Study of Subacute Toxicity in Wistar Rats Challenged with Phyllanthus amarus Schum and Thonn DOI Open Access

Kpomah Enyohwo Dennis,

K. Bridget,

Okonkwo Chisom Stanislaus

et al.

Journal of Complementary and Alternative Medical Research, Journal Year: 2024, Volume and Issue: 25(8), P. 36 - 46

Published: Aug. 5, 2024

Phyllanthus amarus, a widely used plant in complementary and alternative medicine practice Southern Nigeria, is treating managing numerous metabolic disorders, neurodegenerative diseases. This study designed to assess the subacute toxicity of P. amarus Wistar rats using body relative organ weight, renal function, in-vivo antioxidant status histology indices as baseline. The twenty adult male weighing 120.00 ± 6.18 g were apportioned into four groups with five per group. Group A (Control) received 1.0 mL distilled water, group B 1000 mg/kg C 1500 D 2000 weight crude ethanol extract. extract from was administered orally once daily at 8:30 am an oral cannula attached 2 syringe. Subacute evaluated after 14 days. findings showed no visible noticeable overt signs throughout experimental period, non-significant adverse change function histopathology treated control groups. However, significantly improved while reducing level malondialdehyde, biological indicator oxidative stress living system.

Language: Английский

Ginsenoside Compound K Alleviates Brain Aging by Inhibiting Ferroptosis through Modulation of the ASK1-MKK7-JNK Signaling Pathway DOI
Xiaojun Yan, Xue Bai,

Guanghui Sun

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156239 - 156239

Published: Nov. 10, 2024

Language: Английский

Citations

1
Study of Subacute Toxicity in Wistar Rats Challenged with Phyllanthus amarus Schum and Thonn DOI Open Access

Kpomah Enyohwo Dennis,

K. Bridget,

Okonkwo Chisom Stanislaus

et al.

Journal of Complementary and Alternative Medical Research, Journal Year: 2024, Volume and Issue: 25(8), P. 36 - 46

Published: Aug. 5, 2024

Phyllanthus amarus, a widely used plant in complementary and alternative medicine practice Southern Nigeria, is treating managing numerous metabolic disorders, neurodegenerative diseases. This study designed to assess the subacute toxicity of P. amarus Wistar rats using body relative organ weight, renal function, in-vivo antioxidant status histology indices as baseline. The twenty adult male weighing 120.00 ± 6.18 g were apportioned into four groups with five per group. Group A (Control) received 1.0 mL distilled water, group B 1000 mg/kg C 1500 D 2000 weight crude ethanol extract. extract from was administered orally once daily at 8:30 am an oral cannula attached 2 syringe. Subacute evaluated after 14 days. findings showed no visible noticeable overt signs throughout experimental period, non-significant adverse change function histopathology treated control groups. However, significantly improved while reducing level malondialdehyde, biological indicator oxidative stress living system.

Language: Английский

Citations

0