Inside the genome: understanding genetic influences on oxidative stress

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: June 25, 2024

Genetics is a key factor that governs the susceptibility to oxidative stress. In body, burden regulated by balance between prooxidant genes orchestrate processes produce oxidant species, while antioxidant aid those involved in scavenging these species. Together, two components maintaining body. Genetic variations can influence expression and activity of encoded proteins which then affect their efficiency regulating redox processes, thereby increasing risk This review studies single nucleotide polymorphisms (SNPs) bear relevance stress exploring genes, such as XDH, CYBA, CYP1A1, PTGS2, NOS, MAO including SOD, CAT, GPX, GSS, GLUL, GSR, GSTM1, GSTM5, GSTP1, TXN HMOX1. Early identification individuals at increased possible from assessment sequence genes. Integrating genetic insights into management measures pave way for personalized medicine tailors’ healthcare approaches individual profiles. Effective along with routine quantification biological markers improve monitor treatment strategies, enhancing mitigation maintain cellular health promote longevity.

Language: Английский

Causal Effects of Oxidative Stress on Diabetes Mellitus and Microvascular Complications: Insights Integrating Genome-Wide Mendelian Randomization, DNA Methylation, and Proteome

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 903 - 903

Published: July 26, 2024

Oxidative stress (OS) is involved in the development of diabetes, but genetic mechanisms are not completely understood. We integrated multi-omics data order to explore relations between OS-related genes, diabetes mellitus, and microvascular complications using Mendelian randomization colocalization analysis.

Language: Английский