Oxidative Stress Indicated by Nuclear Transcription Factor Nrf2 and Glutathione Status in the Blood of Young Children with Autism Spectrum Disorder: Pilot Study

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 320 - 320

Published: March 6, 2025

This pilot study investigated the relationship between nuclear transcription factor Nrf2 and glutathione homeostasis in children with autism spectrum disorder (ASD), addressing role of oxidative stress ASD pathophysiology. Oxidative stress, characterized by an imbalance reactive oxygen species antioxidant defenses, has been implicated may contribute to neuroinflammation mitochondrial dysfunction. Nrf2, a key regulator response, influences synthesis recycling, making it critical for cellular redox balance. included 23 21 neurotypical healthy controls, measured levels Keap1 (Kelch-like ECH-associated protein 1), reduced (GSH), oxidized (GSSG), reductase (GR), peroxidase (GPx3) blood samples. Our reveals altered defense disorder, as evidenced Keap1, GSH, GR, along elevated GSSG lower GSH/GSSG ratio. These findings indicate increased burden this population. Additionally, observed positive correlation GR suggests important maintaining homeostasis. results underscore potential involvement emphasize need further research into targeted therapeutic approaches address imbalance.

Language: Английский

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Telomere Length and Oxidative Damage in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 23, 2025

Background: Autism spectrum disorder (ASD) has been reported to confer an increased risk of natural premature death. Telomere erosion caused by oxidative stress is a common consequence in age-related diseases. However, whether telomere length (TL) and indicators are significantly changed ASD patients compared with controls remains controversial. The aim this study was determine the associations TL performing meta-analysis all published evidence. Methods: PubMed Embase databases were searched for articles up April, 2024. effect size expressed as standardized mean difference (SMD) 95% confidence interval (CI) via Stata 15.0 software. Results: Thirty-nine studies included. Pooled results showed that controls, children adolescents associated shorter (SMD = –0.48; CI –0.66– –0.29; p < 0.001; particularly males), lower total antioxidant capacity (TAC: SMD –1.15; –2.01– –0.30; 0.008), higher DNA (8-hydroxy-2′-deoxyguanosine, 8-OHdG: 0.63; 0.03–1.23; 0.039), lipid (hexanolyl-lysine, HEL: 0.37; 0.13–0.62; 0.003), protein (3-nitrotyrosine, 3-NT: 0.86; 0.21–1.51; 0.01; dityrosine, DT: 0.66; 0.521–0.80; 0.01) damage. There no significant differences between 8-isoprostane index after publication bias correction, N-formylkynurenine during overall meta-analysis. Conclusions: TL, 8-OHdG, TAC, HEL, 3-NT, DT represent potential biomarkers prediction adolescents.

Language: Английский

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Melatonin Pre-Treatment Protects Erythrocytes Against Subsequent Oxidative Damage

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 658 - 658

Published: Feb. 1, 2025

Research on the effects of melatonin erythrocyte deformability has yielded mixed results. While some studies reported improvements, others found no effect, and a few even noted deterioration in deformability. Moreover, impact may vary between healthy erythrocytes those subjected to oxidative stress. This study investigated dose-dependent under baseline conditions stress, using both pre- post-stress incubation protocols. Oxidative damage was induced with tert-butyl hydroperoxide (TBHP), its extent assessed via dichlorofluorescein fluorescence. Erythrocyte measured ektacytometry, osmotic resistance through hemolytic assays. The results showed that TBHP led decline resistance. treatment had observable effect intact erythrocytes, it enhanced oxidatively damaged when administered before stress induced. However, beneficial not evident applied after damage. Additionally, ability resist hypotonic environment. In conclusion, this supports notion antioxidant properties can improve functional status, as reflected by deformability, but Notably, observed only were exposed incubation, cells.

Language: Английский

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Examining Erythrocytes as Potential Blood Biomarkers for Autism Spectrum Disorder: Their Relationship to Symptom Severity and Adaptive Behavior

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2619 - 2619

Published: Nov. 15, 2024

Multiple research teams have documented various abnormalities in erythrocyte properties children with autism spectrum disorder (ASD) compared neurotypical individuals. Reduced deformability, a crucial factor for microcirculation and oxygen delivery, may affect brain function. Other key factors like nitric oxide (NO) Na,K-ATPase-regulated cation transport also play roles both deformability ASD, suggesting possible relationship between parameters severity. Thus, this study aims to describe these associations, exploring as potential biomarkers ASD.

Language: Английский

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