Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis DOI Creative Commons

Parisa Faraji,

Elham Parandavar,

Hartmut Kühn

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Nov. 8, 2024

Alzheimer's disease (AD) is the most common human neurodegenerative disorder worldwide. Owing to its chronic nature, our limited understanding of pathophysiological mechanisms, and because lack effective anti-AD drugs, AD represents a significant socio-economic challenge for all industrialized countries. Neuronal cell death key factor in pathogenesis recent studies have suggested that neuronal ferroptosis may play major patho-physiological role. Since involves free radical-mediated lipid peroxidation, we hypothesized enteral administration radical scavenger butylated hydroxytoluene (BHT) might slow down or even prevent development AD-related symptoms an vivo animal model.

Language: Английский

Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease DOI Creative Commons

Parisa Faraji,

Hartmut Kühn, Shahin Ahmadian

et al.

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(3)

Published: July 3, 2024

Abstract Alzheimer’s disease (AD) is the most prevalent neurodegenerative worldwide and has a great socio-economic impact. Modified oxidative lipid metabolism dysregulated iron homeostasis have been implicated in pathogenesis of this disorder, but detailed pathophysiological mechanisms still remain unclear. Apolipoprotein E (APOE) lipid-binding protein that occurs large quantities human blood plasma, polymorphism APOE gene locus identified as risk factors for AD. The genome involves three major alleles ( APOE2 , APOE3 APOE4 ), which encode subtly distinct apolipoprotein isoforms (APOE2, APOE3, APOE4). canonic function these apolipoproteins transport brain, allele carriers much higher In fact, about 60% clinically diagnosed AD patients carry at least one their genomes. Although key processes AD, such extracellular beta-amyloid (Aβ) aggregation, mitochondrial dysfunction, neuroinflammation, formation neurofibrillary tangles, modified metabolism, ferroptotic cell death, underlying molecular are not well understood. As all mammalian cells, plays crucial role neuronal functions dysregulation also Imbalances impairment hydroperoxy lipid-reducing capacity induce cellular dysfunction leading to ferroptosis. review, we summarize current knowledge on -related potential ferroptosis Pharmacological interference with might offer innovative strategies therapeutic interventions.

Language: Английский

Citations

6
The role of ferroptosis in neurodegenerative diseases DOI Creative Commons
Yifan Fei,

Yunjie Ding

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 15, 2024

Ferroptosis represents an iron − and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence strongly suggests the involvement ferroptosis in various neurodegenerative diseases (NDs), particularly Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), multiple sclerosis (MS), amyotrophic lateral (ALS), among others. The treatment poses both opportunities challenges context ND. This review provides a comprehensive overview characteristic features, induction inhibition ferroptosis, highlighting inhibitor underlying mechanisms responsible for its occurrence. Moreover, explores how these contribute to pathogenesis progression major disorders. Additionally, it presents novel insights into role ND summarizes recent advancements development therapeutic approaches targeting ferroptosis. These hold potential guide future strategies aimed at effectively managing debilitating medical conditions.

Language: Английский

Citations

5
Controlled release of vitamin A palmitate from crosslinked cyclodextrin organic framework for dry eye disease therapy DOI
Xinyue Ye,

Falan Li,

Mingwei Li

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124279 - 124279

Published: May 26, 2024

Language: Английский

Citations

4
New curcumin derivative induces ferroptosis in MCF-7 cells through activating SLC7A11/GPX4 axis DOI
Zhiwen Wu, Guoqiang Zhang,

Yifan Shang

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118078 - 118078

Published: Jan. 1, 2025

Language: Английский

Citations

0
Investigating mechanisms of apoptosis of humic acid on Leishmania tropica: An in vitro and in silico approach. DOI Creative Commons
Mahsa Faramarzpour, Alireza Keyhani, Ehsan Salarkia

