Correlation between atherogenic index of plasma and cardiovascular disease risk across Cardiovascular–kidney–metabolic syndrome stages 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

The Cardiovascular-kidney-metabolic (CKM) syndrome, a concept recently proposed by the American Heart Association (AHA), highlights intricate connection between metabolic, renal, and cardiovascular illnesses. Furthermore, Atherogenic Index of Plasma (AIP), useful biomarker for evaluating risk Cardiovascular Diseases (CVDs), has been associated with Adverse Events (ACEs). Nonetheless, its precise function in populations CKM syndrome Stages 0-3 remains unknown. This prospective study analyzed data 7,708 eligible participants (aged ≥ 45 years) from Chinese Longitudinal Research Ageing (CHARLS), particularly 2011-2012 baseline survey (Wave 1). primary exposure variable was AIP-a natural logarithm ratio Triglycerides (TGs) to High-Density Lipoprotein Cholesterol (HDL-C). On other hand, endpoint CVD incidence, which determined based on self-reported past diagnoses. relationship AIP population stages examined using Cox proportional model. Subgroup mediation analyses were performed further elucidate interactions among these factors. involved [Mean age = 58.00 years; Interquartile Range (IQR) 52.00-65.00 years]. developing increased significantly higher levels. Specifically, each unit increase 1.31 (95% CI 1.11-1.55), while Hazard Ratio (HR) group highest levels compared lowest 1.22 1.08-1.39). Mediation analysis revealed that metabolic accounted 12.3% association (p 0.024), highlighting significance assessment. Herein, correlated positively individuals 0-3, as key mediating factor. These findings suggest could be valuable not only assessment but also clinical screening.

Language: Английский

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Animal Models for Studying Developmental Origins of Cardiovascular–Kidney–Metabolic Syndrome

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 452 - 452

Published: Feb. 12, 2025

Cardiovascular-kidney-metabolic syndrome (CKMS) has become a significant global health challenge. Since CKMS often originates early in life, as outlined by the developmental origins of and disease (DOHaD) concept, prevention is more effective strategy than treatment. Various animal models, classified environmental exposures or mechanisms, are used to explore CKMS. However, no single model can fully replicate all aspects its clinical stages, limiting advancement preventive therapeutic strategies. This review aims assist researchers comparing strengths limitations common models programming studies highlighting key considerations for selecting suitable models.

Language: Английский

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Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 995 - 995

Published: March 12, 2025

The benefits of breastfeeding for both mother and infant are generally recognized; however, the connections between breast milk, lactation, long-term offspring health disease remain incompletely understood. Cardiovascular–kidney–metabolic syndrome (CKMS) has become a major global public challenge. Insufficient milk supply, combined with various early-life environmental factors, markedly increases future risk CKMS, as highlighted by developmental origins (DOHaD) concept. Given its richness in nutrients bioactive components essential health, this review focuses on reprogramming strategies involving to improve offspring’s cardiovascular, kidney, metabolic health. It also highlights recent experimental advances understanding mechanisms driving CKMS programming. Cumulatively, evidence suggests that lactational impairment heightens development. In contrast, early interventions during lactation period focused animal models leverage response cues show potential improving outcomes—an area warranting further investigation clinical translation.

Language: Английский

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Oxidative Stress in Maternal and Offspring Kidney Disease and Hypertension: A Life-Course Perspective

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 387 - 387

Published: March 26, 2025

Kidney disease and hypertension are interconnected, prevalent conditions that affect both pregnant women children. Oxidative stress occurs when reactive oxygen species or nitrogen exceed the capacity of antioxidant systems. It plays a critical role in kidney development, resulting programming increased risks for across life course. Animal models have significantly advanced our understanding oxidative stress-related programming, molecular mechanisms involved, early-life interventions to prevent disease. This review critically examines influence perinatal on highlighting its long-term effects outcomes susceptibility hypertension. also explores potential antioxidant-based preventing Furthermore, addresses existing gap between insights gained from animal their translation into clinical practices, emphasizing challenges opportunities future research this area.

