Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 114 - 114

Published: Jan. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Language: Английский

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Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 653 - 653

Published: Feb. 1, 2025

Gamma-tocopherol (γ-tocopherol), a major isoform of vitamin E, exhibits potent antioxidant, anti-inflammatory, and anticancer properties, making it promising therapeutic candidate for treating oxidative stress-related diseases. Unlike other tocopherol isoforms, γ-tocopherol effectively neutralizes reactive oxygen species (ROS) nitrogen (RNS), providing robust cellular protection against damage lipid peroxidation. Its anti-inflammatory effects are mediated through the modulation pathways involving cyclooxygenase-2 (COX-2) tumor necrosis factor-alpha (TNF-α), reducing chronic inflammation its associated risks. In cancer therapy, demonstrates multifaceted activity, including inhibition growth, induction apoptosis, suppression angiogenesis, with significant efficacy observed in cancers such as prostate, lung, colon. Preclinical clinical studies support mitigating stress, inflammation, progression, excellent tolerance at physiological levels. However, high doses necessitate careful evaluation to minimize adverse effects. This review consolidates current knowledge on γ-tocopherol’s biological activities implications, underscoring importance natural compound managing cancer. As perspective, advancements nanoformulation technology could enhance bioavailability, stability, targeted delivery, offering potential optimize application future.

Language: Английский

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Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A Narrative Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 597 - 597

Published: May 13, 2024

Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and body’s antioxidant defenses. It poses a significant threat to physiological function reproductive cells. Factors such as xenobiotics heat can worsen this stress, leading cellular damage apoptosis, ultimately decreasing efficiency. The nuclear factor erythroid 2–related 2 (Nrf2) signaling pathway plays crucial role in defending against oxidative protecting cells via enhancing responses. Dysregulation Nrf2 has been associated with infertility suboptimal performance mammals. Recent advancements therapeutic interventions have underscored critical mitigating restoring functional integrity In narrative review, we delineate harmful effects xenobiotic-induced on explain how provides protection these challenges. studies shown that activating using various bioactive compounds ameliorate distress apoptosis mammalian By comprehensively analyzing existing literature, propose key target for caused by exposure xenobiotic stress. Additionally, based synthesis findings, discuss potential therapies focused improve

Language: Английский

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Regulation of Oil Biosynthesis and Genetic Improvement in Plants: Advances and Prospects

Genes, Journal Year: 2024, Volume and Issue: 15(9), P. 1125 - 1125

Published: Aug. 26, 2024

Triglycerides are the main storage form of oil in plant seeds. Both fatty acids and triglycerides possess important functions process growth development. To improve seed content its acid composition, this paper analyzed research progress on regulation synthesis metabolism seeds summarized strategies for improvement oil: (a) regulate carbon distribution by inhibiting expression genes encoding key enzymes, allocating sources into protein pathway, enhancing leading pathway acids; (b) intervene lipid promoting biosynthesis improving level enzymes triacylglycerol (TAG) assembly process; (c) quality altering composition regulating gene desaturase, as well introducing an exogenous long chain polyunsaturated (d) transcription factors to increase content. In addition, article reviews involved acids, triacylglycerol, process. It also summarizes regulatory roles such

Language: Английский

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Unveiling the health benefits of argan oil: Bioactive molecules and phytochemical insights for food applications

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107542 - 107542

Published: March 1, 2025

Language: Английский

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Virtual Screening of Kelch-like ECH-Associated Protein 1−Nuclear Factor Erythroid 2-Related Factor 2 (Keap1−Nrf2) Inhibitors and In Vitro Validation

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1815 - 1815

Published: April 17, 2025

The transcription factor erythroid 2-related 2 (Nrf2) is a central regulator of cellular defense mechanisms against oxidative stress and inflammation. Keap1 (Kelch-like ECH-associated protein 1) regulates Nrf2 activity by ubiquitination-mediated cytoplasmic retention, thereby suppressing its nuclear translocation subsequent transcriptional activation genes encoding phase II detoxifying enzymes. Using structure-based virtual screening approach, we screened ~16,000 natural compounds to identify Keap1-Nrf2 PPI inhibitors. Nine were identified based on their high binding affinities favorable interactions with Keap1, primarily through non-covalent interactions. To validate the stability these inhibitors, molecular dynamics (MD) simulations performed, confirming robustness Keap1-inhibitor complexes over time. Subsequent in vitro assays human epithelial keratinocyte cells (HaCaT) revealed that six notably upregulated mRNA expression, regis tering increases from 23% 50% comparison control. Notably, chebulinic acid emerged as most potent compound, demonstrating greatest elevation expression. Penetration studies further showed acid, when encapsulated silk fibroin, achieved 0.14% penetration rate after 24 h though it could not penetrate into stratum corneum alone. This result highlighted potential use anti-aging skincare formulations. Collectively, our findings affirmed docking reliable effective approach for identification novel agents targeting pathway.

