitted multivariable models interaction terms. Results: Prevalence depression statistically higher women (p < 0.001). strongly inversely associated whole 0.01), while MEQ score 0.05). In analysis, both remained BDI-II 0.05), showing additive effects. No observed. women, significantly faster (measured DunedinPACE biomarker). This significant even after adjustment chronotype. Conclusions: syndrome, eveningness greater could potentially counteract Women showed stronger associations, importantly, we reported first time this that accelerated aging.

Language: Английский

Association of healthy and unhealthy plant-based diets with telomere length DOI
Xiude Li, Meiling Li, Jing Cheng

et al.

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(8), P. 1694 - 1701

Published: June 8, 2024

Language: Английский

Citations

3
Is exposure to pesticides associated with biological aging? A systematic review and meta-analysis DOI Open Access
Shanshan Zuo,

Vidhya Sasitharan,

Gian Luca Di Tanna

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Objective Exposure to pesticides is a risk factor for various diseases, yet its association with biological aging remains unclear. We aimed systematically investigate the relationship between pesticide exposure and aging. Methods PubMed, Embase Web of Science were searched from inception August 2023. Observational studies investigating biomarkers included. Three-level random-effect meta-analysis was used synthesize data. Risk bias assessed by Newcastle-Ottawa Scale. Results Twenty evaluating associations in 10,368 individuals Sixteen reported telomere length four epigenetic clocks. Meta-analysis showed no statistically significant Hannum clock (pooled β = 0.27; 95%CI: -0.25, 0.79), or Hedges’g -0.46; -1.10, 0.19). However, opposite direction effect two outcomes an indication possible accelerated After removal influential sizes low-quality studies, shorter found higher-exposed populations. Conclusion The existing evidence limited due scarcity on clocks substantial heterogeneity across examining length. High-quality incorporating more aging, focusing active chemical ingredients accounting potential confounders are needed enhance our understanding impact

Language: Английский

Citations

0
Depression and Accelerated Aging: The Eveningness Chronotype and Low Adherence to the Mediterranean Diet Are Associated with Depressive Symptoms in Older Subjects DOI Open Access
José V. Sorlí,

Edurne de la Cámara,

Rebeca Fernández-Carrión

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 104 - 104

Published: Dec. 30, 2024

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed association between epigenetic biomarkers aging depressive symptoms. Similarly, limited research has examined joint effects adherence to Mediterranean diet (MedDiet) chronotype on symptoms, accounting for sex differences. Therefore, these are objectives our investigation a population at high cardiovascular risk. Methods: We 465 older subjects (aged 55–75) with metabolic syndrome assessed symptoms by Beck Inventory (BDI-II). MedDiet was measured 17-item score, Morningness–Eveningness Questionnaire (MEQ). Blood DNA methylation analyzed, epigenomic age acceleration were determined. focused Dunedin Pace Aging Computed from Epigenome (DunedinPACE). fitted multivariable models interaction terms. Results: Prevalence depression statistically higher women (p < 0.001). strongly inversely associated whole 0.01), while MEQ score 0.05). In analysis, both remained BDI-II 0.05), showing additive effects. No observed. women, significantly faster (measured DunedinPACE biomarker). This significant even after adjustment chronotype. Conclusions: syndrome, eveningness greater could potentially counteract Women showed stronger associations, importantly, we reported first time this that accelerated aging.

Language: Английский

Citations

0