Dietary polyphenols for tumor therapy: bioactivities, nano-therapeutic systems and delivery strategies

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review provides a comprehensive evaluation of the anti-tumor bioactivities and delivery strategies dietary polyphenols, as well their application in development nano-therapeutic systems for tumor.

Language: Английский

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Phytochemical baicalin potentially inhibits Bcl-2 and VEGF: an in silico approach

Frontiers in Bioinformatics, Journal Year: 2025, Volume and Issue: 5

Published: Feb. 19, 2025

The rising prevalence of cancer cells exhibits uncontrolled growth and invasive aggressive properties, leading to metastasis, which poses a significant challenge for global health. Central development are proteins such as NF-kB, p53, VEGF, BAX/Bcl-2, play important roles in angiogenesis, cell apoptosis regulation, tumor growth. This silico study evaluates the activity six different natural well novel therapeutic strategies against cancer. Using computational approach, i.e., virtual screening, molecular docking, dynamics (MD) simulations, binding affinities interactions selected phytochemicals with cancer-specific were analyzed. Key criteria selection included affinity, stability, pharmacokinetic toxicological properties. Post-selection, ligand-protein further examined through MD simulations conducted using Desmond-Maestro 2020-4 on Linux-based HP Z2 workstation, providing an insight into conformational changes stability inhibitor-protein complexes. was complemented by ADMET predictions assess pharmacokinetics profiles. Our findings reveal that out phytochemicals, baicalin exhibited most promising results, docking scores -9.2 kcal/mol -9.0 Bcl-2 VEGF receptors, respectively. simulation (100 ns) confirmed baicalin-protein interactions, supported hydrophobic intermolecular hydrogen bonds. RMSD RMSF values exhibit acceptable minimum (3.5-6 Å) BAX/Bcl-2. highlights potential baicalin, phytochemical known anti-cancerous, anti-apoptotic, anti-proliferative candidate treatment. Further exploration validation its inhibitory mechanisms could open avenue approaches oncology.

Language: Английский

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Virtual perspectives of sanguinarine on cancer prevention and treatment through molecular dynamic study

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 25, 2025

Language: Английский

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Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

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G-quadruplex in cancer energy metabolism: A potential therapeutic target

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130810 - 130810

Published: April 1, 2025

Language: Английский

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Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3736 - 3762

Published: May 22, 2024

Recently, malignant neoplasms have growingly caused human morbidity and mortality. Head neck cancer (HNC) constitutes a substantial group of malignancies occurring in various anatomical regions the head neck, including lips, mouth, throat, larynx, nose, sinuses, oropharynx, hypopharynx, nasopharynx, salivary glands. The present study addresses phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target rapamycin (mTOR) pathway as possible therapeutic therapy. Finding new multitargeting agents capable modulating PI3K/Akt/mTOR cross-linked mediators could be viewed an effective strategy combating HNC. Recent studies introduced phytochemicals rich sources for finding developing agents. Phytochemicals exhibited immense anticancer effects, targeting different stages HNC through modulation several signaling pathways. Moreover, phenolic/polyphenolic compounds, alkaloids, terpenes/terpenoids, other secondary metabolites demonstrated promising activities because their diverse pharmacological biological properties like antiproliferative, antineoplastic, antioxidant, anti-inflammatory activities. current review is mainly focused on strategies passing

Language: Английский

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Development and Characterization of Curcumin-Loaded TPGS/F127/P123 Polymeric Micelles as a Potential Therapy for Colorectal Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7577 - 7577

Published: July 10, 2024

Colorectal cancer (CRC) is the third most prominent worldwide, and second leading cause of death. Poor outcomes limitations current treatments fuel search for new therapeutic options. Curcumin (CUR) often presented as a safer alternative treatment with staggering number molecular targets involved in tumor initiation, promotion, progression. Despite being promising, its potential hindered due to hydrophobic nature. Hence, ongoing development optimal delivery strategies based on nanotechnology, such polymeric micelles (PMs), overcome issues CUR solubilization cells. In this sense, study aimed optimize stability CUR-loaded P123:F127:TPGS PMs (PFT:CUR) thin-film approach evaluate their CRC. Overall, results revealed that solubility was improved when room temperature used hydrate film. The PFT–CUR hydrated at presents an average hydrodynamic diameter 15.9 ± 0.3 nm polydispersity index (PDI) 0.251 0.103 zeta −1.5 1.9 mV, 35.083 1.144 encapsulation efficiency (EE%) 3.217 0.091 drug loading (DL%) were observed. To ensure optimized nanosystems, different lyophilization protocols tested, use 1% glycine (GLY) promising protocol. Regarding critical micellar concentration (CMC), it shown cryoprotectant process could impact it, increase from 0.064 mg/mL 0.119 mg/mL. vitro showed greater cytotoxic effects encapsulated compared free form, yet further analysis heightened cytotoxicity be attributed system itself. challenges, developed PM shows effective agent Nonetheless, must undergo refinements enhance entrapment well improve overall stability.

Language: Английский

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20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1349 - 1349

Published: Nov. 2, 2024

20-Hydroxyecdysone (20E) is an arthropod steroid hormone that possesses a number of beneficial pharmacological activities in humans, including anabolic, antioxidant, hypoglycemic, cardioprotective, hepatoprotective, neuroprotective, and antineoplastic properties, etc. While several studies have explored the anabolic activity 20E muscle cells, they concentrated on its effects myofibril size, protein biosynthesis intensity, myostatin expression, without assessing energy metabolism. In this research, we demonstrated boosts both catabolism anabolism, coupling energy-producing biosynthetic metabolic processes mouse myoblasts fibroblasts same way. Using transcriptomic approach, identified 20E-mediated up-regulation genes involved different processes. Further experiments revealed increased levels enzymes glycolysis one-carbon It also uptake glucose, glycolysis, respiration, production ATP, global fibroblasts. This phenomenon involves PI3K/AKT/mTOR signaling pathway. Taken together, observed 20E-dependent upregulation metabolism may be main reason for 20E's well-known activity.

Language: Английский

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Ginsenoside Rh2 Regulates the Calcium/ROS/CK1α/MLKL Pathway to Promote Premature Eryptosis and Hemolysis in Red Blood Cells

Toxicologic Pathology, Journal Year: 2024, Volume and Issue: 52(5), P. 284 - 294

Published: July 1, 2024

Ginsenoside Rh2 (GRh2) exhibits significant potential as an anticancer agent; however, progress in developing chemotherapeutic drugs is impeded by their toxicity toward off-target tissues. Specifically, anemia caused chemotherapy a debilitating side effect and can be red blood cell (RBC) hemolysis eryptosis. Cells were exposed to GRh2 the antitumor range hemolytic eryptotic markers examined under different experimental conditions using photometric cytofluorimetric methods. Ca

Language: Английский

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20-Hydroxyecdysone Suppresses the Expression of Genes Encoding Enzymes of β-Oxidation of Fatty Acids in Non-Small-Cell Lung Cancer Cells

Cell and Tissue Biology, Journal Year: 2024, Volume and Issue: 18(6), P. 663 - 670

Published: Nov. 28, 2024

Language: Английский

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