Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice DOI Open Access

Gi Jung Kim,

So Young Lee, Seyeon Oh

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12522 - 12522

Published: Nov. 21, 2024

Steroids, which are often used to treat the inflammation associated with various skin diseases, have several negative side effects. As Ecklonia cava extract has anti-inflammatory effects in we evaluated efficacy of cava-derived extracellular vesicles (EVEs) decreasing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. We determined effect EVEs on TLR4/NF-κB/NLRP3 inflammasome human keratinocytes and mouse ear skin. TPA-treated showed an increased expression TLR4 its ligands HMGB1 S100A8. TPA also (1) NF-κB; (2) NLRP3 components NLRP3, ASC, caspase 1; (3) pyroptosis-related factors GSDMD-NT, IL-18, IL-1β. However, these molecules decreased after EVE treatment. Similar vitro results, skin, treatment their expression. The edema, redness, neutrophil infiltration, epidermal thickness, reduced symptoms In conclusion, TPA-induced inflammation, was a decrease inflammasome.

Language: Английский

Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery DOI Creative Commons
Arzu Zeynep Karabay, Jaleh Barar, Yalda Hekmatshoar

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 394 - 394

Published: March 10, 2025

Most eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred as extracellular vesicles (EVs), which offer several advantages producer/receiver cells. This review provides an overview EVs from plant sources with emphasis on their health-promoting possible use therapeutic agents. highlights essential biological effects plant-derived vesicles, including immune modulation, anticancer activities, protection against chemical toxicity pathogens, well anti-aging, anti-melanogenesis, anti-arthritic effects, along ongoing clinical studies. Evidence revealed that EVs’ contents exert beneficial properties through regulating important signaling pathways by transferring miRNAs other components. Taken all together, data proposed can be utilized nutritional compounds agents, such drug carriers. However, this emerging research area requires further in vitro/in vivo studies trials determine exact underlying mechanisms positive health treating various diseases.

Language: Английский

Citations

2
Single-step negative isolation and concentration of extracellular vesicles by graphene oxide composite hydrogels DOI
Huazhe Yang, Xinxin Liu, Kaiguang Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163066 - 163066

Published: April 1, 2025

Language: Английский

Citations

0
Cosmeceutical Applications of Phlorotannins from Brown Seaweeds DOI Creative Commons

D. M. N. M. Gunasekara,

Lei Wang, Kalahe Hewage Iresha Nadeeka Madushani Herath

et al.

Phycology, Journal Year: 2025, Volume and Issue: 5(2), P. 15 - 15

Published: April 27, 2025

Due to the adverse effects associated with synthetic cosmetic ingredients, global demand is increasingly shifting toward natural formulations that offer diverse benefits for enhancing skin health and overall beauty. Researchers around world are extensively exploring a variety of unique secondary metabolites cosmeceutical applications. Among potential candidates, phlorotannins derived from brown seaweeds have shown significant as an active ingredient in The notable properties include antioxidant, anti-aging, whitening, anti-wrinkling, anti-inflammatory, hair growth-promoting effects, making them valuable formulations. However, date, only limited number studies critically reviewed applications phlorotannins, most outdated. Thus, present review, primary attention given collected scientific data published after 2020 about bioactive seaweed related

Language: Английский

Citations

0
The Role of Phlorotannins to Treat Inflammatory Diseases DOI Creative Commons
Kalahe Hewage Iresha Nadeeka Madushani Herath, D. P. Nagahawatta, Lei Wang

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(3), P. 77 - 77

Published: May 4, 2025

Phlorotannins, bioactive compounds isolated from brown seaweeds, have garnered significant attention in recent years for their wide-ranging therapeutic properties, particularly anti-inflammatory effects. Recent studies identified phlorotannins as potent inhibitors of inflammatory pathways such NF-κB, MAPK, JAK/STAT3, and NLRP3. Specifically, derived seaweeds like Ecklonia cava, Ishige okamurae, Sargassum horneri been shown to inhibit the gene protein expression pro-inflammatory cytokines other mediators both vivo vitro conditions. Despite these promising findings, no commercial drugs seaweed yet developed treat diseases, reports clinical trials remain rare, even context functional food applications chronic To address this knowledge gap, authors reviewed peer-reviewed research articles published 2020 or later, focusing on potential phlorotannins. The insights provided review are expected be valuable industries groups others involved developing therapeutics.

Language: Английский

Citations

0
Proposing plant-derived extracellular vesicles as sustainable and safe bioactive nanocarriers for target-specific human skin transdermal therapeutics strategies DOI
Rizka Mulyani, Prakoso Adi, Bara Yudhistira

et al.

Sustainable materials and technologies, Journal Year: 2025, Volume and Issue: unknown, P. e01456 - e01456

Published: May 1, 2025

Language: Английский

Citations

0
Radiofrequency Treatment Attenuates Age-Related Changes in Dermal–Epidermal Junctions of Animal Skin DOI Open Access
Kyung-A Byun, Hyoung Moon Kim, Seyeon Oh

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5178 - 5178

Published: May 9, 2024

The dermal–epidermal junction (DEJ) is essential for maintaining skin structural integrity and regulating cell survival proliferation. Thus, DEJ rejuvenation key revitalization, particularly in age-related deterioration. Radiofrequency (RF) treatment, known its ability to enhance collagen fiber production through thermal mechanisms increase heat shock protein (HSP) expression, has emerged as a promising method rejuvenation. Additionally, RF activates Piezo1, an ion channel implicated macrophage polarization toward M2 phenotype enhanced TGF-β production. This study investigated the impact of treatment on HSP47 HSP90 stimulators expression. Furthermore, using vitro aged animal models, we assessed whether RF-induced Piezo1 activation subsequent could counter changes. H2O2-induced senescent keratinocytes upregulated expression HSP47, HSP90, TGF-β, proteins, including XVII. Similarly, macrophages increased CD206 (M2 marker) Conditioned media from RF-treated such nidogen IV, fibroblasts. In skin, markers associated with polarization, IL-10, TGF-β. Moreover, reduced lamina densa replication, disrupted lesions, promoted hemidesmosome formation, epidermal thickness. Overall, effectively mitigated changes by increasing HSP levels activating Piezo1.

Language: Английский

Citations

0
Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice DOI Open Access

Gi Jung Kim,

So Young Lee, Seyeon Oh

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12522 - 12522

Published: Nov. 21, 2024

Steroids, which are often used to treat the inflammation associated with various skin diseases, have several negative side effects. As Ecklonia cava extract has anti-inflammatory effects in we evaluated efficacy of cava-derived extracellular vesicles (EVEs) decreasing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. We determined effect EVEs on TLR4/NF-κB/NLRP3 inflammasome human keratinocytes and mouse ear skin. TPA-treated showed an increased expression TLR4 its ligands HMGB1 S100A8. TPA also (1) NF-κB; (2) NLRP3 components NLRP3, ASC, caspase 1; (3) pyroptosis-related factors GSDMD-NT, IL-18, IL-1β. However, these molecules decreased after EVE treatment. Similar vitro results, skin, treatment their expression. The edema, redness, neutrophil infiltration, epidermal thickness, reduced symptoms In conclusion, TPA-induced inflammation, was a decrease inflammasome.

Language: Английский

Citations

0