Language: Английский

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Melatonin's paradox: From therapeutic benefits to toxicity warnings

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111556 - 111556

Published: May 1, 2025

Language: Английский

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Kidney Programming and Hypertension: Linking Prenatal Development to Adulthood

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13610 - 13610

Published: Dec. 19, 2024

The complex relationship between kidney disease and hypertension represents a critical area of research, yet less attention has been devoted to exploring how this connection develops early in life. Various environmental factors during pregnancy lactation can significantly impact development, potentially leading programming that results alterations both structure function. This contribute adverse long-term outcomes, such as hypertension. In the context programming, molecular pathways involved are intricate include epigenetic modifications, oxidative stress, impaired nitric oxide pathway, inappropriate renin–angiotensin system (RAS) activation, disrupted nutrient sensing, gut microbiota dysbiosis, altered sodium transport. review examines each these mechanisms highlights reprogramming interventions proposed preclinical studies prevent related programming. Given strategies differ considerably from conventional treatments for disease, it is essential shift focus toward understanding processes its role development programmed

Language: Английский

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The Effects of Colchicum Dispert and Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Skeletal Muscle Injury in a Rat Aortic Ischemia–Reperfusion Model

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(8), P. 251 - 251

Published: Aug. 16, 2024

Background: Abdominal aortic aneurysms and peripheral artery disease pose significant health risks, ranking third after heart attacks cerebral strokes. Surgical interventions often involve temporary clamping, leading to ischemia–reperfusion injury tissue damage. Colchicine mesenchymal stem cells have shown promise, individually, in mitigating injury, but their combined effects remain understudied. Methods: This study utilized 42 male Wistar rats, divided into six groups: Control, Sham, Ischemia–Reperfusion, Colchicine, Mesenchymal cell, Mix (colchicine cell). The model involved clamping the abdominal aorta for 60 min, followed by 120 min of reperfusion. cell treatments were administered as pre- post-ischemia interventions, respectively. cultured, characterized flow cytometry, verified specific surface antigens. Blood samples analyzed oxidative stress markers, nitric oxide metabolites, apoptosis using TUNEL. Results: There differences between groups terms serum total antioxidant capacity (p < 0.001) inflammation markers (ischemia-modified albumin, p = 0.020). therapy group (Mix) exhibited lowest levels. Arginine levels also showed variation 0.028), confirming model. In muscle tissues, 0.022), symmetric dimethylarginine, citrulline 0.05) indicated metabolism. Apoptosis was notably high anticipated. It appeared be reduced colchicine, cells, combination, with most decrease observed 0.001). Conclusions: highlights potential colchicine reduce damage caused injury. Further research is needed understand underlying mechanisms confirm clinical significance this approach treating extremity injuries.

Language: Английский

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TRATAMENTO FARMACOLÓGICO DA INSÔNIA NA GESTAÇÃO

Revista Contemporânea, Journal Year: 2024, Volume and Issue: 4(11), P. e6699 - e6699

Published: Nov. 25, 2024

Introdução: Em virtude das graves repercussões da insônia sobre a saúde do binômio materno-fetal, esforços vêm sendo despendidos no sentido de encontrar alternativas terapêuticas eficientes e seguras. Objetivos: vista disso, objetivou-se reunir as evidências disponíveis acerca dos fármacos comumente prescritos às gestantes para o tratamento em relação aos efeitos potencialmente deletérios tendo que impacto negativo distúrbio não tratado deve ser levado consideração. Metodologia: Trata-se uma revisão sistemática literatura realizada por meio buscas artigos indexados nas bases dados MEDLINE, LILACS IBECS. Resultados: Ao total foram selecionados 19 estudos cujos resultados evidenciaram opções farmacológicas na gestação incluem benzodiazepínicos medicamentos relacionados benzodiazepínicos, como Z, antipsicóticos, antidepressivos sedativos melatonina. A os evidencia melhora sono, mas existem adequados bem controlados humanos segurança clínica, riscos à materno-fetal. Sugere-se benefícios potenciais podem justificar uso medicamento mulheres grávidas, sobretudo nos casos quando há terapêuticas. Conclusão: Por se tratar um grande desafio prática diretrizes internacionais estabelecem abordagem compartilhada tomada decisão, envolvendo gestante seus familiares, prescrição terapia farmacológica durante gravidez.

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