Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats DOI Open Access

Alaa Muqbil Alsirhani,

Amal S. Abu-Almakarem,

Maha Abdullah Alwaili

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12541 - 12541

Published: Nov. 22, 2024

Doxorubicin (DOX), an anticancer drug, is used to treat several types of tumors, but it has detrimental side effects that restrict its therapeutic efficacy. One the iron-dependent form ferroptosis, which characterized by elevated ROS production and iron overload.

Language: Английский

Silver nanoparticles induce liver inflammation through ferroptosis in zebrafish DOI
Yuansi Zheng, Jie Song, Qiuhui Qian

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142673 - 142673

Published: June 28, 2024

Language: Английский

Citations

7
Spermidine mitigates ferroptosis in free fatty acid-induced AML-12 cells through the ATF4/SLC7A11/GCLM/GPX4 pathway DOI
Jia Zhang, Tao Zhang, Yihang Chen

et al.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: 1869(8), P. 159560 - 159560

Published: Aug. 23, 2024

Language: Английский

Citations

5
Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications DOI Open Access

Shanjie Tu,

Yisheng Zou,

Meiqi Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117769 - 117769

Published: Dec. 16, 2024

Language: Английский

Citations

3
The role of ferroptosis-related non-coding RNA in liver fibrosis DOI Creative Commons
Guozhu Zhang, Kejia Wu, Xiaobo Jiang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 9, 2024

Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in progression of liver disease. This pathological is characterized excessive accumulation extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs function. To date, no specific antifibrotic drugs have been developed, advanced remains largely incurable. transplantation sole efficacious intervention for fibrosis; nevertheless, it constrained exorbitant costs risk postoperative immune rejection, underscoring imperative novel therapeutic strategies. Ferroptosis, an emergent form regulated cell death, has identified as pivotal regulatory mechanism development intricately linked with diseases. Recent investigations elucidated that diverse array non-coding RNAs (ncRNAs), including microRNAs, long RNAs, circular are involved ferroptosis pathway, thereby modulating various diseases, fibrosis. In recent years, roles ferroptosis-related ncRNAs attracted escalating scholarly attention. paper elucidates pathophysiology fibrosis, explores mechanisms underlying ferroptosis, involvement ncRNA-mediated pathways pathology aims propose strategies prevention

Language: Английский

Citations

1
Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats DOI Open Access

Alaa Muqbil Alsirhani,

Amal S. Abu-Almakarem,

Maha Abdullah Alwaili

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12541 - 12541

Published: Nov. 22, 2024

Doxorubicin (DOX), an anticancer drug, is used to treat several types of tumors, but it has detrimental side effects that restrict its therapeutic efficacy. One the iron-dependent form ferroptosis, which characterized by elevated ROS production and iron overload.

Language: Английский

Citations

0