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43017 - e43017

Published: March 1, 2025

Highlights•Humic acid (HA) demonstrated significant potential to trigger programmed cell death in Leishmania tropica-infected macrophages. This effect was observed through the probable modulation of both intrinsic and extrinsic apoptotic pathways.•HA combined with meglumine antimoniate (MA), revealed enhanced anti-leishmanial activity. The combination treatment exhibited a nearly additive effect, leading greater efficacy diminishing viability L. tropica parasites, particularly amastigote form, compared either alone.•Molecular docking assay indicated that HA binds beneficially key proteins, Bax Bcl2.•The study found also boosts antioxidative activities intra-macrophage amastigotes. suggests may eliminate oxidative stress, which is often elevated during leishmaniasis, thereby improving overall therapeutic profile against infection.•Generally, findings indicate humic could serve as promising agent for treating especially when used conventional treatments like antimoniate. emphasizes need further exploration HA's mechanisms its application animal studies.AbstractLeishmaniasis, parasitic neglected tropical disease, contributes remarkably global morbidity mortality. Current are facing multiple limitations, including side effects, drug resistance, high costs. Consequently, there pressing develop efficacious, widely accessible, lower-toxic compounds. Humic has previously shown potential, targeting apoptosis-related pathways cancerous infected cells. research structured investigate activity alone (MA) on infection. We employed molecular predict functional residues structural pockets Bcl2 proteins. Then, we conducted vitro assessments, protein expression analysis, immunocytochemistry profiles antioxidant mediators treated human Molecular binding interactions between Furthermore, more MA by inducing action, specifically apoptosis macrophages amastigotes modulating level proteins involved internal external assays. Notably, our results displayed can promote amastogites tropica. Thus, these vivo ex studies, antimonials.Graphical abstract

Language: Английский

Citations

0
Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases DOI Creative Commons

Taiwei Jiao,

Y. Chen,

Haiyan Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107370 - 107370

Published: Aug. 23, 2024

Ferroptosis, an emerging paradigm of programmed cellular necrosis posited in recent years, manifests across a spectrum maladies with profound implications for human well-being. Numerous investigations substantiate that modulating ferroptosis, whether through inhibition or augmentation, plays pivotal role the etiology and control numerous age-related afflictions, encompassing neurological, circulatory, respiratory, other disorders. This paper not only summarizes regulatory mechanisms but also discusses impact ferroptosis on biological processes aging its diseases. Furthermore, it scrutinizes therapeutic strides addressing aging-related conditions modulation ferroptosis. The consolidates existing knowledge potential applications ferroptosis-related pharmacotherapies envisages translational prospects ferroptosis-targeted interventions clinical paradigms.

Language: Английский

Citations

3
Ferroptosis in Ischemic Stroke and Related Traditional Chinese Medicines DOI Creative Commons

Runchen Ma,

Xiaohui Sun, Zhaofeng Liu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4359 - 4359

Published: Sept. 13, 2024

Stroke is a severe neurological disorder resulting from the rupture or blockage of blood vessels, leading to significant mortality and disability worldwide. Among different types stroke, ischemic stroke (IS) most prevalent, accounting for 70-80% cases. Cell death following IS occurs through various mechanisms, including apoptosis, necrosis, ferroptosis. Ferroptosis, recently identified form regulated cell characterized by iron overload lipid peroxidation, was first described Dixon in 2012. Currently, only approved pharmacological treatment recombinant tissue plasminogen activator (rt-PA), which limited narrow therapeutic window often results suboptimal outcomes. Recent research has several traditional Chinese medicines (TCMs) that can inhibit ferroptosis, thereby mitigating damage caused IS. This review provides an overview role ferroptosis IS, potential certain TCMs contribute treatment.

Language: Английский

Citations

1
The Potential Role of Non-coding RNAs in Regulating Ferroptosis in Cancer: Mechanisms and Application Prospects DOI

Ming-Yuan Cao,

Zhendong Zhang,

Xin-Rui Hou

et al.

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(16), P. 1182 - 1196

Published: July 18, 2024

: Cancer is the second leading cause of death globally. Despite some successes, conventional cancer treatments are insufficient to address growing problem drug resistance in tumors and achieve efficient treatment outcomes. Therefore, there an urgent need explore new therapeutic options. Ferroptosis, a type iron- reactive oxygen species-dependent regulated cell death, has been closely associated with development progression. Non-coding RNAs (ncRNAs) class that do not code for proteins, studies have demonstrated their involvement regulation ferroptosis cancer. This review aims molecular regulatory mechanisms ncRNAs involved emphasize feasibility as novel strategies We conducted systematic extensive literature using PubMed, Google Scholar, Web Science, various other sources identify relevant on ferroptosis, ncRNAs, A deeper understanding could facilitate strategies.

Language: Английский

Citations

0
Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis DOI Creative Commons

Parisa Faraji,

Elham Parandavar,

Hartmut Kühn

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Nov. 8, 2024

Alzheimer's disease (AD) is the most common human neurodegenerative disorder worldwide. Owing to its chronic nature, our limited understanding of pathophysiological mechanisms, and because lack effective anti-AD drugs, AD represents a significant socio-economic challenge for all industrialized countries. Neuronal cell death key factor in pathogenesis recent studies have suggested that neuronal ferroptosis may play major patho-physiological role. Since involves free radical-mediated lipid peroxidation, we hypothesized enteral administration radical scavenger butylated hydroxytoluene (BHT) might slow down or even prevent development AD-related symptoms an vivo animal model.

Language: Английский

Citations

0