Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 520 - 520
Published: April 9, 2024
Silymarin,
derived
from
Silybum
marianum,
has
been
used
in
traditional
medicine
for
various
ailments.
In
this
study,
the
cardioprotective
and
hepatoprotective
effects
of
silymarin
against
paracetamol-induced
oxidative
stress
were
examined
28
male
Swiss
Webster
mice,
divided
into
four
groups
treated
7
days
(via
oral
route)
with
(a)
saline
1
mL/kg
(control
group),
(b)
+
single
dose
paracetamol
110
mg/kg
on
7th
day;
(c)
50
mg/kg;
(d)
day.
vitro
vivo
antioxidant
activity
together
liver
enzyme
evaluated.
Histopathological
immunohistochemical
assessment
was
performed.
Silymarin
mitigated
injury
by
reducing
markers
such
as
lipid
peroxidation
restoring
activity.
treatment
resulted
a
significant
decrease
levels.
Reduced
necrosis
inflammatory
infiltrate
tissues
silymarin-treated
detected
well.
Immunohistochemical
analysis
demonstrated
reduced
expression
(COX2,
iNOS)
marker
(SOD2)
groups.
Similar
trends
observed
cardiac
tissue.
These
results
suggest
that
exerts
potent
stress,
making
it
promising
therapeutic
agent
heart
diseases
associated
damage.
Language: Английский
From Vine to Wine: Coloured Phenolics as Fingerprints
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(4), P. 1755 - 1755
Published: Feb. 9, 2025
Anthocyanins
are
important
bioactive
compounds
crucial
for
the
sensory
characteristics
of
red
wines.
Anthocyanin
profiles
205
monovarietal
wines
from
Canary
Islands
were
investigated.
Eleven
anthocyanins
identified
and
determined
using
HPLC-DAD.
concentrations
produced
in
fell
within
usual
range
observed
other
regions.
Red
elaborated
with
international
grape
cultivars
presented,
general,
higher
mean
than
those
autochthonous
cultivars.
The
influence
cultivar,
production
island,
denomination
origin,
wine
aging
on
anthocyanin
concentration
was
studied,
leading
to
deduction
that
parameter
highest
influence.
A
high
number
significant
correlations
between
found
out
supporting
a
common
organic
synthetic
way
these
coloured
phenolics.
Application
multivariate
analysis
techniques,
such
as
principal
component
discriminant
analysis,
tended
classify
samples
according
geographical
areas,
aging.
This
study
could
contribute
quality
control
verification
industry,
which
is
an
interesting
tool
prevention
fraud
increasing
consumer
confidence.
Language: Английский
HPLC/MALDI-TOF-MS characterization and nutraceutical potential of Seriphedium quettense extracts: A polarity directed solvent extraction and antioxidant kinetics
M. Tahir Shah,
No information about this author
Zheng Linyan,
No information about this author
Muhammad Nasar
No information about this author
et al.
Journal of Molecular Liquids,
Journal Year:
2025,
Volume and Issue:
unknown, P. 127349 - 127349
Published: March 1, 2025
Language: Английский
An untargeted metabolomics approach applied to the study of the bioavailability and metabolism of three different bioactive plant extracts in human blood samples
María del Carmen Villegas-Aguilar,
No information about this author
María de la Luz Cádiz Gurrea,
No information about this author
María Herranz-López
No information about this author
et al.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(18), P. 9176 - 9190
Published: Jan. 1, 2024
Advances
in
the
understanding
of
bioavailability
and
metabolism
bioactive
compounds
have
been
achieved
primarily
through
targeted
or
semi-targeted
metabolomics
approaches
using
hypothesis
potential
metabolized
compounds.
The
recent
development
untargeted
can
present
great
advantages
this
field,
such
as
discovery
new
to
study
from
multiple
matrices
simultaneously.
Thus,
proposes
use
an
strategy
based
on
HPLC-ESI-QTOF-MS
for
different
vegetal
sources.
Specifically,
has
applied
plasma
samples
collected
acute
human
intervention
three
(Hibiscus
sabdariffa,
Silybum
marianum
Theobroma
cacao).
This
approach
allowed
selection
those
significant
variables
associated
with
exogenous
metabolites
derived
consumption
their
subsequent
identification.
As
a
result,
14,
25
3
supplement
intake
were
significantly
detected
volunteers
who
ingested
H.
sabdariffa
(HS),
S.
(SM)
T.
cacao
(TC)
extracts.
Furthermore,
Tmax
values
computed
each
compound.
results
highlight
rapid
comprehensive
analysis
when
working
wide
range
plant
sources
biological
samples.
Language: Английский
Targeted breast cancer therapy using novel nanovesicle formulations of Olea europaea extract
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
180, P. 117583 - 117583
Published: Oct. 17, 2024
Language: Английский
The Application of Untargeted Metabolomic Approaches for the Search of Common Bioavailable Metabolites in Human Plasma Samples from Lippia citriodora and Olea europaea Extracts
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
and
Language: Английский