Cited by Flavonoids from Rhododendron nivale Hook. f ameliorate alcohol-associated liver disease via activating the PPARα signaling pathway

High-frequency ultrasound-assisted drug delivery of chia, cress, and flax conjugated hematite iron oxide nanoparticle for sono-photodynamic lung cancer treatment in vitro and in vivo DOI

Samir Ali Abd El-Kaream,

Doha Farhat Mohamed Zedan,

Hagar Mohamed Mohamed

et al.

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 17, 2024

Abstract Background Sono-photodynamic therapy (SPDT), which combines photodynamic (PDT) and sonodynamic (SDT) therapies with sensitizers, offers new avenues for cancer treatment. Even though sensitizers SPDT have been synthesized great success, few of them are effectively used. The limited tumor-targeting specificity, inability to transport the deeply intratumorally, deteriorating tumor microenvironment limit their anti-tumor effectiveness. current study was carried out aiming at high-frequency ultrasound-assisted drug delivery chia, cress flax conjugated hematite iron oxide nanoparticles (CCF–HIONP) photothermal–photodynamic lung (LCA) treatment in vitro vivo as activated up-to-date modality. Materials methods conducted on human LCA cells (A-549) protocol application groups Swiss albino mice treated benzo[a]pyrene only were not received any inducing LCA, after induction began, daily CCF–HIONP HIFU–SPDT sensitizer or without exposure laser (IRL) ultrasound (HIFU–US) a combination and/or 3 min 2 weeks. Results Revealed that HIONP can be employed effective CCF system directly targets cells. In addition, is promising HIFU–SPS when combined very LCA–A549 (cell viability decreased dose-dependent basis, cell cycle progression G0/G1 slowed down, death induced evidenced by an increase population Pre-G cells, early late apoptosis necrosis, autophagic death) LCA-induce (decreased oxidative stress (MDA), ameliorated enzymatic non-enzymatic antioxidants (SOD, GR, GPx, GST, CAT, GSH, TAC) well renal (urea, creatinine) hepatic (ALT, AST) functions, antiproliferative genes (caspase 3,9, p53, Bax, TNFalpha), suppressed antiapoptotic antiangiogenic (Bcl2,VEGF respectively) reducing growth tumors even leading death. This process could attributed photochemical sono-chemical activation mechanism HIFU–SPDT. Conclusions results indicate has promise innovative, selective localized

Language: Английский

Citations

Phytochemicals of Vitis vinifera L. var. King Ruby protect mice from benzo(a)pyrene-induced lung injury DOI

Gehad S. Ahmedy,

Hend Mostafa Selim, Mona El‐Aasr

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 6, 2025

Abstract The world’s concern about smoking hazards, chronic obstructive pulmonary disease (COPD) and lung cancer was the motivation to investigate plants as a source of new drugs with protective effect. phytochemical profile Vitis vinifera L. var. King Ruby leaves methanol extract (VLME) tentatively recognized by liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS). Fifty-two forty-seven compounds were identified negative positive ESI modes, respectively. Taraxerol (1) , β- sitosterol (2) daucosterol (3) quercetin-3- O - β -D-glucuronoide-6″-methyl ester (4) isoquercetin (5) isolated from VLME. sulforhodamine B (SRB) assay different fractions against A-549 cell line revealed that methylene chloride fraction (MCF) had lowest viability at 300 µg/mL (4.54 ± 0.19%). Mice 10 groups ( n = 6) treated follows: Group I (negative control group), group II (disease control, mice received B(a)P 125 mg/kg, orally), III-V (mice 100, 200, mg/kg VLME, followed B(a)P), VI only VLME), VII-XI MCF, X MCF). On seventh day, all single oral dose body, except . In vivo studies showed VLME MCF (300 body weight) effectively mitigated benzo(a)pyrene-induced injuries in mice. anti-inflammatory effects confirmed downregulation cyclooxygenase-2 (COX-2) CD34, alongside reduced nuclear factor-kappa (NF-κB) expression. Antioxidant activity indicated decreased malondialdehyde (MDA) levels inducible nitric oxide synthase (iNOS) expression remarkable increase glutathione (GSH). Histological improvements further support potential natural protectant. Further pre-clinical clinical investigations will be required deliver drug promising protection

Language: Английский

Citations

Hepatoprotective Effect of a Kalanchoe pinnata –Based Beverage Against Carbon Tetrachloride– and Gentamicin-Induced Hepatotoxicity in Wistar Rats DOI

Kanza Saeed, Muhammad Farhan Jahangir Chughtai, Samreen Ahsan

et al.

