Sulforaphane Exposure Prevents Cadmium-Induced Toxicity and Mitochondrial Dysfunction in the Nematode Caenorhabditis elegans by Regulating the Insulin/Insulin-like Growth Factor Signaling (IIS) Pathway

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 584 - 584

Published: May 9, 2024

Cadmium (Cd) is a heavy metal that highly toxic to humans and animals. Its adverse effects have been widely associated with mitochondrial alterations. However, there are not many treatments target mitochondria. This study aimed evaluate the impact of sulforaphane (SFN) pre-exposure against cadmium chloride (CdCl2)-induced toxicity alterations in nematode Caenorhabditis elegans (C. elegans), by exploring role insulin/insulin-like growth factor signaling pathway (IIS). The results revealed prior exposure SFN protected CdCl2-induced mortality increased lifespan, body length, mobility while reducing lipofuscin levels. Furthermore, prevented increasing membrane potential (Δψm) restoring oxygen consumption rate, thereby decreasing reactive species (ROS) production. improvement function was mass involvement daf-16 skn-1c genes IIS pathway. In conclusion, before CdCl2 mitigates alterations, possibly mass, which may be related regulation These discoveries open new possibilities for developing therapies reduce damage caused Cd oxidative stress biological systems, highlighting antioxidants action as promising tools.

Language: Английский

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IDENTIFICATION OF VISCERAL ORGAN CELLS THAT ARE RESISTANT TO LIPOFUSCINOGENESIS

Современные проблемы науки и образования (Modern Problems of Science and Education), Journal Year: 2024, Volume and Issue: №3 2024, P. 85 - 85

Published: Jan. 1, 2024

ВЫЯВЛЕНИЕ КЛЕТОК ВИСЦЕРАЛЬНЫХ ОРГАНОВ, ГИПОРЕЗИСТЕНТНЫХ К ЛИПОФУСЦИНОГЕНЕЗУТризно М

Language: Русский

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Small molecule SIRT1 activators counteract oxidative stress-induced inflammasome activation and nucleolar stress in retinal degeneration

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113167 - 113167

Published: Sept. 19, 2024

Language: Английский

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Prevention of Sunlight-Induced Cell Damage by Selective Blue-Violet-Light-Filtering Lenses in A2E-Loaded Retinal Pigment Epithelial Cells

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1195 - 1195

Published: Oct. 1, 2024

Blue light accelerates retinal aging. Previous studies have indicated that wavelengths between 400 and 455 nm are most harmful to aging pigment epithelia (RPE). This study explored whether filtering these can protect cells exposed broad sunlight. Primary porcine RPE loaded with 20 µM A2E were emulated sunlight filtered through eye media at 1.8 mW/cm

Language: Английский

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Gallic Acid-Encapsulated PAMAM Dendrimers as an Antioxidant Delivery System for Controlled Release and Reduced Cytotoxicity against ARPE-19 Cells

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Poly(amidoamine) (PAMAM) dendrimers have gained significant attention in various research fields, particularly medicinal compound delivery. Their versatility lies their ability to conjugate with functional molecules on surfaces and encapsulate small molecules, making them suitable for diverse applications. Gallic acid is a potent antioxidant that has garnered considerable interest recent years. Our aims investigate if the gallic acid-encapsulated PAMAM dendrimer generations 4 (G4(OH)-Ga) 5 (G5(OH)-Ga) could enhance radical scavenging, which potentially slow down progression of age-related macular degeneration (AMD). Encapsulation feasible alternative prevent its degradation toxicity.

Language: Английский

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