Language: Английский

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Argan Oil: A Natural Bioactive Lipid Modulating Oxidative Stress and Inflammation

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 515 - 515

Published: April 25, 2025

Nutrition is a key determinant in modulating disease risk, with numerous studies highlighting the role of antioxidants and lipids, particularly micronutrient fatty acid composition natural oils their bioactive metabolites. In this context, argan oil—a vegetable oil extracted from kernels Argania spinosa—has gained significant attention due to its well-balanced profile, rich oleic linoleic acids, high levels antioxidant compounds, including tocopherols, polyphenols, phytosterols, schottenol spinasterol. Thanks unique composition, exhibits protective properties against harmful biological processes, such as oxidative stress inflammation, both which play various diseases. Preclinical studies, vitro vivo, have demonstrated that reduces by preventing DNA damage, protein carbonylation, lipid peroxidation, while simultaneously increasing defenses. Furthermore, it modulates inflammatory responses decreasing pro-inflammatory biomarkers, anti-inflammatory markers, limiting immune cell infiltration across different tissues. These effects are thought be linked oil’s ability regulate signaling pathways, Nrf-2 NF-κB. Although direct evidence remains limited, suggest main components—fatty acid, γ-tocopherol, ferulic campesterol—can influence these either activating Nrf2 boost defenses or inhibiting NF-κB suppress inflammation. This review explores oil, drawing insights range scientific better understand therapeutic potential.

Language: Английский

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Antioxidant Effects of Cactus Seed Oil against Iron-Induced Oxidative Stress in Mouse Liver, Brain and Kidney

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4463 - 4463

Published: Sept. 20, 2024

In recent times, exploring the protective potential of medicinal plants has attracted increasing attention. To fight reactive oxygen species (ROS), which are key players in hepatic, cerebral and renal diseases, scientists have directed their efforts towards identifying novel compounds with antioxidant effects. Due to its unique composition, significant attention been given Cactus Seed Oil (CSO). Iron, as a metal, can be potent generator species, especially hydroxyl radicals, via Fenton Haber–Weiss reactions. Here, we employed ferrous sulfate (FeSO4) induce oxidative stress DNA damage mice. Then, used CSO Colza oil (CO) evaluated levels antioxidants (superoxide dismutase [SOD], glutathione peroxidase [GPx] [GSH]) well metabolite marker for lipid peroxidation (malondialdehyde [MDA]) relating balance liver, brain kidney. addition, measured hepatic tissue effects on it. Our study found that iron-dependent GPx activity decreases liver kidney tissues. Additionally, while iron decreased SOD it increased Interestingly, treatment resulted increase MDA levels. contrast, tissue, there was decrease under treatment. varying alleviating different tissues ameliorating after overload mouse model, adding compelling evidence CSO.

Language: Английский

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Ethnopharmacological Knowledge and Antioxidant Propensities of Argania spinosa L. from Morocco

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

This work aims to merge ethnopharmacological knowledge with biochemical analysis enrich our understanding of the significance argan tree ( Argania spinosa (L.) Skeels) and valorize its crucial role in province Essaouira (Morocco). First, a survey was conducted using semistructured interviews 325 informants from between February April 2023. The covered sociodemographic data information on uses, whether for therapeutic, cosmetic, or food purposes (i.e., applications, parts used, preparation, administration). Second, phenolic extracts were prepared various leaves, kernels, nut shells, press cake, oil) then assessed their antioxidant potential scientifically validate traditional uses. evaluation activity focused free radical scavenging reducing capacities, DPPH FRAP assays. Findings confirmed cultural local population, as well strong dependence products. Indeed, it noted that argan‐based products are widely favored cuisine, prevalence 83.4%; Amlou is most commonly consumed food. Therapeutic cosmetic applications accounted 48.6% 28.0%, respectively, predominantly treating skin subcutaneous issues (69.5%) diabetes (19.7%). Argan oil cited product often raw (97.5%), followed by almonds (22.8%). Cataplasm (26.1%) maceration (24.6%) preferred derivative preparation. External application (50.1%) primary administration method, oral consumption (38.1%) massage (27.7%). For vitro assays, could prove be promising source compounds, especially leaves (>4 times richer than other parts, 231.046 ± 5.090 mg GAE/g DW). tests demonstrated notable antiradical power, concentration‐dependent. Leaf‐derived exhibited highest (IC50 = 0.589 0.005 mg/ml) best capacity 0.420 mg/ml), although these potencies remained below standard used. study represents valuable documentation can serve preserve use while exploring phytochemical pharmacological properties.

Language: Английский

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Study of Pentacyclic Triterpenes from Lyophilised Aguaje: Anti-Inflammatory and Antioxidant Properties

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9615 - 9615

Published: Sept. 5, 2024

Mauritia flexuosa (M. flexuosa), commonly known as Aguaje or Moriche palm, is traditionally recognised in South America for its medicinal properties, particularly anti-inflammatory and antioxidant effects. However, the bioactive compounds responsible these effects have not been thoroughly investigated. This study aims to isolate characterise pentacyclic triterpenoid from M. evaluate their therapeutic potential. Using various chromatographic spectroscopic techniques including Nuclear Magnetic Resonance (NMR) Mass Spectrometry (MS), three were successfully isolated. Among them, compound 1 (3,11-dioxours-12-en-28-oic acid) exhibited notable bioactivity, significantly inhibiting activation of Factor kappa-light-chain-enhancer activated B cells (NF-κB) (IC50 = 7.39–8.11 μM) Nitric Oxide (NO) 4.75–6.59 μM), both which are key processes inflammation. Additionally, demonstrated potent properties by activating enzyme Superoxide Dismutase (SOD) (EC50 1.87 transcription factor erythroid 2-related 2 (Nrf2) 243–547.59 nM), thus showing potential combating oxidative stress. first flexuosa, suggesting that could be a promising candidate development safer more effective therapies inflammatory stress-related diseases.

Language: Английский

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