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 12, 2025

Objective Chronic liver diseases are accountable for approximately 2 million deaths annually. The current study aimed to test the putative prophylactic role of Kalanchoe pinnata against hepatic stress.

Language: Английский

Citations

Potensi hepatoprotektif ekstrak daun Euphorbia heterophylla L. dalam menurunkan kadar bilirubin pada tikus Wistar yang diinduksi INH dan rifampisin DOI

Khamdiyah Indah Kurniasih, Fauziah Fauziah,

Uki Septi Ratna

et al.

Journal of Pharmaceutical And Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 412 - 419

Published: March 2, 2025

Hepatitis adalah gangguan kerusakan hati yang ditandai dengan peradangan akibat berbagai faktor, salah satunya penggunaan obat. Kerusakan obat, atau drug-induced liver injury (DILI), memiliki prevalensi relatif tinggi. Isoniazid (INH) dan Rifampisin merupakan kombinasi obat berisiko menyebabkan DILI memicu hati. Salah satu parameter untuk menilai pengukuran kadar bilirubin serum total. Tanaman katemas (Euphorbia heterophylla L.) diketahui mengandung flavonoid, tanin, saponin sifat antioksidan kuat. Tingginya insiden mendorong perlunya eksplorasi terapi alternatif dalam mengatasi Katemas tanaman liar tumbuh melimpah, tetapi masih kurang dimanfaatkan. Penelitian ini bertujuan mengevaluasi aktivitas hepatoprotektif ekstrak daun katemas. Metode digunakan penelitian maserasi memperoleh pelarut etanol 96%. Pengujian dilakukan pada lima kelompok tikus total di semua kelompok. Semua diinduksi menggunakan INH RMP. Hasil menunjukkan bahwa Kelompok III IV, variasi dosis, hepatoprotektif. V, menerima dosis tertinggi sebesar 200 mg/kg BB, penurunan paling signifikan rata-rata terbesar (-0,226) standar deviasi kecil (±0,043).

Citations

Mitigation of benzo(a)pyrene-induced hepatotoxicity and oxidative damage in Nile tilapia (Oreochromis niloticus) using N-acetylcysteine-loaded starch nanoparticles in porous alginate beads through the CYP1A/Nrf2/HO-1 pathway DOI

Mohamed Abomosallam, Ahmed Ateya,

Amany M. Shosha

et al.

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(3)

Published: March 4, 2025

Language: Английский

Citations

Bioinformatics Identification of Shared Signaling Pathways and Core Targets Linking Benzo[a]pyrene Exposure to HCC Progression DOI

Yongle Li, Rong‐Rong He, Meng Tang

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154129 - 154129

Published: March 1, 2025

Language: Английский

Citations

Prospective Hepatoprotective Actions of Novel Nano-formulations of Sildenafil and Neem Extract in Counteracting Oral Carbon Tetrachloride-induced Liver Injury in Rats DOI

Mahmoud S. Sabra,

Essmat A. H. Allam,

Madeha Darwish

et al.

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)

Published: April 1, 2025

Language: Английский

Citations

Mechanism of Action of Dihydroquercetin in the Prevention and Therapy of Experimental Liver Injury DOI

Hewei Wei,

Ting Zhao, Xinglong Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3537 - 3537

Published: July 27, 2024

Liver disease is a global health problem that affects the well-being of tens thousands people. Dihydroquercetin (DHQ) flavonoid compound derived from various plants. Furthermore, DHQ has shown excellent activity in prevention and treatment liver injury, such as inhibition hepatocellular carcinoma cell proliferation after administration, normalization oxidative indices (like SOD, GSH) this tissue, down-regulation pro-inflammatory molecules (such IL-6 TNF-α). also exerts its therapeutic effects by affecting molecular pathways NF-κB Nrf2. This paper discusses latest research progress diseases (including viral drug alcoholic non-alcoholic fatty immune injury). It explores how to optimize application improve effectiveness treating diseases, which valuable for preparing potential drugs human conjunction with DHQ.

Language: Английский

Citations

Flavonoids from Rhododendron nivale Hook. f ameliorate alcohol-associated liver disease via activating the PPARα signaling pathway DOI

Xiao Guo, Chen Liu, Zhen Dong

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156215 - 156215

Published: Nov. 8, 2024

Language: Английский

Citations