Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes DOI Open Access
Nilüfer Yeşilırmak, Özge Sarıtaş, Büşra Kurt

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4052 - 4052

Published: July 11, 2024

Background/Objective: The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters rosacea patients across skin subtypes the disease healthy controls. Methods: This prospective included 90 with different (phymatous, erythematotelangiectatic papulopustular) ocular involvement 30 Plasma native thiol (NT), total (TT) disulfide levels controls were measured using an automated spectrophotometric method, disulfide/native ratio (DNTR), disulfide/total (DTTR) thiol/total (NTTR) calculated. Tear breakup time (TBUT), meiboscore, Schirmer, surface index (OSDI) rosacea-specific quality life scale (RosaQoL) clinically. Results: Disulfide, DNTR DTTR significantly higher, NT, TT NTTR lower in compared (p < 0.001). TBUT Schirmer lower, meiboscore OSDI higher 0.01). According subtypes, disulfide, subtype other 0.002). RosaQol 0.0083). Strong correlations found between Meiboscore all 0.005), while there strong only papulopustular 0.05). Conclusions: shifted towards disulfides, indicator oxidative stress rosacea, more pronounced subtype. impairment also prominent strongly associated DNTR.

Language: Английский

Vitamin C: Its Role in Cosmeceuticals DOI Open Access
Nupur Singh,

Angela N. Brown,

Max Oscherwitz

et al.

Dermatological Reviews, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 14, 2025

ABSTRACT Background Vitamin C is a well‐known product used in cosmeceuticals for its various topical application benefits ranging from antioxidative, antiaging, anti‐inflammatory, and anti‐pigmentary among others. The main problems encountered with vitamin products include the stability, penetrance into skin, tolerance of C's forms. Aims This paper aims to explore current literature on role cosmetic dermatology present review how have developed certain purposes their outcomes. Methods A search was conducted PubMed reviewing non‐cosmetic formulations utility dermatologic conditions. Research produced by journals then investigated highlight uses potential field. Results Numerous studies support varied claims regarding C, particularly as an antioxidant, anti‐pigmentary, anti‐inflammatory agent. integration other ingredients rapidly developing, E natural plant extracts several exfoliative acids growth factors. industry's next steps involve better stabilization improve synergistic mechanisms without lowering bioavailability, efficacy, or absorption. Conclusions has proven be powerful player dermatology, both stand‐alone element combination ingredients. showcases some most pertinent clinical that efficacy mitigating photoaging, oxidative stress, abnormal pigmentation, inflammation concerns, underscoring promise behind C.

Language: Английский

Citations

0

Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications DOI Creative Commons
Juan Salazar, Ángel Ortega, José L. Pérez

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 247 - 247

Published: Feb. 12, 2025

Although not frequently lethal, dermatological diseases represent a common cause of consultation worldwide. Due to the natural and non-invasive approach phytotherapy, research for novel alternatives, such as polyphenols, treat skin disorders is subject interest in modern medicine. Polyphenols, particular, have been considered because their anti-inflammatory, antitumoral, antimicrobial, antioxidant properties, low molecular weight, lipophilic nature that enables passage these compounds through barrier. This review discusses treatment acne vulgaris, fungal infections, dermatitis, alopecia, cancer, using polyphenols therapeutic prophylactic options. The specific molecules each disorder, mechanisms action, current clinical trials, proposed applications are also reviewed.

Language: Английский

Citations

0

The Effect of Chokeberry Juice and Fiber Consumption on the Concentration of Antioxidant Minerals in Serum DOI Creative Commons
Ewa Olechno, Małgorzata Elżbieta Zujko, Katarzyna Socha

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 516 - 516

Published: April 25, 2025

Aronia is a fruit that has become increasingly popular in recent years. Numerous health-promoting effects resulting from consumption have been indicated, including the possibility of using aronia as functional food prevention and support therapy for various ailments. For first time, we assessed impact 90-day nutritional intervention on level selected minerals serum women (n = 67) men 35). The 100 mL juice 60 days resulted significant increase levels copper, manganese, selenium. addition 10 g fiber further concentration these elements with antioxidant properties. An interesting observation zinc decreased, which may indicate operation compensatory mechanisms. above results regular bio-products beneficial effect microelements serum.

Language: Английский

Citations

0

The Antioxidant Power of a Diet May Improve the Quality of Life of Young Women with Acne Vulgaris DOI Open Access

Kinga Zujko-Kowalska,

Beata Jankowska‐Polańska, Małgorzata Elżbieta Zujko

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1270 - 1270

Published: April 25, 2024

Acne vulgaris (AV) significantly reduces the quality of life (QoL) young people, so it is important to look for factors that can improve their QoL. The aim this study was assess relationship between dietary antioxidants measured using new DAQI index and QoL standardized tests. included following elements: antioxidant vitamins, minerals, carotenoids, polyphenols, phytosterols, lignans, total capacity diet. involved 165 women with AV, mainly students. A self-report survey used collect basic data on sociodemographic status, anthropometric information, lifestyle. energy value diet content carotenoids activity in were estimated 3-day food diaries Diet 6.0 program. potential selenium calculated based consumption individual products available databases. results showed AV impaired. However, greater adherence an risk impact by approximately 30–32% depression 33%. may be as a indicator acne vulgaris.

Language: Английский

Citations

1

Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes DOI Open Access
Nilüfer Yeşilırmak, Özge Sarıtaş, Büşra Kurt

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4052 - 4052

Published: July 11, 2024

Background/Objective: The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters rosacea patients across skin subtypes the disease healthy controls. Methods: This prospective included 90 with different (phymatous, erythematotelangiectatic papulopustular) ocular involvement 30 Plasma native thiol (NT), total (TT) disulfide levels controls were measured using an automated spectrophotometric method, disulfide/native ratio (DNTR), disulfide/total (DTTR) thiol/total (NTTR) calculated. Tear breakup time (TBUT), meiboscore, Schirmer, surface index (OSDI) rosacea-specific quality life scale (RosaQoL) clinically. Results: Disulfide, DNTR DTTR significantly higher, NT, TT NTTR lower in compared (p < 0.001). TBUT Schirmer lower, meiboscore OSDI higher 0.01). According subtypes, disulfide, subtype other 0.002). RosaQol 0.0083). Strong correlations found between Meiboscore all 0.005), while there strong only papulopustular 0.05). Conclusions: shifted towards disulfides, indicator oxidative stress rosacea, more pronounced subtype. impairment also prominent strongly associated DNTR.

Language: Английский

Citations

0