Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 9, 2024

Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in progression of liver disease. This pathological is characterized excessive accumulation extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs function. To date, no specific antifibrotic drugs have been developed, advanced remains largely incurable. transplantation sole efficacious intervention for fibrosis; nevertheless, it constrained exorbitant costs risk postoperative immune rejection, underscoring imperative novel therapeutic strategies. Ferroptosis, an emergent form regulated cell death, has identified as pivotal regulatory mechanism development intricately linked with diseases. Recent investigations elucidated that diverse array non-coding RNAs (ncRNAs), including microRNAs, long RNAs, circular are involved ferroptosis pathway, thereby modulating various diseases, fibrosis. In recent years, roles ferroptosis-related ncRNAs attracted escalating scholarly attention. paper elucidates pathophysiology fibrosis, explores mechanisms underlying ferroptosis, involvement ncRNA-mediated pathways pathology aims propose strategies prevention

Language: Английский