An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical

Language: Английский

Isolation of a novel marine Aspergillus fumigatus strain AFK11 and inhibition of inflammatory mediators

Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(2)

Published: May 5, 2025

Language: Английский